Watery Diarrhea, Hypokalemia, and Achlorhydria (WDHA) Syndrome Quiz

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Reviewed By:

Scott Nass, MD, MPA, FAAFP, AAHIVS

Scott Nass, MD, MPA, FAAFP, AAHIVS (Primary Care Physician)

Dr. Nass received dual medical degrees from the David Geffen School of Medicine at UCLA and Charles R. Drew University in Medicine and Science. He completed Family Medicine residency at Ventura County Medical Center with subsequent fellowships at Ventura, University of North Carolina-Chapel Hill, George Washington University, and University of California-Irvine. He holds faculty appointments at Keck School of Medicine of USC, Loma Linda University School of Medicine, and Western University of Health Sciences.

Yoshinori Abe, MD

Yoshinori Abe, MD (Internal medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

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Learn more about Watery Diarrhea, Hypokalemia, and Achlorhydria (WDHA) Syndrome

Content updated on Jan 19, 2024

What is watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome?

WDHA syndrome, which stands for watery diarrhea, hypokalemia, and achlorhydria, is a rare condition caused by an excess of vasoactive intestinal polypeptide (VIP) secreted by certain tumors. VIP is both a neuromodulator and a neurotransmitter that dilates blood vessels, regulates smooth muscle activity, cell secretion, and blood flow in the gastrointestinal tract.

Symptoms of watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome

  • Weakness in arms or legs

  • Fatigue

  • Recent weight loss

  • Feel the heart is pounding

  • Diarrhea

  • Dry Mouth

  • Facial flushing

  • Nausea or vomiting

Questions your doctor may ask to check for watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome

  • Do your arms or legs feel weak?

  • Do you feel you fatigued?

  • Did you lose weight recently?

  • Is your heart pounding?

  • Do you have loose stools or diarrhea?

Treatment for watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome

Treatment involves correcting blood volume, electrolytes, and metabolic abnormalities, as well as using medication to decrease gastrointestinal secretion and increase absorption. Surgical removal of the tumor is also necessary.

View the symptoms of Watery Diarrhea, Hypokalemia, and Achlorhydria (WDHA) Syndrome

Diseases related to Watery Diarrhea, Hypokalemia, and Achlorhydria (WDHA) Syndrome

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Reviewed By:

Scott Nass, MD, MPA, FAAFP, AAHIVS

Scott Nass, MD, MPA, FAAFP, AAHIVS (Primary Care Physician)

Dr. Nass received dual medical degrees from the David Geffen School of Medicine at UCLA and Charles R. Drew University in Medicine and Science. He completed Family Medicine residency at Ventura County Medical Center with subsequent fellowships at Ventura, University of North Carolina-Chapel Hill, George Washington University, and University of California-Irvine. He holds faculty appointments at Keck School of Medicine of USC, Loma Linda University School of Medicine, and Western University of Health Sciences.

Yoshinori Abe, MD

Yoshinori Abe, MD (Internal medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

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