Currently on Antidepressants
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Try one of these related symptoms.
Insomnia
Nausea
Dry mouth
Weight gain
Stomach ache
Sexual dysfunction
Feeling nauseous
Unexplained weight loss
Rapid weight loss
Low libido
Thirsty all the time
Feeling nauseous all the time but not throwing up
About the Symptom
Taking a medication.
Possible Causes
Generally, Currently on antidepressants can be related to:
- Bipolar Disorder
A disorder marked by extreme and persistent shifts in mood that last for weeks to months, from periods of sustained depression to periods of elevated mood and euphoria. The precise cause is unclear, but genetic and environmental factors contribute.
- Osteoporosis
Osteoporosis is a disease that makes your bones weak and brittle. As result, the bones become more prone to break even with minor trauma or stress that would normally not result in a break. It may be caused due to long-term low calcium intake, estrogen deficiencies in women, and an inactive lifestyle.
Doctor's Diagnostic Questions
Your doctor may ask these questions to check for this symptom:
- Are you on any antidepressants?
Reviewed By:
Charles Carlson, DO, MS (Psychiatry)
Dr. Carlson graduated from Touro University in Nevada with a degree in osteopathic medicine. He then trained as a resident in Psychiatry at Case Western Reserve University/University Hospitals where he was also a chief resident and completed a fellowship in Public and Community Psychiatry. After training, he started practicing in | Addiction Psychiatry at the U.S. Department of Veterans Affairs where he also teaches Psychiatry residents.
Yu Shirai, MD (Psychiatry)
Dr. Shirai works at the Yotsuya Yui Clinic for mental health treatment for English and Portuguese-speaking patients. He treats a wide range of patients from neurodevelopmental disorders to dementia in children and participates in knowledge sharing through the Diversity Clinic.
Content updated on Jan 29, 2025
Following the Medical Content Editorial Policy
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FAQs
Q.
Tired of Symptoms? Cyproheptadine and Your Medically Approved Next Steps
A.
Cyproheptadine can help with allergies, migraine prevention, appetite loss, and even serotonin syndrome by blocking histamine and serotonin, but it must be used under medical guidance due to sedation and other risks. There are several factors to consider, including interactions with antidepressants, who should avoid it, and the right medically approved next steps like symptom tracking, med review, and when to seek urgent care. See below to understand more.
References:
* Srinivasan, R., & Jain, S. (2020). Cyproheptadine: A Review of the Clinical Indications, Pharmacokinetics, and Adverse Effects. *Current Drug Discovery, 17*(4), 589-598.
* Chacko, M. P., & O'Toole, L. P. (2020). Cyproheptadine as an appetite stimulant: a narrative review. *Journal of Pediatric Pharmacology and Therapeutics, 25*(4), 312-321.
* Balasubramanian, S., Agarwal, A., & Anand, V. (2022). Cyproheptadine and the serotonin syndrome: A systematic review of cases. *Journal of Clinical Psychopharmacology, 42*(5), 452-458.
* Slavova, I., Nagesh, K. N., & O'Halloran, P. J. (2018). Cyproheptadine in the Management of Post-Traumatic Headache in Children and Adolescents. *Headache: The Journal of Head and Face Pain, 58*(1), 164-167.
* Eikenboom, S. L., Di Lorenzo, C., & Hyman, P. E. (2021). Cyproheptadine for the treatment of cyclic vomiting syndrome: a comprehensive review. *Pediatric Drugs, 23*(5), 473-481.
Q.
Zoloft Side Effects? Why You Feel Worse & Medically Approved Next Steps
A.
It is common to feel temporarily worse on Zoloft, with nausea, sleep changes, and increased anxiety often appearing in the first days and easing within 1 to 3 weeks as your brain adapts, while full mood benefits can take 4 to 8 weeks. Seek urgent care for suicidal thoughts, severe agitation, allergic reactions, or signs of serotonin syndrome, and talk to your doctor if side effects are intense or persist so you can adjust dose or timing rather than stopping suddenly. There are several factors to consider, including practical ways to manage side effects, who is at higher risk, and what changes to discuss with your clinician, so see the complete guidance below.
References:
* Lee, K. C., Lu, C. Y., & Wu, P. C. (2023). Sertraline: an updated review of its use in mental health. *Expert Opinion on Drug Metabolism & Toxicology*, *19*(9), 565-578.
* Rizzato, S., & Biffi, A. (2017). Safety and Tolerability of Serotonin Reuptake Inhibitors: A Systematic Review. *Psychiatric Quarterly*, *88*(3), 567-582.
* Garay, A., Marini, M., Di Landro, C., Perna, G., & Daccò, S. (2021). Paradoxical Anxiety in Patients Treated With Antidepressants: Diagnosis, Clinical Implications, and Treatment. *Frontiers in Psychiatry*, *12*, 697921.
* Heng, S. L., Cheang, H. H., Lai, Y. H., & Ng, C. G. (2022). Identifying and managing antidepressant discontinuation symptoms. *Journal of Clinical Pharmacy and Therapeutics*, *47*(10), 1622-1629.
* Rush, A. J., & Fava, M. (2016). Managing the adverse effects of pharmacotherapy for depression. *F1000Research*, *5*, F1000 Faculty Rev-571.
Q.
Lexapro Side Effects? Why Your Body Reacts & Medical Next Steps
A.
Lexapro commonly causes temporary nausea, headache, GI or sleep changes, sweating, dizziness, fatigue, and a brief spike in anxiety during the first 1 to 2 weeks as your serotonin system adjusts, with most effects easing by 2 to 4 weeks. There are several factors to consider, including rare but serious problems like serotonin syndrome, suicidal thoughts in people under 25, low sodium, and heart rhythm changes that need urgent care, and sexual side effects that may persist; do not stop suddenly, and speak with your doctor if symptoms are severe or lasting or if you see no improvement after 6 to 8 weeks. See the complete details and medical next steps below.
References:
* Gupta S, Gupta M, Marwaha P, et al. Adverse effects of antidepressants. *Handb Clin Neurol*. 2021;182:313-329.
* Volkov I, Druss BG, Adair K, et al. Mechanisms and management of adverse effects of psychiatric medications. *Curr Treat Options Psychiatry*. 2014 Dec;1(4):301-314.
* Wong C, Al-Hajri R, Tandon S, et al. Pharmacological treatment of antidepressant-induced sexual dysfunction. *Expert Opin Pharmacother*. 2022 May;23(7):789-804.
* Haddad P. Antidepressant discontinuation syndrome: a clinical review. *Postgrad Med*. 2012 Jul;124(4):7-17.
* Owens MJ, Nemeroff CB. Escitalopram: a review of its use in the management of major depressive disorder. *Drugs*. 2008;68(14):1955-76.
Q.
Is It Brain Fog? Why Your Mind Feels Heavy and Medical Next Steps for Prozac
A.
There are several factors to consider: a heavy, foggy mind can come from Prozac, from depression or anxiety, poor sleep, stress, medical issues, or medication interactions, and timing around starting or changing your dose can be a key clue. Next steps include tracking symptoms, optimizing sleep and hydration, and speaking with your doctor about dose or timing adjustments, lab checks, interaction review, or switching medicines; do not stop Prozac abruptly, and seek urgent care for sudden confusion, neurological symptoms, serotonin warning signs, or suicidal thoughts. See below for important details and red flags that could change what you do next.
References:
* Munkholm K, Kessing LV, Miskowiak KW. The impact of selective serotonin reuptake inhibitors on executive function: A systematic review. Eur Neuropsychopharmacol. 2019 Jan;29(1):117-133. doi: 10.1016/j.euroneuro.2018.10.012. Epub 2018 Nov 5. PMID: 30404746.
* Baune BT, Ruckhäberle E, Kessing LV, Miskowiak KW, Munkholm K. Subjective cognitive decline in mood disorders: A systematic review and meta-analysis. J Affect Disord. 2021 Mar 1;282:1062-1073. doi: 10.1016/j.jad.2020.12.148. Epub 2021 Jan 18. PMID: 33494050.
* McIntyre RS, Best O, Bowie CR, DeGeorge KM, Kan C, Lam RW, Miskowiak KW, Subramaniapillai M. Cognitive dysfunction in major depressive disorder: clinical challenges and therapeutic options. Neuropsychiatr Dis Treat. 2017 Mar 21;13:717-727. doi: 10.2147/NDT.S128325. PMID: 28367098; PMCID: PMC5368307.
* Molendijk ML, Bus B, Spijker AT, de Kloet ER, Penninx BW, Zitman FG. Selective serotonin reuptake inhibitors (SSRIs) and brain-derived neurotrophic factor (BDNF) in major depression: a comprehensive review. Eur Neuropsychopharmacol. 2014 Dec;24(12):1914-25. doi: 10.1016/j.euroneuro.2014.10.009. Epub 2014 Oct 29. PMID: 25441865.
* Papakostas GI. Cognitive function in major depressive disorder and the effect of antidepressant treatment: a review. CNS Spectr. 2014 Jun;19(3):238-48. doi: 10.1017/S109285291400030X. PMID: 24968254.
Q.
Can antidepressants cause wait gain?
A.
Yes, some antidepressants can cause weight gain, but it varies depending on the medication and the person taking it. See below to understand more.
References:
Gill H, Gill B, El-Halabi S, Chen-Li D, Lipsitz O, Rosenblat JD, et al. (2020). Antidepressant Medications and Weight Change. Obesity (Silver Spring, Md.), 33022115.
https://pubmed.ncbi.nlm.nih.gov/33022115/
Fava M. (2000). Weight gain and antidepressants. The Journal of clinical psychiatry, 10926053.
https://pubmed.ncbi.nlm.nih.gov/10926053/
Mouawad M, Nabipur L, & Agrawal DK. (2025). Impact of Antidepressants on Weight Gain - PubMed - NIH. Archives of clinical and biomedical research, 40444017.
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