Calciphylaxis Quiz
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Redness of the skin
Affected area of skin has stinging or tingling
Skin has moles or spots of different colors
Wound
Red spots on skin
Pain or tingling in the affected areas of the skin
Black, blue, or brown spots on the skin or elsewhere
Not seeing your symptoms? No worries!
What is Calciphylaxis?
Calciphylaxis is a rare disorder, often seen in people with chronic end-stage kidney disease, where calcium deposits accumulate abnormally in blood vessels. This leads to blood clots, and the reduced blood flow can cause painful skin ulcers, which can be a potential source of severe infections that can result in death.
Typical Symptoms of Calciphylaxis
- Kidney failure on dialysis
- Black/blue/brown spots or moles, on the skin and lining of the mouth
- Affected area of skin has stinging or tingling
- Scab
- Dark spots on skin
- Arm pain
- Skin problems
- Skin problem of the legs, in the area between thigh and ankle
Diagnostic Questions for Calciphylaxis
Your doctor may ask these questions to check for this disease:
- Are you currently on dialysis?
- Are there black, blue, or brown spots on your skin? (Including moles)
- Do you feel any pain or tingling in the affected skin areas?
- Do you have a scab?
- Do you have darkened skin?
Treatment of Calciphylaxis
Though there is no cure for calciphylaxis, symptoms can be managed with wound care and pain control, as well as medications like sodium thiosulfate and other treatments to decrease calcium buildup.
Reviewed By:
Caroline M. Doan, DO (Internal Medicine)
Dr. Doan received a Bachelor of Science degree with honors from UCLA. Prior to obtaining her medical degree, she was involved in oncology clinical research at City of Hope, a National Cancer Institute-designated comprehensive cancer center in southern California. She attended medical school at Touro University California, and completed her residency in Internal Medicine at Oregon Health & Science University. She is certified by the American Board of Internal Medicine and holds an active medical license in several states. She currently works as a physician for Signify Health providing home-based health care.
Yukiko Ueda, MD (Dermatology)
Dr. Ueda graduated from the Niigata University School of Medicine and trained at the University of Tokyo Medical School. She is currently a clinical assistant professor at the Department of Dermatology, Jichi Medical University, and holds several posts in the dermatology departments at Kyoto Prefectural University of Medicine, Komagome Hospital, University of Tokyo, and the Medical Center of Japan Red Cross Society.
Content updated on Feb 19, 2025
Following the Medical Content Editorial Policy
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- Dark skin
- Moles or spots of different colors on skin or lining of the mouth
- Healing skin lesion
- Hyperpigmentation
- Black scabs
- There is darkened skin on the toe
- Scrape
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- Darker skin
- There is darkened skin on the chin
- There is darkened skin on the under the armpit
- Armpit skin is black
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See full list
Symptoms Related to Calciphylaxis
Diseases Related to Calciphylaxis
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Seethapathy H, Noureddine L (Year). Calciphylaxis: Approach to Diagnosis and Management. Advances in chronic kidney disease.
https://pubmed.ncbi.nlm.nih.gov/31831126/Gallo Marin B, Aghagoli G, Hu SL, Massoud CM, Robinson-Bostom L (Year). Calciphylaxis and Kidney Disease: A Review. American journal of kidney diseases : the official journal of the National Kidney Foundation.
https://pubmed.ncbi.nlm.nih.gov/35970430/Rick J, Strowd L, Pasieka HB, Saardi K, Micheletti R, Zhao M, Kroshinsky D, Shinohara MM, Ortega-Loayza AG (Year). Calciphylaxis: Part I. Diagnosis and pathology. Journal of the American Academy of Dermatology.
https://pubmed.ncbi.nlm.nih.gov/35114300/