Complex Regional Pain Syndrome Quiz

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Reviewed By:

Unnati Patel, MD, MSc

Unnati Patel, MD, MSc (Family Medicine)

Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.

Shohei Harase, MD

Shohei Harase, MD (Neurology)

Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.

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Content updated on Mar 31, 2024

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How Ubie Can Help You

With an easy 3-min questionnaire , Ubie's AI-powered system will generate a free report on possible causes.

Questions are customized to your situation and symptoms, including the following personal information:

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  • Age - adjusts our guidance based on any age-related health factors.

  • History - considers past illnesses, surgeries, family history, and lifestyle choices.

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People with similar symptoms also use Ubie's symptom checker to find possible causes

  • Aches all over my body

  • Thigh pain when resting

  • Pain in the upper arm

  • Sweating has decreased

  • Sharp stabbing pain in the thigh

  • Pain above the wrist

  • Fell on my hands

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What is Complex Regional Pain Syndrome?

Complex Regional Pain Syndrome (CRPS) is an uncommon, long-term, and often disabling condition that usually impacts one limb (arm, leg, hand, or foot) typically after an injury, surgery, stroke, or heart attack. The main symptom is long-lasting severe pain that can be constant and, in some cases, very uncomfortable or upsetting. The pain is thought to be 'disproportionate' to the seriousness of the initial injury. The cause of CRPS is not yet fully understood.

Typical Symptoms of Complex Regional Pain Syndrome

  • Pain across the entire body

  • Arm pain

  • Thigh pain

  • Always in pain

  • Reduced sweating

  • I experience hot flushes or feelings of overheating

  • Swelling of the affected area

  • Swelling of any body part

Doctor's Diagnostic Questionson Complex Regional Pain Syndrome

Your doctor may ask these questions to check for this disease:

  • Do you have body-wide pain?

  • Are your arms painful?

  • Are your thighs hurting?

  • Do you have constant pain?

  • Do you feel that you are sweating less?

Treatmentof Complex Regional Pain Syndrome

The best way to treat CRPS is to start early. This usually involves a mix of drugs and therapies. Drugs can include things like NSAIDs, corticosteroids, antidepressants, and anticonvulsants. Physical therapy can also help improve movement in the affected limb. Other treatments might be nerve blocks or spinal cord stimulation. Mental health therapy is also a key part of treatment because this condition can greatly affect a person's mental well-being.

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References

  • Bruehl S. Complex regional pain syndrome. BMJ. 2015 Jul 29;351:h2730. doi: 10.1136/bmj.h2730. PMID: 26224572.

    https://www.bmj.com/content/351/bmj.h2730

  • Kessler A, Yoo M, Calisoff R. Complex regional pain syndrome: An updated comprehensive review. NeuroRehabilitation. 2020;47(3):253-264. doi: 10.3233/NRE-208001. PMID: 32986618.

    https://content.iospress.com/articles/neurorehabilitation/nre208001

  • Shim H, Rose J, Halle S, Shekane P. Complex regional pain syndrome: a narrative review for the practising clinician. Br J Anaesth. 2019 Aug;123(2):e424-e433. doi: 10.1016/j.bja.2019.03.030. Epub 2019 May 2. PMID: 31056241; PMCID: PMC6676230.

    https://www.bjanaesthesia.org/article/S0007-0912(19)30235-1/fulltext

  • Neumeister MW, Romanelli MR. Complex Regional Pain Syndrome. Clin Plast Surg. 2020 Apr;47(2):305-310. doi: 10.1016/j.cps.2019.12.009. Epub 2020 Jan 31. PMID: 32115056.

    https://www.plasticsurgery.theclinics.com/article/S0094-1298(19)30123-3/fulltext

  • Urits I, Shen AH, Jones MR, Viswanath O, Kaye AD. Complex Regional Pain Syndrome, Current Concepts and Treatment Options. Curr Pain Headache Rep. 2018 Feb 5;22(2):10. doi: 10.1007/s11916-018-0667-7. PMID: 29404787.

    https://link.springer.com/article/10.1007/s11916-018-0667-7

  • Harden, R. N., Oaklander, A. L., Burton, A. W., Perez, R. S., Richardson, K., Swan, M., ... & Vatine, J. J. (2013). Complex regional pain syndrome: practical diagnostic and treatment guidelines, 4th edition. Pain medicine, 14(2), 180-229.

    https://doi.org/10.1111/pme.12033

  • Maihöfner, C., Seifert, F., & Markovic, K. (2010). Complex regional pain syndromes: new pathophysiological concepts and therapies. European journal of neurology, 17(5), 649-660.

    https://doi.org/10.1111/j.1468-1331.2009.02937.x

  • Complex Regional Pain Syndrome - Mayo Clinic

    https://www.mayoclinic.org/diseases-conditions/crps-complex-regional-pain-syndrome/symptoms-causes/syc-20371151

User Testimonials

Reviewed By:

Unnati Patel, MD, MSc

Unnati Patel, MD, MSc (Family Medicine)

Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.

Shohei Harase, MD

Shohei Harase, MD (Neurology)

Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.

From our team of 50+ doctors

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Think you might have
Complex Regional Pain Syndrome

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