Rheumatoid Arthritis (RA) Quiz

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Joint pain

Fatigue

Swollen joints in fingers

Joint inflammation

Hip joint pain

Big toe joint pain

Joint pain and stiffness all over body

Pain in both hands

Ankle pain and swelling without injury

Knee inflammation

Stiff joints

Not seeing your symptoms? No worries!

What is Rheumatoid Arthritis (RA)?

A chronic inflammatory disease where the body's immune system attacks multiple joints, most commonly in the hands and feet. The cause and trigger is unknown.

Typical Symptoms of Rheumatoid Arthritis (RA)

Diagnostic Questions for Rheumatoid Arthritis (RA)

Your doctor may ask these questions to check for this disease:

  • Do you have pain all over your body?
  • Do you have warm hands and feet?
  • Are you currently taking steroids?
  • Do you feel small lumps on your elbows, head, or buttocks (pea to bean size)?
  • Are you experiencing pain in your finger?

Treatment of Rheumatoid Arthritis (RA)

Treatment aims to reduce inflammation and long-term joint damage. Patients may be prescribed immune-suppressing medications and anti-inflammatory medications for pain. Physical exercise is also important for maintaining muscle strength and joint mobility. Smoking cessation and attention to diet are recommended.

Reviewed By:

Kenji Taylor, MD, MSc

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)

Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Kaito Nakamura, MD

Kaito Nakamura, MD (Rheumatology)

Dr. Nakamura is a rheumatologist who has practiced in the Ota Nishinouchi Hospital attached to Ota General Hospital, National Health Insurance Matsudo City Hospital, Chiba University Hospital, and the National Health Insurance Asahi Central Hospital.

From our team of 50+ doctors

Content updated on Feb 19, 2025

Following the Medical Content Editorial Policy

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With a free 3-min Rheumatoid Arthritis (RA) quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.

This questionnaire is customized to your situation and symptoms, including the following personal information:

  • Biological Sex - helps us provide relevant suggestions for male vs. female conditions.

  • Age - adjusts our guidance based on any age-related health factors.

  • History - considers past illnesses, surgeries, family history, and lifestyle choices.

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User Testimonials for Rheumatoid Arthritis (RA)

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Female, 40s

Ubie gave me a direction to go in when looking into possible autoimmune immune symptoms. I found it very helpful. I now plan on booking an appointment and seeing a doctor soon.

(Jun 14, 2025)

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Female, 30s

The downloadable symptoms list is a game-changer for me. Also, the suggestions for narrowing down on possible conditions. I found this website to be supremely helpful for me today with what I needed to accomplish. Thank you. I will book an appointment and see a doctor right away.

(Jun 12, 2025)

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Female, 50s

A few of the predictions Ubie made based on my symptoms make a lot of sense to me. Especially with the rheumatoid problems I have and the fact I always show a lot of inflammation when I get blood work done.

(May 16, 2025)

Symptoms Related to Rheumatoid Arthritis (RA)

Diseases Related to Rheumatoid Arthritis (RA)

FAQs

Q.

Everything you need to know about rheumatoid arthritis

A.

Rheumatoid arthritis is a chronic autoimmune disease that causes symmetrical joint pain, swelling, and morning stiffness and, without early treatment, can lead to permanent joint damage and other systemic complications. There are several factors to consider—how it’s diagnosed (RF/anti-CCP and imaging), evidence-based treatments (DMARDs, biologics, JAK inhibitors), lifestyle and monitoring plans, vaccine and safety guidance, and urgent red flags—see below for complete details and which next steps to take.

References:

D’Amico G, Garcia-Tsao G, Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies… J Hepatol, 16310473.

https://pubmed.ncbi.nlm.nih.gov/16310473/

Tsochatzis EA, Bosch J, Burroughs AK. (2014). Liver cirrhosis… Lancet, 24569018.

https://pubmed.ncbi.nlm.nih.gov/24569018/

Ginès P, Cárdenas A, Arroyo V, Rodés J. (2004). Management of cirrhosis and ascites… N Engl J Med, 15356322.

https://pubmed.ncbi.nlm.nih.gov/15356322/

See more on Doctor's Note

Q.

Experiencing rheumatoid arthritis symptoms? These are the steps to take

A.

Rheumatoid arthritis symptoms: track them daily, try an online symptom check, and book a prompt medical visit—ideally with a rheumatologist—for evaluation with RF/anti‑CCP, ESR/CRP, and imaging. Early treat‑to‑target therapy (DMARDs like methotrexate, short‑term NSAIDs/steroids, or biologics) plus lifestyle measures can slow progression; seek urgent care for high fever, infection signs while on immunosuppressants, chest pain, or sudden severe joint pain. There are several factors that can change your next steps—diagnostic criteria, what to bring to your visit, monitoring frequency, and more—see below for the complete details.

References:

Aletaha D, Neogi T, Silman AJ, et al. (2010). 2010 Rheumatoid arthritis classification criteria: an American College… Arthritis Rheum, 20872595.

https://pubmed.ncbi.nlm.nih.gov/20872595/

Smolen JS, Landewe R, Breedveld FC, et al. (2014). 2013 update of the EULAR recommendations for the management… Ann Rheum Dis, 24356502.

https://pubmed.ncbi.nlm.nih.gov/24356502/

Tsochatzis EA, Germani G, Burroughs AK. (2014). Liver stiffness measurement in the diagnosis and monitoring… Hepatol Int, 24714956.

https://pubmed.ncbi.nlm.nih.gov/24714956/

See more on Doctor's Note

Q.

How to cure rheumatoid arthritis permanently

A.

There’s currently no permanent cure for rheumatoid arthritis, but many people achieve sustained remission with early diagnosis (ideally within 12 weeks), a treat‑to‑target plan using DMARDs and, if needed, biologics or JAK inhibitors, plus exercise, diet, and smoking cessation. Ongoing safety monitoring, vaccinations, and timely therapy adjustments are key, with tapering only after stable remission. There are several factors to consider—see below for complete guidance that could influence your next steps and when to involve a rheumatologist.

References:

Felson DT, & Smolen JS. (2011). American College of Rheumatology/European League Against Rheumatism provisional definition of remission in… Ann Rheum Dis, 21498589.

https://pubmed.ncbi.nlm.nih.gov/21498589/

McInnes IB, & Schett G. (2017). Pathogenetic insights from the treatment of rheumatoid arthritis. Nat Rev Rheumatol, 28153918.

https://pubmed.ncbi.nlm.nih.gov/28153918/

D'Amico G, & Garcia-Tsao G. (2006). Natural history and prognostic indicators of survival in cirrhosis with… Journal of Hepatology, 16427604.

https://pubmed.ncbi.nlm.nih.gov/16427604/

See more on Doctor's Note

Q.

Is rheumatoid arthritis an autoimmune disease?

A.

Yes—rheumatoid arthritis is a chronic, systemic autoimmune disease in which the immune system attacks the joint lining (synovium), causing inflammation, pain, stiffness, and progressive joint damage if untreated. There are several factors to consider, including hallmark symptoms, autoantibody testing (RF, anti-CCP), imaging, treatment options, and the importance of early rheumatology care—see below for key details that could inform your next steps.

References:

McInnes IB, & Schett G. (2011). The pathogenesis of rheumatoid arthritis. N Engl J Med, 21410306.

https://pubmed.ncbi.nlm.nih.gov/21410306/

Tsochatzis EA, Bosch J, & Burroughs AK. (2014). Liver cirrhosis. Lancet, 24342547.

https://pubmed.ncbi.nlm.nih.gov/24342547/

Stefanescu H, et al. (2017). Liver stiffness measurement predicts decompensation and death… J Hepatol, 28314596.

https://pubmed.ncbi.nlm.nih.gov/28314596/

See more on Doctor's Note

Q.

Is rheumatoid arthritis genetic?

A.

Rheumatoid arthritis has a significant genetic component—about 60% of overall risk is inherited (not from a single “RA gene”), with variants like HLA-DRB1 and PTPN22 involved—but genes don’t determine destiny. Environmental factors such as smoking (the strongest modifiable risk), gum disease, hormones, and weight interact with those genes, so having a close relative with RA roughly doubles risk, yet most relatives never develop it. There are several factors to consider, including early symptoms and risk-reduction steps; see below for the complete answer and guidance on next steps.

References:

MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, Thomson W, & Silman AJ. (2000). Characterizing the quantitative genetic contribution to… Arthritis Rheum, 10610590

https://pubmed.ncbi.nlm.nih.gov/10610590/

Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Stein CM, & et al. (2004). A missense single-nucleotide polymorphism in a gene encoding… Nat Genet, 15004583

https://pubmed.ncbi.nlm.nih.gov/15004583/

Sandrin L, Fourquet B, Hasquenoph JM, Ziol M, Poujol-Robert A, Roux P, & et al. (2003). Transient elastography: a new noninvasive method for assessment of… Ultrasound Med Biol, 14680684

https://pubmed.ncbi.nlm.nih.gov/14680684/

See more on Doctor's Note

Q.

Is there a way to cure rheumatoid arthritis permanently?

A.

There is currently no permanent cure for rheumatoid arthritis, but many people can achieve long-term remission and maintain quality of life with early, treat-to-target care. Most require ongoing DMARDs (sometimes biologics or JAK inhibitors) plus lifestyle changes, and stopping therapy often triggers flares; experimental immune-reset approaches remain investigational. There are several factors to consider—see below for key details that could affect your next steps, including treatment choices, monitoring, and when to seek urgent care.

References:

Smolen JS, Landewé R, Bijlsma JWJ, et al. (2020). EULAR recommendations for the management of rheuma… Ann Rheum Dis, 31689605.

https://pubmed.ncbi.nlm.nih.gov/31689605/

Felson DT, Smolen JS, Wells G, et al. (2011). American College of Rheumatology/European League… Arthritis Rheum, 19165910.

https://pubmed.ncbi.nlm.nih.gov/19165910/

D'Amico G, Garcia‐Tsao G, & Pagliaro L. (2006). Natural history and prognostic indicators of surviva… J Hepatol, 11707698.

https://pubmed.ncbi.nlm.nih.gov/11707698/

See more on Doctor's Note

Q.

Top 5 things people get wrong about rheumatoid arthritis symptoms

A.

The top myths include thinking RA is just wear-and-tear, that it only affects hands/feet, that it’s always symmetrical, that morning stiffness is brief, and that it only occurs in older adults—RA is autoimmune, can involve many organs, may start unevenly, typically causes 30+ minutes of stiffness, and can occur at any age. These details change diagnosis and urgency; if you have persistent swelling/warmth, long morning stiffness, or systemic symptoms, seek medical evaluation—see the complete explanations and next-step guidance below.

References:

Smolen JS, Aletaha D, & McInnes IB. (2016). Rheumatoid arthritis. Lancet, 27156401.

https://pubmed.ncbi.nlm.nih.gov/27156401/

Aletaha D, Neogi T, Silman AJ, et al. (2010). 2010 rheumatoid arthritis classification criteria: an American… Arthritis Rheum, 20872595.

https://pubmed.ncbi.nlm.nih.gov/20872595/

Tsochatzis EA, Bosch J, & Burroughs AK. (2014). Liver cirrhosis. Lancet, 24613313.

https://pubmed.ncbi.nlm.nih.gov/24613313/

See more on Doctor's Note

Q.

What are the 4 stages of rheumatoid arthritis?

A.

The four stages of rheumatoid arthritis are: Stage I (early, synovitis without X-ray damage), Stage II (moderate, joint space narrowing and periarticular bone loss), Stage III (severe, erosions and deformities), and Stage IV (end-stage, ankylosis/collapse with major loss of function). There are several factors to consider—testing, medication choices (DMARDs/biologics), rehab and surgical options, and complication risks—see below for details that can guide your next steps.

References:

Steinbrocker R, & Traeger CH. (1949). Therapeutic criteria in rheumatoid arthritis. JAMA, 18106251.

https://pubmed.ncbi.nlm.nih.gov/18106251/

McInnes IB, & Schett G. (2011). The pathogenesis of rheumatoid arthritis. N Engl J Med, 22187956.

https://pubmed.ncbi.nlm.nih.gov/22187956/

D'Amico G, Garcia-Tsao G, & Pagliaro L. (2006). Natural history and prognostic indicators of survival in cir… J Hepatol, 16875776.

https://pubmed.ncbi.nlm.nih.gov/16875776/

See more on Doctor's Note

Q.

What is rheumatoid arthritis?

A.

Rheumatoid arthritis is a chronic autoimmune disease in which the immune system attacks the lining of the joints, causing painful swelling, morning stiffness, and progressive damage; it often affects both sides of the body and can involve organs like the heart, lungs, and eyes. There are several factors to consider—how it’s diagnosed (RF/ACPA blood tests and imaging), why early DMARD treatment matters, and when symptoms signal urgent care—see below for key details that can guide your next steps.

References:

Smolen JS, Aletaha D, & McInnes IB. (2016). Rheumatoid arthritis. Lancet, 27638933.

https://pubmed.ncbi.nlm.nih.gov/27638933/

Aletaha D, Neogi T, Silman AJ, et al. (2010). 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis & Rheumatism, 20628081.

https://pubmed.ncbi.nlm.nih.gov/20628081/

D'Amico G, Garcia-Tsao G, & Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. Journal of Hepatology, 16122867.

https://pubmed.ncbi.nlm.nih.gov/16122867/

See more on Doctor's Note

Q.

What is the best medication for rheumatoid arthritis pain?

A.

There isn’t one “best” medication—pain is best relieved by controlling inflammation: methotrexate is the usual first-line disease‑modifying therapy, with NSAIDs or short steroid courses as bridges, and biologics or JAK inhibitors if conventional DMARDs don’t meet targets. The right choice depends on disease activity, side‑effect risks, pregnancy plans, monitoring needs, and cost, so work with a rheumatologist; key safety checks, dosing, and escalation steps are explained below.

References:

Smolen JS, Landewé R, Breedveld FC, Buch M, Burmester G, Dougados M, Emery P, Gaujoux-Viala C, Gossec L, Nam JL, et al. (2014). 2013 update of EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological… Ann Rheum Dis, 24319055.

https://pubmed.ncbi.nlm.nih.gov/24319055/

Hazlewood GS, Barnabe C, Tomlinson G, Marshall D, Devoe DJ, Bombardier C. (2016). Methotrexate monotherapy and methotrexate combination therapy with traditional and biological… Ann Rheum Dis, 27264142.

https://pubmed.ncbi.nlm.nih.gov/27264142/

European Association for the Study of the Liver. (2015). EASL-ALEH clinical practice guidelines: non-invasive tests for the evaluation of liver disease… Journal of Hepatology, 25856827.

https://pubmed.ncbi.nlm.nih.gov/25856827/

See more on Doctor's Note

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References