Worried about your symptoms?
Start the IgG4-Related Skin Disease test with our free AI Symptom Checker.
This will help us personalize your assessment.
By starting the symptom checker, you agree to the Privacy Policy and Terms of Use
Red spots on skin
Skin redness
Rash on skin
Skin abnormality
Skin lesions
Itchy patches of skin
Bumps on skin
Not seeing your symptoms? No worries!
Immunoglobulin G4-related disease is linked to unregulated immune system responses and can affect the skin. It can appear in various ways on the skin, and other organs may also be affected by IgG4-RD. It affects men more than women and is more common in older adults than in young people.
Your doctor may ask these questions to check for this disease:
Treatment may include taking immunosuppressant medication and/or surgically removing the affected skin part.
Reviewed By:
Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.
Yukiko Ueda, MD (Dermatology)
Dr. Ueda graduated from the Niigata University School of Medicine and trained at the University of Tokyo Medical School. She is currently a clinical assistant professor at the Department of Dermatology, Jichi Medical University, and holds several posts in the dermatology departments at Kyoto Prefectural University of Medicine, Komagome Hospital, University of Tokyo, and the Medical Center of Japan Red Cross Society.
Content updated on Jan 29, 2025
Following the Medical Content Editorial Policy
Was this page helpful?
We would love to help them too.
With a free 3-min IgG4-Related Skin Disease quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.
This questionnaire is customized to your situation and symptoms, including the following personal information:
Biological Sex - helps us provide relevant suggestions for male vs. female conditions.
Age - adjusts our guidance based on any age-related health factors.
History - considers past illnesses, surgeries, family history, and lifestyle choices.
Your symptoms
Our AI
Your report
Your personal report will tell you
✔ When to see a doctor
✔︎ What causes your symptoms
✔︎ Treatment information etc.
See full list
Our symptom checker AI is continuously refined with input from experienced physicians, empowering them to make more accurate diagnoses.
“World’s Best Digital
Health Companies”
Newsweek 2024
“Best With AI”
Google Play Best of 2023
“Best in Class”
Digital Health Awards 2023 (Quarterfinalist)
Which is the best Symptom Checker?
Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1Brody G, Nguyen MO, Rojek NW, Lee BA. A unique case of IgG4-related skin disease and sclerosing cholangitis in a patient with previous hepatitis exposure. JAAD Case Rep. 2021 Jul 24;15:52-55. doi: 10.1016/j.jdcr.2021.07.008. PMID: 34401431; PMCID: PMC8355813.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8355813/Sato, Y., Takeuchi, M., Takata, K. et al. Clinicopathologic analysis of IgG4-related skin disease. Mod Pathol 26, 523–532 (2013).
https://www.nature.com/articles/modpathol2012196Afra TP, Razmi TM, Bishurul Hafi NA. IgG4-related skin diseases: A brief review. J Skin Sex Transm Dis 2020;2(2):94-8.
https://jsstd.org/igg4-related-skin-diseases-a-brief-review/