Familial Amyloid Polyneuropathy Quiz
Check your symptoms and
find possible causes with AI for free
Reviewed By:
Benjamin Kummer, MD (Neurology)
Dr Kummer is Assistant Professor of Neurology at the Icahn School of Medicine at Mount Sinai (ISMMS), with joint appointment in Digital and Technology Partners (DTP) at the Mount Sinai Health System (MSHS) as Director of Clinical Informatics in Neurology. As a triple-board certified practicing stroke neurologist and informaticist, he has successfully improved clinical operations at the point of care by acting as a central liaison between clinical neurology faculty and DTP teams to implement targeted EHR configuration changes and workflows, as well as providing subject matter expertise on health information technology projects across MSHS. | Dr Kummer also has several years’ experience building and implementing several informatics tools, presenting scientific posters, and generating a body of peer-reviewed work in “clinical neuro-informatics” – i.e., the intersection of clinical neurology, digital health, and informatics – much of which is centered on digital/tele-health, artificial intelligence, and machine learning. He has spearheaded the Clinical Neuro-Informatics Center in the Department of Neurology at ISMMS, a new research institute that seeks to establish the field of clinical neuro-informatics and disseminate knowledge to the neurological community on the effects and benefits of clinical informatics tools at the point of care.
Shohei Harase, MD (Neurology)
Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.
Content updated on Mar 31, 2024
Following the Medical Content Editorial Policy
Worried about your symptoms?
Choose one to start our AI Symptom Checker.
It will help us optimize further questions for you.
By starting the symptom checker, you agree to the Privacy Policy and Terms of Use
Find another symptom
How Ubie Can Help You
With an easy 3-min questionnaire , Ubie's AI-powered system will generate a free report on possible causes.
Questions are customized to your situation and symptoms, including the following personal information:
Biological Sex - helps us provide relevant suggestions for male vs. female conditions.
Age - adjusts our guidance based on any age-related health factors.
History - considers past illnesses, surgeries, family history, and lifestyle choices.
Your symptoms
Our AI
Your report
Your personal report will tell you
✔︎ When to see a doctor
✔︎ What causes your symptoms
✔︎ Treatment information etc.
People with similar symptoms also use Ubie's symptom checker to find possible causes
My body is jerking
Twitching
Fever seizures (with fever of >100.4°F / 38°C)
The first seizure
Repetitive seizures
Seizure with fainting
I have a seizure that is not symmetric
Just 3 minutes.
Developed by doctors.
What is Familial Amyloid Polyneuropathy?
Familial amyloid polyneuropathy (FAPs) are life-threatening, multisystem, inherited disorders where amyloid (an abnormal protein that can be deposited in any tissue) accumulates in nerve fibers and around nerves.
Typical Symptoms of Familial Amyloid Polyneuropathy
Seizure
Numbness anywhere from the knees to the ankles
Unable to move both legs
Dizziness
Tingling or pricking numbness in the legs even when keeping still
Reduced sensitivity to feeling pain
Reduced sweating
Difficulty achieving or maintaining an erection
Doctor's Diagnostic Questionson Familial Amyloid Polyneuropathy
Your doctor may ask these questions to check for this disease:
Have you had a seizure?
Do you have numbness in your lower legs?
Are you unable to move both legs?
Are you currently dizzy?
Do you have tingling or numbness in your legs even when you're not moving?
Treatmentof Familial Amyloid Polyneuropathy
Pain from familial amyloid polyneuropathy can be treated with anti-seizure medications, antidepressants, or painkillers, including opiate drugs. Almost all amyloid in the bloodstream is made in the liver, so a liver transplant may be considered to prevent further amyloid deposits.
Think you might have
Familial Amyloid Polyneuropathy
View the symptoms of Familial Amyloid Polyneuropathy
Diseases related to Familial Amyloid Polyneuropathy
References
Planté-Bordeneuve V, Said G. Familial amyloid polyneuropathy. Lancet Neurol. 2011 Dec;10(12):1086-97. doi: 10.1016/S1474-4422(11)70246-0. PMID: 22094129.
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(11)70246-0/fulltext
Adams D, Cauquil C, Labeyrie C. Familial amyloid polyneuropathy. Curr Opin Neurol. 2017 Oct;30(5):481-489. doi: 10.1097/WCO.0000000000000476. PMID: 28678039.
https://journals.lww.com/co-neurology/Abstract/2017/10000/Familial_amyloid_polyneuropathy.7.aspx
Conceição I, González-Duarte A, Obici L, Schmidt HH, Simoneau D, Ong ML, Amass L. "Red-flag" symptom clusters in transthyretin familial amyloid polyneuropathy. J Peripher Nerv Syst. 2016 Mar;21(1):5-9. doi: 10.1111/jns.12153. PMID: 26663427; PMCID: PMC4788142.
https://onlinelibrary.wiley.com/doi/10.1111/jns.12153
Barreiros AP, Galle PR, Otto G. Familial amyloid polyneuropathy. Dig Dis. 2013;31(1):170-4. doi: 10.1159/000347214. Epub 2013 Jun 17. PMID: 23797140.
https://www.karger.com/Article/Abstract/347214
User Testimonials
Reviewed By:
Benjamin Kummer, MD (Neurology)
Dr Kummer is Assistant Professor of Neurology at the Icahn School of Medicine at Mount Sinai (ISMMS), with joint appointment in Digital and Technology Partners (DTP) at the Mount Sinai Health System (MSHS) as Director of Clinical Informatics in Neurology. As a triple-board certified practicing stroke neurologist and informaticist, he has successfully improved clinical operations at the point of care by acting as a central liaison between clinical neurology faculty and DTP teams to implement targeted EHR configuration changes and workflows, as well as providing subject matter expertise on health information technology projects across MSHS. | Dr Kummer also has several years’ experience building and implementing several informatics tools, presenting scientific posters, and generating a body of peer-reviewed work in “clinical neuro-informatics” – i.e., the intersection of clinical neurology, digital health, and informatics – much of which is centered on digital/tele-health, artificial intelligence, and machine learning. He has spearheaded the Clinical Neuro-Informatics Center in the Department of Neurology at ISMMS, a new research institute that seeks to establish the field of clinical neuro-informatics and disseminate knowledge to the neurological community on the effects and benefits of clinical informatics tools at the point of care.
Shohei Harase, MD (Neurology)
Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.
Think you might have
Familial Amyloid Polyneuropathy
Ubie is supervised by 50+ medical experts worldwide
Our symptom checker AI is continuously refined with input from experienced physicians, empowering them to make more accurate diagnoses.
Dale Mueller, MD
Cardiothoracic Surgery, Vascular Surgery
Cardiothoracic and Vascular Surgery Associates
