Zollinger-Ellison Syndrome Quiz
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Diarrhea
Heartburn
My stool has an oily or greasy appearance
Loss of appetite
Bloating
Stomachache
Stomachache gets worse when pressed
Not seeing your symptoms? No worries!
What is Zollinger-Ellison Syndrome?
Zollinger-Ellison Syndrome is a rare condition where one or more tumors in the stomach, known as gastrinomas, result in the production of too much gastric acid. The excessive acid may cause peptic ulcers in your stomach or intestine, resulting in symptoms such as heartburn, abdominal pain, acid reflux, and vomiting. Some people with this condition may have a genetic problem known as multiple endocrine neoplasia type 1 (MEN1).
Typical Symptoms of Zollinger-Ellison Syndrome
- Black, shiny stool
- Heartburn that feels like a burning liquid rising up
- Greasy stools that float, associated with problems with digestion
- Pain in the upper abdomen
- Heartburn
- Heartburn with discomfort in the upper stomach area
- Abdominal bloating
- Stomach pain that worsens when the stomach is pressed
Diagnostic Questions for Zollinger-Ellison Syndrome
Your doctor may ask these questions to check for this disease:
- Have you had black, shiny stools?
- Does your heartburn feel like a burning liquid rising up?
- Are your stools greasy and smelly?
- Do you feel pain in your upper abdomen?
- Do you have heartburn?
Treatment of Zollinger-Ellison Syndrome
Treatment of Zollinger-Ellison Syndrome is aimed at managing the excess stomach acid with medicines called proton pump inhibitors. In some cases, surgery is needed remove the tumors. In cases where the tumors are numerous or have spread, other methods to control tumor growth may be recommended, like chemotherapy.
Reviewed By:
Samantha Nazareth, MD (Gastroenterology)
Board-certified gastroenterologist. Experience managing gastrointestinal conditions (GERD, IBS, ulcerative colitis, Crohn’s, celiac disease, NASH) within healthcare organizations (three ambulatory surgical centers, single-specialty practice, multi-specialty practice and solo practice).
Aiko Yoshioka, MD (Gastroenterology)
Dr. Yoshioka graduated from the Niigata University School of Medicine. He worked as a gastroenterologist at Saiseikai Niigata Hospital and Niigata University Medical & Dental Hospital before serving as the Deputy Chief of Gastroenterology at Tsubame Rosai Hospital and Nagaoka Red Cross Hospital. Dr. Yoshioka joined Saitama Saiseikai Kawaguchi General Hospital as Chief of Gastroenterology in April 2018.
Content updated on Feb 19, 2025
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S (2021). Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies. World journal of gastroenterology.
https://pubmed.ncbi.nlm.nih.gov/34629807/Metz DC, Cadiot G, Poitras P, Ito T, Jensen RT (2018). Diagnosis of Zollinger-Ellison syndrome in the era of PPIs, faulty gastrin assays, sensitive imaging and limited access to acid secretory testing. International journal of endocrine oncology.
https://pubmed.ncbi.nlm.nih.gov/29326808/Norton JA, Fraker DL, Alexander HR, Venzon DJ, Doppman JL, Serrano J, Goebel SU, Peghini PL, Roy PK, Gibril F, Jensen RT (1999). Surgery to cure the Zollinger-Ellison syndrome. The New England journal of medicine.
https://pubmed.ncbi.nlm.nih.gov/10460814/