Naproxen Over 65: Protecting Your Stomach & Kidneys

Naproxen Over 65: Protecting Your Stomach & Kidneys

Naproxen is a common pain reliever used for arthritis, back pain, gout flares, headaches, and other inflammatory conditions. It belongs to a group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). For many adults, naproxen can be effective and convenient. However, if you are over 65, your stomach and kidneys need extra protection when using this medication.

This guide explains how naproxen works, why age matters, and what practical steps can help reduce risks—without causing unnecessary worry. It also highlights when it's important to speak to a doctor.

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How Naproxen Works

Naproxen reduces pain and inflammation by blocking enzymes (COX-1 and COX-2) that produce prostaglandins. Prostaglandins play a role in:

• Pain and swelling
• Protecting the stomach lining
• Supporting blood flow to the kidneys

When prostaglandins are reduced, pain improves—but protective effects in the stomach and kidneys may also decrease. This is why side effects are more likely with age or long-term use.

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Why Age Over 65 Matters

As we age, the body processes medications differently. According to widely accepted medical guidance (including FDA labeling and geriatric prescribing standards), adults over 65 are more sensitive to NSAIDs like naproxen because:

• The stomach lining becomes thinner and more fragile
• Kidney function naturally declines with age
• Many older adults take multiple medications that can interact
• Recovery from side effects may take longer

This does not mean naproxen is off-limits, but it does mean it should be used thoughtfully.

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Stomach Risks of Naproxen in Older Adults

What Can Happen

Naproxen can irritate the stomach and intestines. In adults over 65, this may lead to:

• Stomach pain or indigestion
• Heartburn or nausea
• Stomach or intestinal ulcers
• Bleeding in the digestive tract

Sometimes bleeding can occur without obvious pain, making it harder to detect early.

Higher Risk If You:

• Have a history of ulcers or stomach bleeding
• Take blood thinners, aspirin, or steroids
• Drink alcohol regularly
• Use naproxen daily or at high doses

Warning Signs to Watch For

• Black or tarry stools
• Vomiting blood or material that looks like coffee grounds
• Ongoing stomach pain or weakness

These symptoms can be serious. If they appear, seek medical care right away.

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Kidney Risks of Naproxen After 65

Why Kidneys Are Affected

The kidneys rely on prostaglandins to maintain healthy blood flow. Naproxen can reduce this flow, which may:

• Lower kidney function temporarily or permanently
• Cause fluid retention and swelling
• Raise blood pressure

Higher Risk If You:

• Have chronic kidney disease
• Have heart failure or liver disease
• Are dehydrated
• Take diuretics ("water pills") or blood pressure medications like ACE inhibitors

Possible Kidney-Related Symptoms

• Swelling in ankles, feet, or legs
• Reduced urine output
• Sudden weight gain from fluid
• Fatigue or confusion

If you're experiencing persistent discomfort like Leg Cramps, which can sometimes be related to fluid imbalances or medication side effects, a free AI-powered symptom checker can help you organize your concerns before your next doctor's visit.

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Safe Use Tips for Naproxen Over 65

Many adults over 65 use naproxen safely by following a few key principles.

Use the Lowest Effective Dose

• Start with the smallest dose that relieves pain
• Avoid increasing the dose without medical advice
• Do not combine with other NSAIDs

Limit Duration

• Short-term use is generally safer than long-term use
• Chronic daily use should be monitored by a doctor

Take With Food

• Taking naproxen with meals can reduce stomach irritation
• Avoid taking it on an empty stomach

Stay Hydrated

• Drink adequate fluids unless your doctor advises otherwise
• Dehydration increases kidney stress

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Medications and Substances to Be Careful With

Naproxen can interact with other common medications. Tell your doctor if you take:

• Blood thinners (such as warfarin)
• Aspirin for heart protection
• Steroids like prednisone
• Certain blood pressure medicines
• Diuretics
• Antidepressants that affect bleeding risk

Avoid regular alcohol use while taking naproxen, as this increases the risk of stomach bleeding.

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Monitoring: A Smart Safety Step

If naproxen is part of your regular routine, your doctor may recommend:

• Periodic kidney function blood tests
• Blood pressure monitoring
• Checking for anemia (which can signal hidden bleeding)

These checks help catch problems early, often before symptoms appear.

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Alternatives to Naproxen

Depending on your health history, your doctor may suggest other pain strategies, such as:

• Acetaminophen (safer for the stomach and kidneys when used correctly)
• Topical anti-inflammatory gels or creams
• Physical therapy or guided exercise
• Heat or cold therapy
• Short courses of naproxen with stomach-protective medication

Never switch or stop medications without professional guidance.

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When Naproxen May Not Be Appropriate

In some situations, naproxen may not be the right choice, especially without close supervision. This includes:

• Active stomach ulcers
• Advanced kidney disease
• Uncontrolled heart failure
• Recent gastrointestinal bleeding

In these cases, a doctor can help weigh risks and benefits and suggest safer alternatives.

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When to Speak to a Doctor Right Away

You should speak to a doctor immediately or seek urgent care if you experience:

• Severe stomach pain or bleeding
• Sudden swelling or shortness of breath
• Very low urine output
• Confusion or extreme fatigue
• Chest pain or stroke-like symptoms

These can be life-threatening and require prompt medical attention.

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The Bottom Line

Naproxen can be an effective pain reliever for adults over 65, but it deserves respect. The stomach and kidneys are more vulnerable with age, and risks increase with higher doses, longer use, and certain health conditions.

Key takeaways:

• Use the lowest effective dose for the shortest time
• Protect your stomach and kidneys with smart habits
• Watch for warning signs, even subtle ones
• Review all medications with your healthcare provider

If pain, swelling, or muscle cramping is affecting your quality of life, organizing your symptoms can help. You may find it useful to try a free, online symptom check for Leg Cramps and then discuss the results with a clinician.

Above all, speak to a doctor about ongoing pain, medication concerns, or anything that feels serious or potentially life-threatening. Thoughtful use and good communication are the best ways to stay safe while getting the relief you need.