Overview
Both IBS and colon cancer can cause symptoms like abdominal pain, changes in bowel habits, and diarrhea or constipation. However, IBS is a functional disorder that does not cause physical damage, while colon cancer involves abnormal cell growth that can lead to serious complications. A medical evaluation, often including a colonoscopy, is needed to differentiate between the two.
Disease Summaries
IBS: It is a condition with recurring episodes of abdominal discomfort, diarrhea, and constipation. IBS (irritable bowel syndrome) is diagnosed when no clear cause can be found despite investigations. The exact cause of IBS is unknown, but stress and certain foods are known to cause flare-ups.
Colon Cancer: Colon cancer is a growth in the large intestine, often developing from non-cancerous polyps. These can be detected during a colonoscopy. Symptoms may include blood in stool, constipation, diarrhea, or abdominal pain, though it can also be symptomless. Early detection through colonoscopy or stool tests greatly improves treatment outcomes. Risk factors include family or personal history of polyps or colon cancer, low-fiber high-fat diets, obesity, diabetes, certain bowel diseases, and lack of exercise.
Comparing Symptoms
Overlapping Symptoms
- Abdominal pain
- Gas
- Fatigue
- Changes in bowel habits
- Bloating
IBS Specific Symptoms
- Pain relieved by bowel movements
- Symptoms triggered by stress
- Symptoms come and go
- No weight loss
- Mucus in stool
Colon Cancer Specific Symptoms
- Blood in stool
- Unexplained weight loss
- Persistent symptoms
- Narrow stools
- Iron deficiency anemia
Treatment Approaches
IBS Treatment Approaches
Treatment involves dietary modifications to identify and avoid trigger foods, stress management techniques, and medications to control specific symptoms like diarrhea or constipation. Probiotics and fiber supplements may be helpful for some patients. Psychological support through cognitive behavioral therapy can help manage stress-related symptoms.
Colon Cancer Treatment Approaches
In most cases a gastroenterologist will diagnose the tumor with a biopsy during colonoscopy or sigmoidoscopy. They will then order CT scans and MRIs and will refer the patient to a colorectal surgeon. A medical oncologist may be consulted to discuss recommendations for chemotherapy before or after surgery and sometimes a radiation oncologist will give radiotherapy to the area. Since the types of treatment can include surgery, radiation, chemotherapy, or a combination of these, it is often important to be treated by a multidisciplinary team.
Reviewed By:

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Aiko Yoshioka, MD (Gastroenterology)
Dr. Yoshioka graduated from the Niigata University School of Medicine. He worked as a gastroenterologist at Saiseikai Niigata Hospital and Niigata University Medical & Dental Hospital before serving as the Deputy Chief of Gastroenterology at Tsubame Rosai Hospital and Nagaoka Red Cross Hospital. Dr. Yoshioka joined Saitama Saiseikai Kawaguchi General Hospital as Chief of Gastroenterology in April 2018.
Content updated on Mar 27, 2024
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Borghini R, Donato G, Alvaro D, Picarelli A. New insights in IBS-like disorders: Pandora's box has been opened; a review. Gastroenterol Hepatol Bed Bench. 2017 Spring;10(2):79-89. PMID: 28702130; PMCID: PMC5495893.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495893/NCI: Colorectal Cancers, Patient Version
https://www.cancer.gov/types/colorectalColorectal Alliance:What is Colorectal Cancer
https://www.ccalliance.org/colorectal-cancer-information/what-is-colorectal-cancer