Reviewed By:
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Shohei Harase, MD (Neurology)
Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.
Hiroshi Otake, MD (Anesthesiology)
A 20+years experienced board-certified Anesthesiologist/Critical Care Physician. | An expert in clinical implementation for digital health and machine learning with multi-national clinical experiences in Japan, US and Australia. | Graduated from Master of Science in Clinical Informatics Management at Stanford University in 2022. Served as Professor and Chairman of the Department of Anesthesiology and Vice President of Showa University Hospital, one of the largest academic medical centers in Tokyo, before Stanford. | Introduced the first tele-ICU program in Asia and had business experiences as a management consultant at McKinsey & Company to engage in developing the marketing strategy of new drugs for pharmaceutical companies and standardizing the drug inspection processes for PMDA, a Japanese drug approval agency.
Content updated on Jan 19, 2024
Following the Medical Content Editorial Policy
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Complex Regional Pain Syndrome (CRPS) is an uncommon, long-term, and often disabling condition that usually impacts one limb (arm, leg, hand, or foot) typically after an injury, surgery, stroke, or heart attack. The main symptom is long-lasting severe pain that can be constant and, in some cases, very uncomfortable or upsetting. The pain is thought to be 'disproportionate' to the seriousness of the initial injury. The cause of CRPS is not yet fully understood.
Your doctor may ask these questions to check for this disease:
The best way to treat CRPS is to start early. This usually involves a mix of drugs and therapies. Drugs can include things like NSAIDs, corticosteroids, antidepressants, and anticonvulsants. Physical therapy can also help improve movement in the affected limb. Other treatments might be nerve blocks or spinal cord stimulation. Mental health therapy is also a key part of treatment because this condition can greatly affect a person's mental well-being.
Bruehl S. Complex regional pain syndrome. BMJ. 2015 Jul 29;351:h2730. doi: 10.1136/bmj.h2730. PMID: 26224572.
https://www.bmj.com/content/351/bmj.h2730Kessler A, Yoo M, Calisoff R. Complex regional pain syndrome: An updated comprehensive review. NeuroRehabilitation. 2020;47(3):253-264. doi: 10.3233/NRE-208001. PMID: 32986618.
https://content.iospress.com/articles/neurorehabilitation/nre208001Shim H, Rose J, Halle S, Shekane P. Complex regional pain syndrome: a narrative review for the practising clinician. Br J Anaesth. 2019 Aug;123(2):e424-e433. doi: 10.1016/j.bja.2019.03.030. Epub 2019 May 2. PMID: 31056241; PMCID: PMC6676230.
https://www.bjanaesthesia.org/article/S0007-0912(19)30235-1/fulltextNeumeister MW, Romanelli MR. Complex Regional Pain Syndrome. Clin Plast Surg. 2020 Apr;47(2):305-310. doi: 10.1016/j.cps.2019.12.009. Epub 2020 Jan 31. PMID: 32115056.
https://www.plasticsurgery.theclinics.com/article/S0094-1298(19)30123-3/fulltextUrits I, Shen AH, Jones MR, Viswanath O, Kaye AD. Complex Regional Pain Syndrome, Current Concepts and Treatment Options. Curr Pain Headache Rep. 2018 Feb 5;22(2):10. doi: 10.1007/s11916-018-0667-7. PMID: 29404787.
https://link.springer.com/article/10.1007/s11916-018-0667-7Harden, R. N., Oaklander, A. L., Burton, A. W., Perez, R. S., Richardson, K., Swan, M., ... & Vatine, J. J. (2013). Complex regional pain syndrome: practical diagnostic and treatment guidelines, 4th edition. Pain medicine, 14(2), 180-229.
https://doi.org/10.1111/pme.12033Maihöfner, C., Seifert, F., & Markovic, K. (2010). Complex regional pain syndromes: new pathophysiological concepts and therapies. European journal of neurology, 17(5), 649-660.
https://doi.org/10.1111/j.1468-1331.2009.02937.xComplex Regional Pain Syndrome - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/crps-complex-regional-pain-syndrome/symptoms-causes/syc-20371151Male, 30s
I got more answers in one minute through your site than I did in three hours with Google.
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Male, 20s
My experience was great. I was worried, but the symptom checker helped me narrow down what it might be. I feel a little relieved compared to when I first started, and it gives me a starting point for what my symptoms could mean.
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The questions asked and possible causes seemed spot on, putting me at ease for a next-step solution.
(Sep 26, 2024)
Female, 40s
I was actually very impressed with the results it provided because, although I didn’t mention it during the questionnaire because I thought it was unrelated, it suggested I may have something I’ve actually been diagnosed with in the past.
(Sep 25, 2024)
Reviewed By:
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Shohei Harase, MD (Neurology)
Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.
Hiroshi Otake, MD (Anesthesiology)
A 20+years experienced board-certified Anesthesiologist/Critical Care Physician. | An expert in clinical implementation for digital health and machine learning with multi-national clinical experiences in Japan, US and Australia. | Graduated from Master of Science in Clinical Informatics Management at Stanford University in 2022. Served as Professor and Chairman of the Department of Anesthesiology and Vice President of Showa University Hospital, one of the largest academic medical centers in Tokyo, before Stanford. | Introduced the first tele-ICU program in Asia and had business experiences as a management consultant at McKinsey & Company to engage in developing the marketing strategy of new drugs for pharmaceutical companies and standardizing the drug inspection processes for PMDA, a Japanese drug approval agency.
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