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Fatigued
Malaise
Shortness of breath
Pale skin
Easy bruising
Extreme fatigue
Loss of appetite
Swollen lymph nodes
Bruises without injury
Constant vomiting and diarrhea
Sudden loss of appetite and feeling full
Fever
Not seeing your symptoms? No worries!
Leukemia is a cancer of the body's blood cell-forming tissues. Blood cells circulate in our bloodstream and are created and matured in the bone marrow and the lymphatic system. Leukemia involves white blood cells and lymphatic cells and has several types. The cancerous cells are produced in excess and do not function normally. Leukemias can be aggressive and cause symptoms or chronic and smolder for years.
Your doctor may ask these questions to check for this disease:
Treatment of leukemia is complex and variable; slow-growing leukemias may need monitoring and not require active treatment. Treatment options for aggressive leukemias include chemotherapy, radiation therapy, and stem-cell or bone marrow transplant.
Reviewed By:
Saqib Baig, MD, MS (Pulmonology, Critical Care, Internal Medicine)
Dr. Baig graduated from Army Medical College (NUST) Pakistan in 2007. He did his internal medicine training from Baltimore, Maryland, USA during the years 2009-2013. He joined the internal medicine faculty practice at Medical College of Wisconsin in USA for 2 years before pursuing advanced training. He completed his pulmonary disease and critical care medicine fellowship from Rutgers Robert Wood Johnson Medical School from 2015-2018. | | During his fellowship, Dr. Baig completed his master's in health care services management through Rutgers Business School. He currently serves as the medical director of respiratory therapy and pulmonary function lab and the clinical director of the COPD program at the Jane and Leonard Korman Respiratory Institute at Thomas Jefferson University. He holds the Assistant Professor of Medicine rank at Sidney Kimmel Medical College at Thomas Jefferson University. Dr. Baig's interests lie in respiratory physiology, airways disease, and data science.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Dec 6, 2024
Following the Medical Content Editorial Policy
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This questionnaire is customized to your situation and symptoms, including the following personal information:
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Male, 30s
I tend to be the kind of person that just ignores my symptoms or health until I'm on death's doorstep and am forced to go to the doctor, but after talking to Ubie, I realize I really do need to get to the doctor right away. Ubie aptly predicted that I might have leukemia. Leukemia and multiple myeloma run in my family, and I'm around the age my grandmother was when she was diagnosed with multiple myeloma. She passed away a few years after that, but I'm going to make sure I see a doctor ASAP; I don't want a family-repeat of the same thing.
(May 22, 2025)
Q.
Leukemia in Women 65+: 7 Symptoms Often Mistaken for Aging
A.
In women 65 and older, leukemia can resemble normal aging, showing up as unrelenting fatigue, shortness of breath with simple tasks, frequent infections or slow healing, easy bruising or bleeding, bone or joint pain, unexplained weight loss or loss of appetite, and night sweats or low-grade fevers. There are several factors to consider, including how long symptoms last, when to seek care, and what tests confirm a diagnosis, so see the complete guidance below for next steps, early evaluation benefits, and a symptom checker that can help you prepare for a doctor visit.
References:
* O'Donnell MR, Tallman MS. Diagnosis and Management of Acute Myeloid Leukemia in Older Adults. Semin Hematol. 2018 Jan;55(1):64-73. doi: 10.1053/j.seminhematol.2018.02.007. Epub 2018 Feb 21. PMID: 29555239.
* Al-Kali A, Litzow MR. The challenge of diagnosing acute myeloid leukemia in the elderly: A review of current diagnostic tools and considerations. Leuk Res. 2018 Sep;72:1-7. doi: 10.1016/j.leukres.2018.07.005. Epub 2018 Jul 9. PMID: 30032064.
* Klepin HD, Muss HB, Cohen HJ. Geriatric assessment in older patients with hematologic malignancies: a review. J Geriatr Oncol. 2013 Oct;4(4):307-16. doi: 10.1016/j.jgo.2013.06.002. Epub 2013 Jul 30. PMID: 24392095.
* Patel KV, Guralnik JM, Crainiceanu C, et al. Evaluation of Anemia in the Older Patient. JAMA. 2022 Mar 22;327(12):1171-1180. doi: 10.1001/jama.2022.2590. PMID: 35319727.
* Burnett AK, Russell N, Hills RK, et al. Acute myeloid leukemia in older patients: challenges and therapeutic opportunities. Cancer. 2011 May 1;117(9):1790-801. doi: 10.1002/cncr.25686. PMID: 21523719.
Q.
Early Leukemia Signs in Women: What Your Blood Work Means
A.
Early leukemia signs in women include persistent fatigue, frequent infections, easy bruising or bleeding, night sweats, shortness of breath, swollen lymph nodes, bone pain, and unintended weight loss; blood work clues often show up on a CBC as high or low white cells, anemia, low platelets, and immature cells on the differential or smear. There are several factors to consider; see below to understand what abnormal results do and do not mean, which red flags need prompt care, and how to plan next steps like repeating tests, using a symptom check, and talking with your doctor.
References:
* Bain BJ. The Complete Blood Count in the Diagnosis of Hematologic Malignancies. Clin Lab Med. 2015 Dec;35(4):877-90. doi: 10.1016/j.cll.2015.08.007. Epub 2015 Oct 13. PMID: 26613915.
* Khwaja J, Naeem A, Soni R. Clinical features and diagnostic challenges in myelodysplastic syndromes and acute myeloid leukemia. Blood Res. 2021 Apr;56(2):107-111. doi: 10.24875/BLTR.20000030. Epub 2021 Mar 18. PMID: 33741870; PMCID: PMC8130932.
* Zeidan AM, Stone RM. Initial Evaluation of Suspected Acute Leukemia. Hematol Oncol Clin North Am. 2020 Feb;34(1):1-14. doi: 10.1016/j.hoc.2019.09.001. Epub 2019 Nov 16. PMID: 31740203.
* Hallek M. Chronic Lymphocytic Leukemia: Diagnosis and Treatment Recommendations. Am J Hematol. 2017 Jan;92(1):94-105. doi: 10.1002/ajh.24584. Epub 2016 Nov 23. PMID: 27806540.
* Jäger M, Gisslinger H. Myeloproliferative Neoplasms: Diagnosis, Biology, and Treatment. J Clin Med. 2021 May 20;10(10):2220. doi: 10.3390/jcm10102220. PMID: 34070059; PMCID: PMC8157790.
Q.
Leukemia in Seniors: Modern Options for Late-Life Wellness
A.
In adults over 60, leukemia is treated with personalized plans that may include watchful waiting, targeted pills, immunotherapy, age‑adjusted chemotherapy, and selective reduced‑intensity transplants, with a strong focus on quality of life. Symptoms are often subtle and decisions depend on leukemia type, overall health, comorbidities, and personal goals; there are several factors to consider. See below for key details on signs, testing, side effect management, emotional support, and urgent reasons to call a doctor that could shape your next steps.
References:
* Kadia, T. M., Daver, N., Cortes, J. E., & Jabbour, E. J. (2023). Acute Myeloid Leukemia in the Older Patient: Novel Therapies and Evolving Concepts. Journal of Clinical Oncology, 41(34), 5220-5231.
* Shanafelt, T. D., Kay, N. E., & Wierda, W. G. (2022). Management of Chronic Lymphocytic Leukemia in Older Adults. Journal of Clinical Oncology, 40(23), 2631-2642.
* Wildes, T. M., O'Dwyer, K., & Kenzik, A. L. (2021). Geriatric Assessment in Older Adults With Hematologic Malignancies. Journal of Clinical Oncology, 39(16), 1779-1793.
* Fenaux, P., Savona, M. R., & Platzbecker, U. (2023). Management of Myelodysplastic Syndromes in Older Adults. Blood, 142(6), 509-520.
* Jabbour, E., Jain, N., O'Brien, S., Konopleva, M., & Kadia, T. M. (2023). Acute Lymphoblastic Leukemia in Older Adults. Hematology, 2023(1), 32-38.
Q.
Are there early symptoms of leukemia?
A.
Leukemia can have early symptoms, but they are often vague and easily mistaken for other common illnesses such as a cold or flu. This makes early diagnosis challenging, highlighting the importance of seeking medical attention if symptoms persist or worsen.
References:
Shephard EA, Neal RD, Rose PW, Walter FM, Hamilton W. Symptoms of adult chronic and acute leukaemia before diagnosis: large primary care case-control studies using electronic records. Br J Gen Pract. 2016 Mar;66(644):e182-8. doi: 10.3399/bjgp16X683989. PMID: 26917658; PMCID: PMC4758497.
Lan X, Wu J, Liao Z, Wu Y, Hu R. Prevalence of symptoms in children with acute lymphoblastic leukaemia: a systematic review and meta-analysis. BMC Cancer. 2023 Nov 15;23(1):1113. doi: 10.1186/s12885-023-11581-z. PMID: 37968600; PMCID: PMC10648628.
Chennamadhavuni A, Lyengar V, Mukkamalla SKR, Shimanovsky A. Leukemia. 2023 Jan 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32809325.
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Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1Juliusson G, Hough R. Leukemia. Prog Tumor Res. 2016;43:87-100. doi: 10.1159/000447076. Epub 2016 Sep 5. PMID: 27595359.
https://www.karger.com/Article/Abstract/447076Devine SM, Larson RA. Acute leukemia in adults: recent developments in diagnosis and treatment. CA Cancer J Clin. 1994 Nov-Dec;44(6):326-52. doi: 10.3322/canjclin.44.6.326. PMID: 7953914.
https://onlinelibrary.wiley.com/resolve/doi?DOI=10.3322/canjclin.44.6.326Peters JM, Ansari MQ. Multiparameter flow cytometry in the diagnosis and management of acute leukemia. Arch Pathol Lab Med. 2011 Jan;135(1):44-54. doi: 10.5858/2010-0387-RAR.1. PMID: 21204710.
https://meridian.allenpress.com/aplm/article/135/1/44/461150/Multiparameter-Flow-Cytometry-in-the-Diagnosis-andBrunning RD. Classification of acute leukemias. Semin Diagn Pathol. 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428.
https://www.sciencedirect.com/science/article/abs/pii/S0740257003000315?via%3Dihub