Drug-Induced Colitis Quiz
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Diarrhea
Have a fever
Stomachache
Blood in stool
Loose stool
Abdominal pain
My body is hot
Not seeing your symptoms? No worries!
What is Drug-Induced Colitis?
Inflammation of the large intestines can be caused by various drugs, with non-steroidal anti-inflammatory drugs (NSAIDs) being the most common.
Typical Symptoms of Drug-Induced Colitis
- Blood in stool
- Fever
- History of chemotherapy in the last one year
- Taking omeprazole and similar medication for gastritis or reflux
- Stomach or abdominal pain
- Diarrhea or loose stools
- Loss of appetite
- History of cancer
Diagnostic Questions for Drug-Induced Colitis
Your doctor may ask these questions to check for this disease:
- Have you noticed any blood in your stool?
- Do you have a fever?
- Did you have cancer treatment in the past year?
- Are you taking any medication to reduce gastric acid?
- Do you have any stomach or abdominal pain?
Treatment of Drug-Induced Colitis
In some cases, stopping the problematic medicine is enough for recovery. In severe cases, medications like steroids may be necessary to manage the inflammation.
Reviewed By:
Maxwell J. Nanes, DO (Emergency Medicine)
Dr Nanes received a doctorate from the Chicago College of Osteopathic Medicine and went on to complete a residency in emergency medicine at the Medical College of Wisconsin. There he trained at Froedtert Hospital and Children's Hospital of Wisconsin in the practice of adult and pediatric emergency medicine. He was a chief resident and received numerous awards for teaching excellence during his time there. | | After residency he took a job at a community hospital where he and his colleagues worked through the toughest days of the COVID-19 pandemic. |
Content updated on Feb 13, 2025
Following the Medical Content Editorial Policy
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- Stools looks like strawberry jam
- Stool looks like raspberry jelly
- Poop looks like strawberry jam
- Poo looks like currant jelly
- Recurrent fevers
- Blood and mucus in stool
- Stool looks like jelly
- Periodic fever (>100.4°F / 38°C)
- Bloody diarrhea
- Red sticky poo
- I have lower abdominal pain
- Fever then no fever then fever again
- Remittent fever of 102.2°F / 39°C
- Extremely high fever of 106.7°F / 41.5°C or higher
- I have left lower abdominal pain
See full list
Symptoms Related to Drug-Induced Colitis
Diseases Related to Drug-Induced Colitis
FAQs
Q.
Side effects of experimental IBD drugs? Why your gut is failing & new clinical steps.
A.
Key side effects of newer and experimental IBD drugs include infections, GI symptoms that can mimic true flares including drug induced colitis, blood clots with some JAK inhibitors, liver and cholesterol changes, and injection or infusion reactions, with long term cancer risk still under study. If your gut is still failing, causes may include a mismatch to your immune profile, anti drug antibodies, overlapping inflammatory pathways, or an infection while immunosuppressed; modern care addresses this with careful screening and monitoring plus new clinical steps like precision matching, combination approaches, microbiome strategies, and earlier aggressive treatment. There are several factors to consider; see below for red flags, monitoring plans, and decision points that can change your next steps, including when to check for drug induced colitis and when to call your care team.
References:
* Singh S, et al. New and emerging therapies for inflammatory bowel diseases: what is on the horizon? Expert Rev Clin Immunol. 2021 Jan;17(1):19-35. doi: 10.1080/1744666X.2021.1852654. Epub 2020 Nov 29. PMID: 33207909.
* Maloy KJ, et al. The intestinal epithelial barrier in inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2021 Feb;18(2):77-91. doi: 10.1038/s41575-020-00366-4. Epub 2020 Nov 16. PMID: 33199898; PMCID: PMC7856108.
* Gecse KB, et al. New therapeutic approaches in inflammatory bowel diseases beyond TNFα. Lancet Gastroenterol Hepatol. 2020 Feb;5(2):191-203. doi: 10.1016/S2468-1253(19)30342-1. Epub 2019 Nov 27. PMID: 31787595.
* Roda G, et al. Emerging Treatment Modalities for Inflammatory Bowel Disease. Gastroenterology. 2020 Mar;158(4):1122-1136. doi: 10.1053/j.gastro.2019.12.030. Epub 2020 Jan 9. PMID: 31926227.
* Liu Z, et al. Gut microbiota-targeted therapies for inflammatory bowel disease: recent advances and future perspectives. Gut Microbes. 2023 Jan-Dec;14(1):2171241. doi: 10.1080/19490976.2023.2171241. PMID: 36762391; PMCID: PMC9930776.
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Nielsen, O. H., Fernandez-Banares, F., Sato, T., & Pardi, D. S. (2022). Microscopic colitis: Etiopathology, diagnosis, and rational management. Elife.
https://elifesciences.org/articles/79397Suzuki, K., Kakuta, Y., Naito, T., Takagawa, T., ... (2022). Genetic background of mesalamine-induced fever and diarrhea in Japanese patients with inflammatory bowel disease. Inflammatory bowel …
https://academic.oup.com/ibdjournal/article-abstract/28/1/21/6121230Antonatos, C., Stavrou, E. F., Evangelou, E., ... (2021). Exploring pharmacogenetic variants for predicting response to anti-TNF therapy in autoimmune diseases: A meta-analysis. Taylor & Francis.
https://www.tandfonline.com/doi/abs/10.2217/pgs-2021-0019