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I have a bad memory
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Depressed
Unable to recall name
Difficulty rising from the sitting position
Change in personality
My body is jerking
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What is Progressive Subcortical Vascular Encephalopathy?
Progressive subcortical vascular encephalopathy (PSVE; also known as Binswanger disease) is a disorder in which patients develop worsening memory loss, mood changes, and gait imbalance due to cholesterol deposits and blockages in small blood vessels supplying the white matter and nerve cells (deep nuclei) under the surface of the brain. It is most common in elderly individuals with high blood pressure, active smoking, or history of stroke.
Typical Symptoms of Progressive Subcortical Vascular Encephalopathy
- Weakness or paralysis on one side of your body
- Seizure
- History of dementia
- Poor memory
- Writing difficulties
- Personality change
- Difficulty speaking clearly
- Patient unable to recall or speak his/her name and birthday
Diagnostic Questions for Progressive Subcortical Vascular Encephalopathy
Your doctor may ask these questions to check for this disease:
- Do you have weakness or paralysis on one side of your body?
- Have you experienced any seizures?
- Have you been diagnosed with dementia?
- Have you been experiencing memory problems recently?
- Have you been experiencing difficulties with writing?
Treatment of Progressive Subcortical Vascular Encephalopathy
There is no cure for this disorder. The treatment is mainly preventative and consists of controlling risk factors such as high blood pressure, diabetes, high cholesterol, or smoking. Antidepressant medications can help reduce depression associated with PSVE.
Reviewed By:
Benjamin Kummer, MD (Neurology)
Dr Kummer is Assistant Professor of Neurology at the Icahn School of Medicine at Mount Sinai (ISMMS), with joint appointment in Digital and Technology Partners (DTP) at the Mount Sinai Health System (MSHS) as Director of Clinical Informatics in Neurology. As a triple-board certified practicing stroke neurologist and informaticist, he has successfully improved clinical operations at the point of care by acting as a central liaison between clinical neurology faculty and DTP teams to implement targeted EHR configuration changes and workflows, as well as providing subject matter expertise on health information technology projects across MSHS. | Dr Kummer also has several years’ experience building and implementing several informatics tools, presenting scientific posters, and generating a body of peer-reviewed work in “clinical neuro-informatics” – i.e., the intersection of clinical neurology, digital health, and informatics – much of which is centered on digital/tele-health, artificial intelligence, and machine learning. He has spearheaded the Clinical Neuro-Informatics Center in the Department of Neurology at ISMMS, a new research institute that seeks to establish the field of clinical neuro-informatics and disseminate knowledge to the neurological community on the effects and benefits of clinical informatics tools at the point of care.
Shohei Harase, MD (Neurology)
Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.
Content updated on May 13, 2024
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui HC, Hachinski V. Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab. 2016 Jan;36(1):6-25. doi: 10.1038/jcbfm.2015.172. PMID: 26198175; PMCID: PMC4758552.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758552/Huisa BN, Rosenberg GA. Binswanger's disease: toward a diagnosis agreement and therapeutic approach. Expert Rev Neurother. 2014 Oct;14(10):1203-13. doi: 10.1586/14737175.2014.956726. Epub 2014 Sep 9. PMID: 25201523; PMCID: PMC4545265.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545265/Rosenberg GA. Inflammation and white matter damage in vascular cognitive impairment. Stroke. 2009 Mar;40(3 Suppl):S20-3. doi: 10.1161/STROKEAHA.108.533133. Epub 2008 Dec 8. PMID: 19064797; PMCID: PMC2811584.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811584/