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Published on: 11/26/2025
Yes, sleep medications can lose effectiveness over time because the body can get used to them.
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Submit your own QuestionSleep medications, like antihistamines and benzodiazepines, can become less effective over time. This happens because the body can develop a tolerance, meaning you might need more of the medication to get the same effect.
Antihistamines:
Benzodiazepines:
Non-benzodiazepines:
If you are having trouble with sleep medications not working well, it is important to talk to a doctor. They can help find a solution that is safe and works for you. For mental health support, visit 988lifeline.org.
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