Overview
PCOS and endometriosis are both hormonal disorders that can affect menstruation and fertility, but they have distinct causes and symptoms. PCOS is primarily linked to hormone imbalances and often features irregular menstrual cycles, acne, and excess body hair growth. Endometriosis involves the growth of uterine-like tissue outside the uterus, leading to severe pain and heavy bleeding.
Disease Summaries
PCOS: Polycystic Ovary Syndrome or PCOS is a condition that can affect women during their reproductive years. It is generally diagnosed when women have irregular periods (menstrual cycles) along with features of excess male hormones (androgens). Patients typically have evidence of abnormal hair growth on their face, chest or abdomen. They can have multiple cysts (fluid sacs) on their ovaries when looked at by ultrasound. Patients with obesity have an increased risk for PCOS. The exact cause is unknown, but it can run in families and is related to hormonal imbalances (estrogen, insulin, testosterone etc).
Endometriosis: Endometriosis is a condition where endometrial cells (cells that line the womb) grow outside the uterus, typically near the ovaries or fallopian tubes. It is a common cause of pelvic pain, that can worsen with menstruation. The exact cause is unclear but there are several possible explanations, including the backward flow of menstrual blood into the abdominal cavity, immune system disorders, or transformation of normal abdominal cells. It is typically seen in reproductive-aged women, and most often diagnosed in their 30's and 40's. It can cause infertility in some patients due to scarring of the fallopian tubes.
Comparing Symptoms
Overlapping Symptoms
- Irregular or painful periods
- Infertility
- Pelvic pain
- Fatigue
PCOS Specific Symptoms
- Irregular or missed periods
- Excess facial or body hair (hirsutism)
- Acne or oily skin
- Weight gain or difficulty losing weight
- Ovarian cysts
- Insulin resistance
Endometriosis Specific Symptoms
- Severe menstrual cramps
- Pain during or after sex
- Painful bowel movements or urination during periods
- Heavy menstrual bleeding
- Spotting between periods
- Gastrointestinal symptoms (bloating, nausea, constipation)
Treatment Approaches
PCOS Treatment Approaches
The diagnosis must first be confirmed and other conditions such as diabetes and thyroid disorders must be ruled out. With PCOS, lifestyle changes such as losing weight, correcting diabetes and eating better can help. Many patients will need hormonal medications to control their menstrual cycle and reduce future risks. Treatment also can be used to reduce symptoms, such as laser or cream for hair removal. If fertility is desired, the specialist may advise on medications or minor surgeries to improve fertility. If fertility medicines are not effective, surgical procedures may be recommended. Many women can get pregnant with PCOS, sometimes with needed treatment.
Endometriosis Treatment Approaches
Treatment aims to relieve symptoms with a combination of medications and surgery. Medication options include pain relievers, contraceptives, and hormonal therapy. Surgery may be offered for severe disease and may help with infertility.
Reviewed By:

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Seiji Kanazawa, MD, PHD (Obstetrics and Gynecology (OBGYN))
Dr. Kanazawa graduated from the Niigata University Faculty of Medicine and received his Ph.D. from the Tohoku University Graduate School of Medicine. He is working on the front line of the General Perinatal Center, including the Tokyo Tama General Medical Center and the National Center for Research in Fertility Medicine, where he provides maternal and fetal care and undertakes clinical research. At Ubie, Dr. Kanazawa has been designing the Ubie AI Symptom Checker and has taken on the role of general obstetrics and gynecology consultation at FMC Tokyo Clinic by providing fetal ultrasound and prenatal consultation.
Content updated on Apr 27, 2025
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Mehedintu C, Plotogea MN, Ionescu S, Antonovici M. Endometriosis still a challenge. J Med Life. 2014 Sep 15;7(3):349-57. Epub 2014 Sep 25. PMID: 25408753; PMCID: PMC4233437.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233437/Falcone T, Flyckt R. Clinical Management of Endometriosis. Obstet Gynecol. 2018 Mar;131(3):557-571. doi: 10.1097/AOG.0000000000002469. PMID: 29420391.
https://journals.lww.com/greenjournal/Abstract/2018/03000/Clinical_Management_of_Endometriosis.23.aspxKhan MJ, Ullah A, Basit S. Genetic Basis of Polycystic Ovary Syndrome (PCOS): Current Perspectives. Appl Clin Genet. 2019 Dec 24;12:249-260. doi: 10.2147/TACG.S200341. PMID: 31920361; PMCID: PMC6935309.
https://www.dovepress.com/genetic-basis-of-polycystic-ovary-syndrome-pcos-current-perspectives-peer-reviewed-fulltext-article-TACG