Watery Diarrhea, Hypokalemia, and Achlorhydria (WDHA) Syndrome Quiz

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Scott Nass, MD, MPA, FAAFP, AAHIVS (GP / Family doctor)

Dr. Nass received dual medical degrees from the David Geffen School of Medicine at UCLA and Charles R. Drew University in Medicine and Science. He completed Family Medicine residency at Ventura County Medical Center with subsequent fellowships at Ventura, University of North Carolina-Chapel Hill, George Washington University, and University of California-Irvine. He holds faculty appointments at Keck School of Medicine of USC, Loma Linda University School of Medicine, and Western University of Health Sciences.

Yoshinori Abe, MD (Internal medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

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Learn more about Watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome

Content updated on Sep 20, 2022

What is watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome?

WDHA (watery diarrhea, hypokalemia, and achlorhydria) syndrome is an unusual condition caused by excess vasoactive intestinal polypeptide (VIP) secreted by certain tumors. VIP is a neuromodulator and neurotransmitter. It dilates blood vessels, regulates smooth muscle activity, cell secretion and blood flow in the gastrointestinal tract.

Symptoms of watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome

Fatigue
Diarrhea
Recent weight loss
Loss of appetite
Weakness in arms or legs
Facial flushing
Feel the heart is pounding

Questions your doctor may ask to check for watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome

Your doctor may ask these questions to diagnose watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome

Do you feel fatigued?
Do you have loose stools or diarrhea?
Have you lost weight recently?
Do you have less or no appetite, therefore eat less food?
Do you feel any weakness in your arms or legs?

Treatment for watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome

Treatment includes correction of blood volume, electrolytes, and metabolic abnormalities, and medication to decrease gastrointestinal secretion and increase absorption. Surgical removal of the tumor is also required.