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Loss of appetite
Upper abdominal pain
Burning sensation in the chest
Bloated stomach
Stomach feels full
Abdominal pain worse after eating
Stomache after meals
Back pain
Stomach ache
Pain around the belly button
Sharp abdominal pain
Stomach hurts in regular intervals
Not seeing your symptoms? No worries!
Perforated duodenal ulcer is an emergent condition in which the lining of the small intestine erodes away completely leading to bleeding and leakage of the contents into the abdomen.
Treatment for an acute duodenal ulcer with perforation typically requires emergency surgery to repair the perforation and prevent peritonitis. Postoperative care may involve acid-reducing medications and antibiotics.
Reviewed By:
Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.
Aiko Yoshioka, MD (Gastroenterology)
Dr. Yoshioka graduated from the Niigata University School of Medicine. He worked as a gastroenterologist at Saiseikai Niigata Hospital and Niigata University Medical & Dental Hospital before serving as the Deputy Chief of Gastroenterology at Tsubame Rosai Hospital and Nagaoka Red Cross Hospital. Dr. Yoshioka joined Saitama Saiseikai Kawaguchi General Hospital as Chief of Gastroenterology in April 2018.
Content updated on Feb 28, 2025
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1Amini A, Lopez RA. Duodenal Perforation. [Updated 2023 Mar 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing
https://www.ncbi.nlm.nih.gov/books/NBK553084/Shahi R, Siddiqui NH, Khan IA, Bashar MA. Etiologies and Outcomes Following Duodenal Perforation in Acute Peritonitis: A Systematic Review. Cureus. 2024 Nov 28;16(11):e74707. doi: 10.7759/cureus.74707. PMID: 39741604; PMCID: PMC11685785.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11685785/Tarasconi, A., Coccolini, F., Biffl, W.L. et al. Perforated and bleeding peptic ulcer: WSES guidelines. World J Emerg Surg 15, 3 (2020).
https://wjes.biomedcentral.com/articles/10.1186/s13017-019-0283-9Ansari, D., Torén, W., Lindberg, S., Pyrhönen, H. S., & Andersson, R. (2019). Diagnosis and management of duodenal perforations: a narrative review. Scandinavian Journal of Gastroenterology, 54(8), 939–944.
https://www.tandfonline.com/doi/full/10.1080/00365521.2019.1647456