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Published on: 7/15/2026
Inner knee pain while running is often caused by runner's knee (patellofemoral pain syndrome) or stress on the inner knee tissues from overstriding. Runner's knee typically produces a dull ache around or behind the kneecap, especially when bending the knee, while overstriding places excess strain on the medial (inner) structures of the knee, leading to localized pain along the inside of the joint. Other possible causes include a medial meniscus injury, MCL strain, or pes anserine bursitis.
Because inner knee pain can stem from several different conditions—each requiring a different approach to recovery—identifying the likely cause early is key to preventing it from getting worse. A free, instant, online symptom check can help you pinpoint what's most likely going on based on your specific symptoms and guide you toward the right next steps, whether that's rest and form adjustments or seeing a professional.
Reviewed for medical accuracy: 07/14/2026
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Submit your own QuestionWhen running, the inner side of your knee can hurt for several reasons. One common cause is patellofemoral pain syndrome, also known as runner's knee, which happens when the kneecap does not move smoothly over the thigh bone. This can show up as pain around the front or inner part of the knee. Another possibility is that your inner knee tissues, such as tendons or ligaments, are being strained. This might happen when you overstride—landing with your foot too far in front of your body—which can lead to a condition sometimes called medial knee desmopathy. These conditions can be worsened by overuse, not warming up properly, weak muscles, or wearing shoes that don't give enough support. To help prevent or reduce pain, try working on your running technique, strengthening your leg muscles, and using supportive shoes. Remember, if your pain gets worse or does not go away, it is important to check your symptoms to better understand what might be causing your knee discomfort.
(References)
Johar SK. Medial knee pain in a runner: a case report. Sports Health. 2010 Jul;2(4):318-20. doi: 10.1177/1941738110365137. PMID: 21416059; PMCID: PMC3445093.
Fisher R, Nye NS, Soles J, Waldhelm A, Gottfredson R. Overstride-Induced Medial Knee Desmopathy: An Exploration Case Series. J Athl Train. 2020 Dec 1;55(12):1255-1261. doi: 10.4085/1062-6050-0099.20. PMID: 33196795; PMCID: PMC7740061.
InformedHealth.org. [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Overview: Patellofemoral pain syndrome (runner's knee) [Updated 2024 Jan 30]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK561507/
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