Overview
Ulcerative Colitis (UC) and Crohn's Disease are both types of inflammatory bowel disease (IBD), but they affect different areas of the digestive tract. UC is limited to the colon and rectum, involving continuous inflammation of the colon's inner lining. Crohn's can affect any part of the digestive tract from mouth to anus and often occurs in patches, impacting deeper layers of the bowel wall. Both conditions cause abdominal pain, diarrhea, and fatigue, but their progression, complications, and treatment approaches may differ.
Disease Summaries
Ulcerative Colitis: Ulcerative Colitis is an inflammatory condition of the large intestine that damages the gut wall. The exact cause is not well known. It usually begins in the rectum and can extend through the colon, leading to symptoms like bloody diarrhea, abdominal pain, and urgency.
Crohn's Disease: Crohn's Disease is an inflammatory condition of the gut. It can affect anywhere from the mouth to the anus (end of the bowel).The exact cause is not well known. The disease often occurs in patches and can penetrate deeper layers of the bowel wall, causing complications like strictures and fistulas.
Comparing Symptoms
Overlapping Symptoms
- Abdominal pain or cramping
- Chronic diarrhea
- Fatigue
- Weight loss
- Blood in stool
Ulcerative Colitis Specific Symptoms
- Continuous inflammation starting at the rectum and moving upward
- Bloody diarrhea with urgency
- Pain primarily in the lower left abdomen
- Tenesmus (feeling of incomplete bowel movement)
- Symptoms worsen over time in a pattern
Crohn's Disease Specific Symptoms
- Patchy inflammation anywhere in the GI tract
- Diarrhea, sometimes without blood
- Abdominal pain often in the lower right side
- Mouth sores or perianal complications (fissures, fistulas)
- Can cause strictures and malabsorption
Treatment Approaches
Ulcerative Colitis Treatment Approaches
Treatment includes medications to reduce inflammation and suppress the immune system. Lifestyle changes like a modified diet and stress reduction may be helpful. In severe cases, hospitalization for intravenous hydration, and surgery to remove part of the large intestine may be needed.
Crohn's Disease Treatment Approaches
Treatment includes medications to reduce inflammation and suppress the immune system. Antibiotics may be used if there is a pocket of pus (abscess) or fistula present. If medical treatments do not work or if a complication happens, then surgery can be done. Surgery does not cure Crohn's disease.
Reviewed By:

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Aiko Yoshioka, MD (Gastroenterology)
Dr. Yoshioka graduated from the Niigata University School of Medicine. He worked as a gastroenterologist at Saiseikai Niigata Hospital and Niigata University Medical & Dental Hospital before serving as the Deputy Chief of Gastroenterology at Tsubame Rosai Hospital and Nagaoka Red Cross Hospital. Dr. Yoshioka joined Saitama Saiseikai Kawaguchi General Hospital as Chief of Gastroenterology in April 2018.
Content updated on Apr 29, 2025
Following the Medical Content Editorial Policy
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