Currently on Antidepressants
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Try one of these related symptoms.
Insomnia
Nausea
Dry mouth
Weight gain
Stomach ache
Sexual dysfunction
Feeling nauseous
Unexplained weight loss
Rapid weight loss
Low libido
Thirsty all the time
Feeling nauseous all the time but not throwing up
About the Symptom
Taking a medication.
Possible Causes
Generally, Currently on antidepressants can be related to:
- Bipolar Disorder
A disorder marked by extreme and persistent shifts in mood that last for weeks to months, from periods of sustained depression to periods of elevated mood and euphoria. The precise cause is unclear, but genetic and environmental factors contribute.
- Osteoporosis
Osteoporosis is a disease that makes your bones weak and brittle. As result, the bones become more prone to break even with minor trauma or stress that would normally not result in a break. It may be caused due to long-term low calcium intake, estrogen deficiencies in women, and an inactive lifestyle.
Doctor's Diagnostic Questions
Your doctor may ask these questions to check for this symptom:
- Are you on any antidepressants?
Reviewed By:
Charles Carlson, DO, MS (Psychiatry)
Dr. Carlson graduated from Touro University in Nevada with a degree in osteopathic medicine. He then trained as a resident in Psychiatry at Case Western Reserve University/University Hospitals where he was also a chief resident and completed a fellowship in Public and Community Psychiatry. After training, he started practicing in | Addiction Psychiatry at the U.S. Department of Veterans Affairs where he also teaches Psychiatry residents.
Yu Shirai, MD (Psychiatry)
Dr. Shirai works at the Yotsuya Yui Clinic for mental health treatment for English and Portuguese-speaking patients. He treats a wide range of patients from neurodevelopmental disorders to dementia in children and participates in knowledge sharing through the Diversity Clinic.
Content updated on Jan 29, 2025
Following the Medical Content Editorial Policy
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This questionnaire is customized to your situation and symptoms, including the following personal information:
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FAQs
Q.
Fluoxetine for Women 30-45: Symptoms & Essential Next Steps
A.
Fluoxetine can help women 30 to 45 manage depression, anxiety, and PMDD by improving mood, sleep, energy, and focus, but there are several factors to consider. Benefits usually take 2 to 6 weeks, common side effects include nausea, insomnia, and sexual changes, and red flags like suicidal thoughts, mania, allergic reactions, seizures, or sudden confusion need urgent care; see below for details that could change your next steps. Do not stop suddenly; instead track symptoms, talk with your prescriber about dose and timing, combine medication with therapy and healthy habits, schedule regular follow ups, and seek prompt advice if there is no improvement by 6 to 8 weeks or if you are pregnant or planning pregnancy; complete next steps are outlined below.
References:
* Clayton, A. H., & O'Leary, R. L. (2018). Treatment of Major Depressive Disorder in Women. *Current Psychiatry Reports*, *20*(12), 108.
* Marjoribanks, J., & O'Brien, P. M. (2019). Selective serotonin reuptake inhibitors for premenstrual syndrome. *Cochrane Database of Systematic Reviews*, (12), CD001396.
* Montejo-González, A. L., Llorca, G., Izquierdo, J. A., Ledesma, A., Bousoño, M., Calcedo, A., ... & Montejo, A. L. (2015). SSRI-induced sexual dysfunction: a review of the literature and recommendations for management. *Journal of Clinical Psychiatry*, *76*(Suppl 2), 16-24.
* Klieger, L. M., & Kanes, S. J. (2020). Psychiatric Medication Use During Pregnancy: A Review. *Primary Care Companion for CNS Disorders*, *22*(4), 19r02582.
* Fava, M., & Kendig, R. (2020). Fluoxetine: Efficacy, safety, and current role in clinical practice. *CNS Spectrums*, *25*(6), 724-738.
Q.
Lexapro for Women 30-45: Symptom Guide & Critical Next Steps
A.
For women 30 to 45, Lexapro can help relieve depression and anxiety with benefits building over 4 to 8 weeks, but watch for common effects like sleep or sexual changes, possible weight gain, and emotional blunting, and know urgent red flags that require immediate care such as new suicidal thoughts or signs of serotonin syndrome. There are several factors to consider, including perimenopausal hormones, fertility or pregnancy plans, not stopping suddenly, and next steps like tracking symptoms, early follow-ups, and adding therapy and lifestyle support; see the complete guidance below to choose the safest, most effective plan.
References:
* Shah N, et al. Escitalopram in the treatment of women with major depressive disorder: a systematic review. Expert Opin Pharmacother. 2011 Sep;12(13):2059-69. doi: 10.1517/14656566.2011.602554. PMID: 21919782.
* Yonkers KA, et al. Antidepressant Use in Reproductive-Aged Women: Clinical Considerations. Psychiatr Clin North Am. 2017 Mar;40(1):15-32. doi: 10.1016/j.psc.2016.10.002. PMID: 28153177.
* Keltz D, et al. Sexual Dysfunction in Women Treated With SSRIs: A Review of the Literature. J Clin Psychiatry. 2021 Mar 9;82(2):null. doi: 10.4088/JCP.19r13054. PMID: 33705001.
* Patel S, et al. Weight gain associated with escitalopram: a review of current evidence and clinical considerations. Expert Opin Drug Saf. 2021 Jan;20(1):79-90. doi: 10.1080/14740338.2021.1852934. PMID: 33249969.
* Bunevicius A, et al. Pharmacologic Treatment of Premenstrual Dysphoric Disorder: A Review. J Clin Psychiatry. 2020 Jan 28;81(1):null. doi: 10.4088/JCP.19r12918. PMID: 31995166.
Q.
Prozac for Women 30-45: Symptom Guide & Essential Next Steps
A.
Prozac can help women 30 to 45 with depression, anxiety, PMDD, and some perimenopausal mood changes; benefits usually build over 4 to 6 weeks, common side effects often settle, and urgent red flags like new suicidal thoughts, severe agitation, fever with confusion, or rapid heart rate need immediate care. There are several factors to consider. See the complete guidance below for how hormones, pregnancy and breastfeeding plans, partial response, sexual side effects, and lifestyle changes can affect your plan, plus clear next steps on tracking symptoms, discussing options with your clinician, and when to seek urgent help.
References:
* Epperson CN, Wager TD, et al. Fluoxetine in the treatment of major depression during perimenopause: A randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2011 Nov;72(11):1455-61. doi: 10.4088/JCP.10m06616whi. PMID: 22112448; PMCID: PMC3251786.
* Clayton AH, Croft HA, Schmaling KB, et al. Sexual dysfunction in women taking antidepressants: a prospective study. J Sex Marital Ther. 2002 May-Jun;28(3):263-7. doi: 10.1080/009262302760331776. PMID: 12056079.
* Steiner M, Korzekwa M, Peer M, et al. Fluoxetine in the treatment of premenstrual dysphoric disorder. A double-blind, placebo-controlled, crossover study. J Clin Psychopharmacol. 1995 Aug;15(4):S22-9. doi: 10.1097/00004714-199508001-00004. PMID: 7594165.
* Pearlstein TB, et al. Management of depression in women across the lifespan: a narrative review. Maturitas. 2020 Jul;137:55-65. doi: 10.1016/j.maturitas.2020.04.015. Epub 2020 Apr 29. PMID: 32473523.
* Jalily-Baleh L, et al. Antidepressant adherence in women: a systematic review. J Womens Health (Larchmt). 2014 Mar;23(3):195-207. doi: 10.1089/jwh.2013.4357. Epub 2014 Jan 22. PMID: 24450371.
Q.
Venlafaxine for Women 30-45: Side Effects & What to Do Next
A.
For women 30 to 45, venlafaxine can be effective for depression and anxiety, but side effects like nausea, sleep changes, sweating, sexual problems, headaches or dizziness, weight changes, and higher blood pressure can occur, and rare issues like serotonin syndrome or severe mood shifts require urgent care. There are several factors to consider; see below to understand more. Next steps include monitoring blood pressure, not stopping the medication abruptly due to withdrawal, seeking immediate help for red flags such as fever, confusion, chest pain, or suicidal thoughts, and discussing pregnancy or perimenopause with your clinician; complete details and what to do in each situation are outlined below.
References:
* Mei, B., Lin, Y., Wan, D., Li, X., Wu, X., & Liu, Z. (2020). Side effects of venlafaxine in the treatment of major depressive disorder: a systematic review and meta-analysis. European Journal of Clinical Pharmacology, 76(2), 163–175. PMID: 31734614.
* Clayton, A. H., & El Haddad, H. (2016). Management of antidepressant-induced sexual dysfunction. Dialogues in Clinical Neuroscience, 18(2), 159–168. PMID: 27489508.
* Pirotta, A. F., & Manion, J. A. (2022). Antidepressant withdrawal syndrome: a narrative review for the generalist. Australian Journal of General Practice, 51(3), 164–168. PMID: 35246700.
* Althoff, T., Stübner, S., Aicher, K., & Pfeiffer, T. (2022). Antidepressant use in women of reproductive age: A systematic review of the adverse effects. Journal of Psychiatric Research, 151, 10–22. PMID: 35303531.
* Thase, M. E. (2014). The Role of Venlafaxine Extended-Release (XR) in the Treatment of Depression and Other Psychiatric Disorders. Dialogues in Clinical Neuroscience, 16(4), 499–513. PMID: 25567906.
Q.
Cymbalta Side Effects in Seniors: What Women Over 65 Must Know
A.
Cymbalta can help women over 65 with depression, anxiety, and chronic pain, but older bodies process it differently, making side effects like nausea, dry mouth, constipation, fatigue, and dizziness more likely, and increasing risks such as falls, blood pressure or heart rate changes, and rare low sodium with confusion or unsteadiness. There are several factors to consider, including interactions with other medicines, mood, sleep, digestive, or urinary changes, and the need to taper rather than stop suddenly; know when to seek urgent care for fainting, severe confusion, chest pain, shortness of breath, allergic reactions, or worsening depression. See the complete guidance below for what to monitor, safer dosing, and when Cymbalta may not be the best choice.
References:
* Liu Y, et al. Safety and tolerability of duloxetine for the treatment of major depressive disorder in elderly patients: a meta-analysis. Clin Interv Aging. 2014 Apr 2;9:603-9. doi: 10.2147/CIA.S57908. PMID: 24707255; PMCID: PMC3979856.
* Tang Q, et al. Duloxetine for the treatment of major depressive disorder in elderly patients: a systematic review and meta-analysis. Exp Ther Med. 2015 Jul;10(1):163-169. doi: 10.3892/etm.2015.2505. Epub 2015 Apr 22. PMID: 26056586; PMCID: PMC4478140.
* Zubenko GS. Pharmacokinetic and Pharmacodynamic Considerations in the Treatment of Older Adults with Major Depressive Disorder. Drugs Aging. 2018 Jun;35(6):487-505. doi: 10.1007/s40266-020-01121-8. PMID: 29775338.
* Kishi T, et al. Safety and Tolerability of Duloxetine in Older Adults with Major Depressive Disorder and Comorbid Pain. Prim Care Companion CNS Disord. 2018 Mar 1;20(2):17m02279. doi: 10.4088/PCC.17m02279. PMID: 29505963.
* Maneeton B, et al. Effectiveness and safety of duloxetine in a broad population of patients with major depressive disorder: a review of the current evidence. J Affect Disord. 2014 Aug;165:1-9. doi: 10.1016/j.jad.2014.04.053. Epub 2014 May 6. PMID: 24857410.
Q.
Trazodone Side Effects in Seniors: What Women 65+ Must Know
A.
For women 65 and older, trazodone can help sleep and mood but aging raises the risk of side effects like morning sedation and dizziness, falls from low blood pressure, heart rhythm changes, cognitive fog, and medication interactions, so doses should start low and be monitored closely. There are several factors to consider, and red flags like fainting, chest pain or palpitations, sudden confusion, severe dizziness, or symptoms of serotonin syndrome need immediate care. See below for complete details and practical next steps to discuss with your clinician.
References:
* Jager, P., van de Beek, D., & van der Velde, N. (2018). Trazodone for Insomnia: A Systematic Review. *Drugs & Aging*, *35*(12), 1039-1051.
* Rissman, M., Kim, J. H., & O'Brien, S. (2020). Trazodone for sleep in older adults with dementia: a review. *Current Psychiatry Reports*, *22*(8), 40.
* Huang, A. R., Hwang, J., Mallet, L., Mamdani, M., & Rochon, P. A. (2020). Risk of serious adverse events in older adults using trazodone for sleep: A population-based cohort study. *Journal of the American Geriatrics Society*, *68*(1), 127-133.
* Maust, D. T., Kreyenbuhl, J., Stroup, T. S., & Blow, F. C. (2018). Adverse drug events associated with common psychotropic medications used in the elderly. *Journal of Clinical Psychiatry*, *79*(6), 17nr12015.
* Woolcott, J. C., Richardson, K. J., Wiens, M. O., Patel, A., Gerber, B., & Bergman, J. (2009). Falls and psychoactive medication use among older adults: a systematic review. *Archives of Internal Medicine*, *169*(21), 1987-1994.
Q.
Do antidepressants make you feel "numb"?
A.
Some people taking antidepressants feel 'numb' or emotionally 'blunted.' This can happen with different types of antidepressants, like SSRIs and bupropion.
References:
Goodwin GM, Price J, De Bodinat C, & Laredo J. (2017). Emotional blunting with antidepressant treatments. Journal of affective disorders, 28628765.
https://pubmed.ncbi.nlm.nih.gov/28628765/
Peters EM, Balbuena L, & Lodhi RJ. (2022). Emotional blunting with bupropion and serotonin reuptake .... Journal of affective disorders, 36029876.
https://pubmed.ncbi.nlm.nih.gov/36029876/
Opbroek A, Delgado PL, Laukes C, McGahuey C, Katsanis J, Moreno FA, & Manber R. (2002). Emotional blunting associated with SSRI-induced sexual .... The international journal of neuropsychopharmacology, 12135539.
Q.
Can antidepressants cause wait gain?
A.
Yes, some antidepressants can cause weight gain, but it varies depending on the medication and the person taking it. See below to understand more.
References:
Gill H, Gill B, El-Halabi S, Chen-Li D, Lipsitz O, Rosenblat JD, et al. (2020). Antidepressant Medications and Weight Change. Obesity (Silver Spring, Md.), 33022115.
https://pubmed.ncbi.nlm.nih.gov/33022115/
Fava M. (2000). Weight gain and antidepressants. The Journal of clinical psychiatry, 10926053.
https://pubmed.ncbi.nlm.nih.gov/10926053/
Mouawad M, Nabipur L, & Agrawal DK. (2025). Impact of Antidepressants on Weight Gain - PubMed - NIH. Archives of clinical and biomedical research, 40444017.
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