What Are the Side Effects of Izervay?

Family Medicine, Primary Care Roots Community Health Center, Hippo Education, Kameda Medical Center

Supervised by Kenji Taylor, MD

Izervay (avacincaptad pegol) can sometimes cause eye pain, redness, or inflammation after an injection, and these side effects are usually temporary. It is important to follow your doctor's care and report any unusual eye symptoms.

Explanation

Izervay is a treatment given by injection into the eye to help slow the vision loss seen in geographic atrophy. In research studies, some people experienced side effects after their injection. The most common side effects were eye pain and a red or irritated eye. Some people also had mild inflammation inside the eye or a little bleeding near the injection spot. These reactions are similar to what some may feel after other eye injections. For many, these side effects were short-lived and got better on their own or with extra care from their doctor. It is important to remember that while this treatment can help protect your vision, any eye treatment might come with some discomfort. If you notice worsening pain, significant redness, or changes in vision, you should contact your doctor right away. Your doctor will check your eyes to make sure everything is healing as it should and may suggest treatments like drops or medicines to help manage these side effects.

(References)

Khanani AM, Patel SS, Staurenghi G, Tadayoni R, Danzig CJ, Eichenbaum DA, Hsu J, Wykoff CC, Heier JS, Lally DR, Monés J, Nielsen JS, Sheth VS, Kaiser PK, Clark J, Zhu L, Patel H, Tang J, Desai D, Jaffe GJ; GATHER2 trial investigators. Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial. Lancet. 2023 Oct 21;402(10411):1449-1458. doi: 10.1016/S0140-6736(23)01583-0. Epub 2023 Sep 8. PMID: 37696275.
Shakeel L, Khan A, Akilimali A. "Izervay (avacincaptad pegol): paving the way for vision preservation in geographic atrophy". Ann Med Surg (Lond). 2024 Apr 3;86(5):2413-2416. doi: 10.1097/MS9.0000000000002021. PMID: 38694318; PMCID: PMC11060312.

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