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Published on: 7/22/2025

What other diseases have symptoms similar to chronic Lyme disease?

Chronic Lyme disease symptoms can be similar to those of chronic fatigue syndrome, fibromyalgia, and certain autoimmune diseases, making it challenging to diagnose.

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Explanation

Chronic Lyme disease, also known as post-treatment Lyme disease syndrome, shares symptoms with several other conditions, which can make it hard to tell them apart. Chronic Fatigue Syndrome (CFS) is one such condition. Both chronic Lyme disease and CFS can cause extreme tiredness, sleep problems, and trouble concentrating.

Another condition with similar symptoms is Fibromyalgia. People with fibromyalgia often experience widespread pain, tiredness, and sleep disturbances, which are also seen in chronic Lyme disease.

Additionally, some autoimmune diseases might have overlapping symptoms. These diseases can cause joint pain, fatigue, and other systemic symptoms that can resemble those of chronic Lyme disease.

Because these conditions share symptoms, doctors must consider these possibilities when diagnosing someone with symptoms of chronic Lyme disease. It is important for people experiencing such symptoms to consult healthcare professionals for proper evaluation and diagnosis.

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