Familial Amyloid Polyneuropathy Quiz

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Shohei Harase, MD


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Learn more about Familial amyloid polyneuropathy

Content updated on Sep 20, 2022

What is familial amyloid polyneuropathy?

Familial amyloid polyneuropathy (FAPs) are a group of life-threatening multisystem inherited disorders in which amyloid (abnormal protein that can be deposited in any tissue) deposit in the nerve fibers and around the nerves.

Symptoms of familial amyloid polyneuropathy

  • Decreased sensation over skin

  • Feel the heart is pounding

  • Numbness anywhere from the knees to the ankles

  • Numbness or abnormal sensation

  • Leg or foot numbness

  • Unable to move both legs

  • Dizziness

  • Weakness in arms or legs

Questions your doctor may ask to check for familial amyloid polyneuropathy

Your doctor may ask these questions to diagnose familial amyloid polyneuropathy

  • Do you feel the sensation on your skin has changed?

  • Do you feel your heart is pounding?

  • Do you have numbness from your knees down (such as ankles)?

  • Do you feel any numbness or change in sensation?

  • Do you have numbness in your feet?

Treatment for familial amyloid polyneuropathy

Pain due to familial amyloid polyneuropathy can be treated with anti-seizure medications, antidepressants, or pain killers including opiate drugs. Almost all amyloid in the bloodstream are made in the liver. Hence, liver transplant may be considered to prevent further amyloid deposits.

View the symptoms of Familial amyloid polyneuropathy


Medically Reviewed By:

From our team of 50+ doctors

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Shohei Harase

Shohei Harase, MD


Kameda Medical Center, Japan

Sanshiro Kato

Sanshiro Kato, MD

Emergency department

Kawai Clinic, Japan

Yu Shirai

Yu Shirai, MD


Yotsuya Yui Clinic, Japan

Yoshinori Abe

Yoshinori Abe, MD

Internal medicine

Co-founder of Ubie, Inc.

Rohini R

Rohini R, MD

Ear, nose, throat (ENT)

Bayshore Health Centre, India

Seiji Kanazawa

Seiji Kanazawa, MD, PHD

Obstetrics and gynecology (OBGYN)

National Center for Child Health and Development, Japan

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