Juvenile Myoclonic Epilepsy (Janz Syndrome) Quiz

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Unnati Patel, MD, MSc

Unnati Patel, MD, MSc (Primary Care Physician)

Dr Patel graduated from the Zhejiang University School of Medicine. She worked in clinical research at the University of Illinois in Chicago and University of Nevada in Las Vegas focused on culturally adapted health interventions for preventive medicine in the community setting. Received her Master's of Science in Global Health (concentration in Health Policy) from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. Unnati went on to complete her family medicine residency in Chicago, Illinois at Norwegian American Hospital. | | She is currently working as a primary care physician in the city of Chicago and completing her Master's of Business Administration at the Northwestern University Kellogg School of Management and Fellowship in Leadership in Value-Based Care.

Shohei Harase, MD

Shohei Harase, MD (Neurology)

Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.

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  • Left hand and leg jerks for a while after I wake up

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Learn more about Juvenile Myoclonic Epilepsy (Janz Syndrome)

Content updated on Jan 30, 2024

What is juvenile myoclonic epilepsy (Janz syndrome)?

Juvenile myoclonic epilepsy (Janz syndrome) is an epilepsy syndrome marked by the presence of absence, myoclonic, and generalized tonic-clonic (GTC) seizures. All patients with JME have myoclonic seizures, 85%-90% of patients have generalized tonic-clonic seizures, and about 20-40% of patients have absence seizures. These often happen when people first wake up in the morning. The exact cause is unknown, but a family history of epilepsy or gene mutations may sometimes be connected to the condition.

Symptoms of juvenile myoclonic epilepsy (Janz syndrome)

  • The hand or leg on one side occasionally jerks or makes a sudden movement

  • Limbs on one side of the body jerk when / just after waking up

  • Lose consciousness when sleep deprived

  • Lost consciousness when drinking alcohol or hungover

Questions your doctor may ask to check for juvenile myoclonic epilepsy (Janz syndrome)

  • Do your limbs jerk upon waking up?

  • Can lack of sleep cause loss of consciousness?

  • Do you black out when drinking alcohol or hungover?

Treatment for juvenile myoclonic epilepsy (Janz syndrome)

Juvenile myoclonic epilepsy (Janz syndrome) is typically well managed with medications for seizures. Most patients don't outgrow their seizures and will need to take medication for the rest of their lives. Getting enough sleep, avoiding alcohol, fatigue and anxiety can help lower the chances of seizures.

View the symptoms of Juvenile Myoclonic Epilepsy (Janz Syndrome)

  • Involuntary muscle jerks

Diseases related to Juvenile Myoclonic Epilepsy (Janz Syndrome)

References

  • Bittermann HJ, Steinhoff BJ. Die juvenile myoklonische Epilepsie (Janz-Syndrome). Ein gut bekanntes Epilepsiesyndrom? [Juvenile myoclonic epilepsy (Janz syndrome). A well-known epilepsy syndrome?]. Nervenarzt. 1998 Feb;69(2):127-30. German. doi: 10.1007/s001150050248. PMID: 9551456.

    https://pubmed.ncbi.nlm.nih.gov/9551456/#:~:text=Juvenile%20myoclonic%20epilepsy%20(JME)%20was,deprivation%2C%20alcohol%20consumption%20and%20flickering

  • Amrutkar CV, Riel-Romero RM. Juvenile Myoclonic Epilepsy. [Updated 2023 Feb 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537109/

    https://www.ncbi.nlm.nih.gov/books/NBK537109/#:~:text=Juvenile%20myoclonic%20epilepsy%20(JME)%2C,Lund%20in%201975%20as%20JME.

User testimonials

Reviewed By:

Unnati Patel, MD, MSc

Unnati Patel, MD, MSc (Primary Care Physician)

Dr Patel graduated from the Zhejiang University School of Medicine. She worked in clinical research at the University of Illinois in Chicago and University of Nevada in Las Vegas focused on culturally adapted health interventions for preventive medicine in the community setting. Received her Master's of Science in Global Health (concentration in Health Policy) from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. Unnati went on to complete her family medicine residency in Chicago, Illinois at Norwegian American Hospital. | | She is currently working as a primary care physician in the city of Chicago and completing her Master's of Business Administration at the Northwestern University Kellogg School of Management and Fellowship in Leadership in Value-Based Care.

Shohei Harase, MD

Shohei Harase, MD (Neurology)

Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.

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