Juvenile Myoclonic Epilepsy (Janz Syndrome) Quiz

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Unnati Patel, MD, MSc

Unnati Patel, MD, MSc (Family Medicine)

Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.

Shohei Harase, MD

Shohei Harase, MD (Neurology)

Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.

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  • Left hand and leg jerks for a while after I wake up

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What is Juvenile Myoclonic Epilepsy (Janz Syndrome)?

Juvenile myoclonic epilepsy (Janz syndrome) is an epilepsy syndrome marked by the presence of absence, myoclonic, and generalized tonic-clonic (GTC) seizures. All patients with JME have myoclonic seizures, 85%-90% of patients have generalized tonic-clonic seizures, and about 20-40% of patients have absence seizures. These often happen when people first wake up in the morning. The exact cause is unknown, but a family history of epilepsy or gene mutations may sometimes be connected to the condition.

Typical Symptoms of Juvenile Myoclonic Epilepsy (Janz Syndrome)

  • The hand or leg on one side occasionally jerks or makes a sudden movement

  • Limbs on one side of the body jerk when / just after waking up

  • Lost consciousness when drinking alcohol or hungover

  • Lose consciousness when sleep deprived

Doctor's Diagnostic Questionson Juvenile Myoclonic Epilepsy (Janz Syndrome)

Your doctor may ask these questions to check for this disease:

  • Do your limbs jerk upon waking up?

  • Do you black out when drinking alcohol or hungover?

  • Can lack of sleep cause loss of consciousness?

Treatmentof Juvenile Myoclonic Epilepsy (Janz Syndrome)

Juvenile myoclonic epilepsy (Janz syndrome) is typically well managed with medications for seizures. Most patients don't outgrow their seizures and will need to take medication for the rest of their lives. Getting enough sleep, avoiding alcohol, fatigue and anxiety can help lower the chances of seizures.

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View the symptoms of Juvenile Myoclonic Epilepsy (Janz Syndrome)

  • Involuntary muscle jerks

Diseases related to Juvenile Myoclonic Epilepsy (Janz Syndrome)

References

  • Bittermann HJ, Steinhoff BJ. Die juvenile myoklonische Epilepsie (Janz-Syndrome). Ein gut bekanntes Epilepsiesyndrom? [Juvenile myoclonic epilepsy (Janz syndrome). A well-known epilepsy syndrome?]. Nervenarzt. 1998 Feb;69(2):127-30. German. doi: 10.1007/s001150050248. PMID: 9551456.

    https://pubmed.ncbi.nlm.nih.gov/9551456/#:~:text=Juvenile%20myoclonic%20epilepsy%20(JME)%20was,deprivation%2C%20alcohol%20consumption%20and%20flickering

  • Amrutkar CV, Riel-Romero RM. Juvenile Myoclonic Epilepsy. [Updated 2023 Feb 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537109/

    https://www.ncbi.nlm.nih.gov/books/NBK537109/#:~:text=Juvenile%20myoclonic%20epilepsy%20(JME)%2C,Lund%20in%201975%20as%20JME.

User Testimonials

Reviewed By:

Unnati Patel, MD, MSc

Unnati Patel, MD, MSc (Family Medicine)

Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.

Shohei Harase, MD

Shohei Harase, MD (Neurology)

Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.

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