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Stomachache
Upper right abdominal pain
Pain in the upper back
Cannot take a deep breath because of stomach pain
Pain in the middle of the upper stomach
I have a stomachache after eating a greasy meal
Abdominal pain
Not seeing your symptoms? No worries!
Gallbladder stones or pieces of solid material that form in the gallbladder. Many people have gallbladder stones without any symptoms for their entire lives. Severe cases may require surgery.
Your doctor may ask these questions to check for this disease:
This condition does not always need treatment unless it causes problems. If symptoms are present, surgery to remove the gallbladder can be done. If your doctor thinks surgery is risky and the symptoms are mild, a medication may be prescribed.
Reviewed By:
Samantha Nazareth, MD (Gastroenterology)
Board-certified gastroenterologist. Experience managing gastrointestinal conditions (GERD, IBS, ulcerative colitis, Crohn’s, celiac disease, NASH) within healthcare organizations (three ambulatory surgical centers, single-specialty practice, multi-specialty practice and solo practice).
Aiko Yoshioka, MD (Gastroenterology)
Dr. Yoshioka graduated from the Niigata University School of Medicine. He worked as a gastroenterologist at Saiseikai Niigata Hospital and Niigata University Medical & Dental Hospital before serving as the Deputy Chief of Gastroenterology at Tsubame Rosai Hospital and Nagaoka Red Cross Hospital. Dr. Yoshioka joined Saitama Saiseikai Kawaguchi General Hospital as Chief of Gastroenterology in April 2018.
Content updated on Mar 31, 2024
Following the Medical Content Editorial Policy
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With a free 3-min Cholelithiasis quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.
This questionnaire is customized to your situation and symptoms, including the following personal information:
Biological Sex - helps us provide relevant suggestions for male vs. female conditions.
Age - adjusts our guidance based on any age-related health factors.
History - considers past illnesses, surgeries, family history, and lifestyle choices.
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Q.
Sharp Side Pain? Why Cholelithiasis Occurs & Medical Next Steps
A.
Sharp right-sided pain under the ribs is often from gallstones that develop when bile components are imbalanced, bilirubin is elevated, or the gallbladder empties poorly. Attacks often follow fatty meals and can cause nausea with pain radiating to the back or right shoulder; risks include female sex, age over 40, obesity, rapid weight loss, pregnancy, diabetes, family history, and estrogen therapy. See below for next steps, including when to monitor, try lower fat meals, get an ultrasound and blood tests, consider surgery if episodes recur, and seek urgent care for fever, jaundice, persistent severe pain, dark urine, pale stools, or vomiting.
References:
* Krawczyk M, Lammert F. Gallstone disease. Lancet. 2023 Mar 18;401(10380):993-1006. doi: 10.1016/S0140-6736(22)01691-1. PMID: 36934898.
* Fan Z, Song R, Tian H, Wu S, Han F, Guo S, Zhang C, Wei C, Luo X, Song W, Song C. Recent advances in gallstone disease: From mechanism to therapy. Front Pharmacol. 2023 Jan 26;14:1107923. doi: 10.3389/fphar.2023.1107923. PMID: 36776856; PMCID: PMC9912061.
* Portincasa P, Moschetta A, Palasciano G. Gallstone disease: Pathogenesis, diagnosis and treatment. Best Pract Res Clin Gastroenterol. 2020 Feb-Mar;44-45:101671. doi: 10.1016/j.bpg.2020.101671. Epub 2020 May 9. PMID: 32448773.
* Lammert F, Gurusamy K, Ko CW, Miquel JF, Méndez-Sánchez N, Portincasa P, van Erpecum KJ, van Laarhoven CJHM, Wang DQH. Gallstone disease. Nat Rev Dis Primers. 2019 Aug 1;5(1):57. doi: 10.1038/s41572-019-0115-0. PMID: 31371755.
* European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines on the management of gallstones. J Hepatol. 2016 Oct;65(4):817-41. doi: 10.1016/j.jhep.2016.03.005. Epub 2016 Mar 21. PMID: 27042982.
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Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1Gore JM. Cholelithiasis. JAAPA. 2013 Dec;26(12):54-5. doi: 10.1097/01.JAA.0000438244.25450.34. PMID: 24270037.
https://journals.lww.com/jaapa/Citation/2013/12000/Cholelithiasis.12.aspxStokes CS, Lammert F. Transporters in cholelithiasis. Biol Chem. 2012 Jan;393(1-2):3-10. doi: 10.1515/BC-2011-226. PMID: 22628294.
https://www.degruyter.com/document/doi/10.1515/BC-2011-226/htmlAmerican College of Gastroenterology
https://gi.org/topics/gallstones-in-women/