Published on: 5/6/2025
Pain behind the knee and in the calf after sitting can be caused by a fluid-filled bump known as a Baker's cyst, muscle or vein discomfort from prolonged sitting, or less commonly, inflammation of a small bursa near the knee called Pes Anserine bursitis.
Sometimes, when you sit for a long time, fluid can build up behind your knee and create a Baker's cyst. This bump may hurt, especially when you start moving again. Prolonged sitting can also change how blood flows in your leg muscles and calves, which may lead to discomfort. Studies have shown that sitting too long might affect calf muscle structure and cause pain when you move. Another possible cause is Pes Anserine bursitis, where a small fluid-filled sac near the inside of your knee gets swollen and tender. In all these situations, pain might start after being still for a while and then make you feel worse when you stand or walk. Less commonly, pain after a period of prolonged immobility (long distance flight) could be a sign of a blood clot in the leg. If the pain grows or you notice swelling or redness, it is important to speak with a healthcare provider for more guidance and to rule out any serious issues.
(References)
Okino K, Aoki M, Yamane M, Kataoka Y, Nitta A, Kohmura C. Prolonged Sitting Causes Leg Discomfort in Middle Aged Adults: Evaluation of Shear Wave Velocity, Calf Circumference, and Discomfort Questionaries. J Clin Med. 2022 Jul 12;11(14):4024. doi: 10.3390/jcm11144024. PMID: 35887787; PMCID: PMC9320137.
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