von Willebrand Disease (vWD) Quiz
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Bleeding nose
Bruise easily
Red spots on the skin
Gums bleeding
Bleeding/bruising in the joints
Purplish rash
Not seeing your symptoms? No worries!
What is von Willebrand Disease (vWD)?
von Willebrand disease (vWD) is a common genetic blood disorder that impairs blood clotting leading to excess bleeding. In people with vWD, a protein called von Willebrand factor that is critical to blood clotting either does not function properly or is insufficient. As a result, people with vWD bleed more easily.
Typical Symptoms of von Willebrand Disease (vWD)
- History of excessive bleeding during delivery
- Blood in stool
- Family history of von Willebrand disease (VWD)
- Bleeding when brushing teeth
- Black, shiny stool
- Small red spots in the mouth
- Bleeding and bruising easily
- Red spots on the skin
Diagnostic Questions for von Willebrand Disease (vWD)
Your doctor may ask these questions to check for this disease:
- Did you have any heavy bleeding during delivery?
- Have you noticed any blood in your stool?
- Do you have a family history of von Willebrand disease (VWD)?
- Do you bleed when brushing your teeth?
- Have you had black, shiny stools?
Treatment of von Willebrand Disease (vWD)
While there is no cure, it can be managed and people can live normal lives. Mild cases of vWD may only have to be treated if injured or before surgical procedures where bleeding might be expected. Medications or injection of clotting factors may be prescribed to help the blood clot in more severe cases.
Reviewed By:
Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Dec 5, 2025
Following the Medical Content Editorial Policy
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- Blood in stool
- Bleeding gums when brushing
- Stools looks like strawberry jam
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- Stool looks like raspberry jelly
- Blood when brushing teeth but no pain
- Poop looks like strawberry jam
- Abdominal pain
- Poo looks like currant jelly
- Bleeding gums after brushing
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- Stool looks like jelly
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- My gums bleed when I brush my teeth
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See full list
Symptoms Related to von Willebrand Disease (vWD)
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FAQs
Q.
Scared of Brilinta? Why Your Blood Is Not Clotting & Medically Approved Next Steps
A.
If you are on Brilinta and notice your blood is not clotting, that is often the medication working as intended to prevent heart attacks and strokes, with mild bruising or longer bleeding being common, but red flag bleeding needs urgent care and you should never stop the drug without your doctor’s guidance. There are several factors to consider, including other medicines like aspirin, possible bleeding disorders such as vWD, and practical, medically approved next steps to reduce risk and decide when to seek help; see the complete answer below.
References:
* Schulz H, Schömig A, Neumann FJ, et al. Management of Bleeding Complications in Patients on Dual Antiplatelet Therapy with Aspirin and P2Y12 Inhibitors. J Clin Med. 2021;10(14):3152.
* Parikh C, Angiolillo DJ. Ticagrelor: A P2Y12 Inhibitor With Unique Clinical Features. Am J Cardiovasc Drugs. 2020;20(5):427-440.
* Zhang B, Cao Y, Xu T, et al. Ticagrelor Resistance: Current Knowledge and Management. Front Pharmacol. 2022;13:843187.
* Pavan S, Barco S, Di Marco F, et al. Reversal of ticagrelor-induced platelet inhibition in patients with acute bleeding or requiring urgent surgery. A systematic review. J Thromb Haemost. 2018;16(8):1501-1510.
* Capodanno D, Angiolillo DJ. Ticagrelor: a comprehensive review on pharmacology, clinical evidence and future directions. Eur Heart J Cardiovasc Pharmacother. 2016;2(1):3-15.
Q.
Unexplained Bleeding? Von Willebrand Disease: Why Your Blood Won’t Clot & Next Steps
A.
Unexplained bleeding can be caused by von Willebrand disease, the most common inherited bleeding disorder, where a low amount or poor function of von Willebrand factor slows clotting and leads to easy bruising, frequent nosebleeds, and heavy menstrual bleeding. There are several factors to consider, including acquired forms, the need for specialized and sometimes repeat blood tests, and treatments like desmopressin, von Willebrand factor concentrates, antifibrinolytics, and menstrual management, plus when to seek emergency care and how to plan for surgeries and dental work; see below for the complete guidance on next steps to discuss with your doctor.
References:
* **Blood. 2021 Apr 15;137(15):2013-2022.** Diagnosis, classification, and management of von Willebrand disease: an update. doi: 10.1182/blood.2020008892. PMID: 33657211.
* **Lancet. 2021 Jan 9;397(10269):186-200.** Von Willebrand disease. doi: 10.1016/S0140-6736(20)31238-6. PMID: 33422263.
* **Blood Adv. 2021 Mar 9;5(5):1378-1393.** ASH/ISTH/NHF/WFH 2021 guidelines for the management of von Willebrand disease. doi: 10.1182/bloodadvances.2020003223. PMID: 33703909.
* **Blood Rev. 2022 Nov;56:100985.** Von Willebrand disease: a concise review. doi: 10.1016/j.blre.2022.100985. PMID: 36179427.
* **J Clin Med. 2023 Apr 14;12(8):3017.** Von Willebrand Disease: Current Concepts and Future Directions. doi: 10.3390/jcm12083017. PMID: 37190048.
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL, Rick ME, Sadler JE, Weinstein M, Yawn BP (2007). von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). Haemophilia : the official journal of the World Federation of Hemophilia.
https://pubmed.ncbi.nlm.nih.gov/18315614/Sharma R, Flood VH (2018). Advances in the diagnosis and treatment of Von Willebrand disease. Blood.
https://pubmed.ncbi.nlm.nih.gov/29187375/Fogarty H, Doherty D, O'Donnell JS (2020). New developments in von Willebrand disease. British journal of haematology.
https://pubmed.ncbi.nlm.nih.gov/32394456/