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Redness of the skin
There are blisters
Spots in mouth
A pimple
Red spots on skin
Red bumps with white centers
Causing a blister
Not seeing your symptoms? No worries!
What is Sweet Syndrome?
A rare skin condition with sudden fever and painful rash on arms, legs, trunk, face, or neck. Most Sweet syndrome cases develop after upper respiratory or gastrointestinal infections or in people with certain cancers. Sometimes, it can be triggered by specific medications.
Typical Symptoms of Sweet Syndrome
- Ring-like rash
- Fever
- A lump or bump in the mouth
- Pus-filled blisters or bumps on the skin
- Skin problem on the chest, tummy or back
- Multiple areas of skin redness or red spots
- Swelling in the affected area
- Blisters on the skin
Diagnostic Questions for Sweet Syndrome
Your doctor may ask these questions to check for this disease:
- Do you have swollen red rings or circles on your hands, legs, or body?
- Do you have a fever?
- Have you noticed a lump or bump in your mouth?
- Do you have pus-filled blisters or bumps on your skin?
- Are there any skin problems on your stomach, chest, or back?
Treatment of Sweet Syndrome
Sweet syndrome treatment involves medications to reduce inflammation. If an underlying cause is found, it should also be treated to prevent recurrence.
Reviewed By:
Caroline M. Doan, DO (Internal Medicine)
Dr. Doan received a Bachelor of Science degree with honors from UCLA. Prior to obtaining her medical degree, she was involved in oncology clinical research at City of Hope, a National Cancer Institute-designated comprehensive cancer center in southern California. She attended medical school at Touro University California, and completed her residency in Internal Medicine at Oregon Health & Science University. She is certified by the American Board of Internal Medicine and holds an active medical license in several states. She currently works as a physician for Signify Health providing home-based health care.
Yukiko Ueda, MD (Dermatology)
Dr. Ueda graduated from the Niigata University School of Medicine and trained at the University of Tokyo Medical School. She is currently a clinical assistant professor at the Department of Dermatology, Jichi Medical University, and holds several posts in the dermatology departments at Kyoto Prefectural University of Medicine, Komagome Hospital, University of Tokyo, and the Medical Center of Japan Red Cross Society.
Content updated on Feb 19, 2025
Following the Medical Content Editorial Policy
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- Have a fever
- White or yellow sores on lips
- My body is hot
- Rash in mouth
- Recurrent fevers
- Periodic fever (>100.4°F / 38°C)
- Small rash in the mouth
- Fever then no fever then fever again
- Bulging patch of skin
- Canker sores
- Remittent fever of 102.2°F / 39°C
- Extremely high fever of 106.7°F / 41.5°C or higher
- Pus in the breast
- Fever of 100.4°F / 38°C or more for weeks
- Mouth is overly sensitive to cold or hot foot
See full list
Symptoms Related to Sweet Syndrome
Diseases Related to Sweet Syndrome
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Cohen PR, Talpaz M, Kurzrock R (1988). Malignancy-associated Sweet's syndrome: review of the world literature. Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
https://pubmed.ncbi.nlm.nih.gov/3058878/Cohen PR, Kurzrock R (2002). Sweet's syndrome: a review of current treatment options. American journal of clinical dermatology.
https://pubmed.ncbi.nlm.nih.gov/11893223/Joshi TP, Friske SK, Hsiou DA, Duvic M (2022). New Practical Aspects of Sweet Syndrome. American journal of clinical dermatology.
https://pubmed.ncbi.nlm.nih.gov/35157247/