Watery Diarrhea, Hypokalemia, and Achlorhydria (WDHA) Syndrome Quiz
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Diarrhea
Fatigued
Loss of appetite
Flushed face
Lost weight recently
Heart palpitations
Weak
Not seeing your symptoms? No worries!
What is Watery Diarrhea, Hypokalemia, and Achlorhydria (WDHA) Syndrome?
WDHA syndrome, which stands for watery diarrhea, hypokalemia, and achlorhydria, is a rare condition caused by an excess of vasoactive intestinal polypeptide (VIP) secreted by certain tumors. VIP is both a neuromodulator and a neurotransmitter that dilates blood vessels, regulates smooth muscle activity, cell secretion, and blood flow in the gastrointestinal tract.
Typical Symptoms of Watery Diarrhea, Hypokalemia, and Achlorhydria (WDHA) Syndrome
- Weakness in your arms or legs
- Dry mouth
- Recent weight loss
- Episode of low blood pressure
- Fatigue or low energy
- Facial flushing
- Heart pounding
- Diarrhea or loose stools
Diagnostic Questions for Watery Diarrhea, Hypokalemia, and Achlorhydria (WDHA) Syndrome
Your doctor may ask these questions to check for this disease:
- Do you have weakness in your arms or legs?
- Are you experiencing a dry mouth?
- Have you experienced any recent weight loss?
- Is your blood pressure lower than usual?
- Are you experiencing fatigue or low energy?
Treatment of Watery Diarrhea, Hypokalemia, and Achlorhydria (WDHA) Syndrome
Treatment involves correcting blood volume, electrolytes, and metabolic abnormalities, as well as using medication to decrease gastrointestinal secretion and increase absorption. Surgical removal of the tumor is also necessary.
Reviewed By:
Scott Nass, MD, MPA, FAAFP, AAHIVS (Primary Care)
Dr. Nass received dual medical degrees from the David Geffen School of Medicine at UCLA and Charles R. Drew University in Medicine and Science. He completed Family Medicine residency at Ventura County Medical Center with subsequent fellowships at Ventura, University of North Carolina-Chapel Hill, George Washington University, and University of California-Irvine. He holds faculty appointments at Keck School of Medicine of USC, Loma Linda University School of Medicine, and Western University of Health Sciences.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Feb 13, 2025
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Henry, K. (2019). Paraneoplastic syndromes: Definitions, classification, pathophysiology and principles of treatment. Seminars in Diagnostic Pathology.
https://www.sciencedirect.com/science/article/pii/S0740257019300097Guilmette, J., & Nosé, V. (2019). Paraneoplastic syndromes and other systemic disorders associated with neuroendocrine neoplasms. Seminars in Diagnostic Pathology.
https://www.sciencedirect.com/science/article/pii/S0740257019300206Granberg, D. (2015). Biochemical testing in patients with neuroendocrine tumors. Neuroendocrine Tumors: A Multidisciplinary Approach.
https://karger.com/Article/PDF/381981