Angioedema Quiz
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Swelling
Swelling of the affected area
Face is swollen
Puffy eyes
Left leg swelling
Edema
The problem area has swollen
Not seeing your symptoms? No worries!
What is Angioedema?
Swelling of the eyes, lips, or other body parts due to an allergic reaction. Triggers typically include external allergens like nuts, crustaceans, bee stings, and drugs. However, in some cases, this condition may be genetic and inherited in the family.
Typical Symptoms of Angioedema
- Blood relatives with frequent abdominal pain
- Frequent stomach or abdominal pain with unknown causes
- Swollen eyelids
- Swelling of the face and lip
- Tooth extraction was within the past 24 hours
- Swelling in any body part
- Swelling in the affected area
- History of connective tissue, autoimmune or rheumatic disease
Diagnostic Questions for Angioedema
Your doctor may ask these questions to check for this disease:
- Do any of your blood relatives have frequent stomach pain?
- Do you have frequent stomach or abdominal pain with unknown causes?
- Do your eyelids look puffy?
- Are your face or lips swollen?
- Did you have a tooth extraction in the last 24 hours?
Treatment of Angioedema
Severe cases require emergency medical care. Steroids and anti-itch medicines can relieve symptoms. Afterward, it's important to identify and avoid the cause of swelling. If the swelling is genetic, a specialist will confirm the diagnosis and recommend treatment options.
Reviewed By:
Maxwell J. Nanes, DO (Emergency Medicine)
Dr Nanes received a doctorate from the Chicago College of Osteopathic Medicine and went on to complete a residency in emergency medicine at the Medical College of Wisconsin. There he trained at Froedtert Hospital and Children's Hospital of Wisconsin in the practice of adult and pediatric emergency medicine. He was a chief resident and received numerous awards for teaching excellence during his time there. | | After residency he took a job at a community hospital where he and his colleagues worked through the toughest days of the COVID-19 pandemic. |
Yukiko Ueda, MD (Dermatology)
Dr. Ueda graduated from the Niigata University School of Medicine and trained at the University of Tokyo Medical School. She is currently a clinical assistant professor at the Department of Dermatology, Jichi Medical University, and holds several posts in the dermatology departments at Kyoto Prefectural University of Medicine, Komagome Hospital, University of Tokyo, and the Medical Center of Japan Red Cross Society.
Content updated on Mar 31, 2024
Following the Medical Content Editorial Policy
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Symptoms Related to Angioedema
Diseases Related to Angioedema
FAQs
Q.
Sudden Swelling? Why Angioedema Occurs & Medically Approved Next Steps
A.
Sudden swelling of the lips, face, or throat is often angioedema caused by allergic histamine reactions, ACE inhibitor blood pressure medicines, hereditary C1 inhibitor deficiency, or sometimes no clear trigger, and it is an emergency if breathing or swallowing are affected. Immediate steps include checking your airway, using your antihistamine or epinephrine for allergy symptoms, stopping ACE inhibitors only with medical guidance, and arranging prompt medical evaluation or specialist care as needed. There are several factors to consider for diagnosis, treatment, and prevention; see the complete details below.
References:
* Betz, J., & Riedl, M. A. (2021). Angioedema: current and future approaches to diagnosis and treatment. Expert Review of Clinical Immunology, 17(5), 473–488. PMID: 33853488
* Maurizio, N., et al. (2020). Angioedema: An Update on Classification, Pathogenesis, and Management. Allergy & Asthma Proceedings, 41(4), 237–246. PMID: 32675039
* Cicardi, M., et al. (2021). Hereditary angioedema: updated recommendations for the management of the disease. Allergy, 76(8), 2636–2647. PMID: 33818780
* Riedl, M. A. (2021). Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema. Immunology and Allergy Clinics of North America, 41(3), 445–458. PMID: 34229712
* Zuraw, B. L. (2020). Acquired angioedema. Journal of Allergy and Clinical Immunology, 145(2), 437–446. PMID: 32033785
Q.
Angioedema? Why Your Face is Swelling and Medically Approved Next Steps
A.
Angioedema is sudden, deeper swelling of the face, lips, eyelids, tongue, or throat that can be triggered by allergies, ACE inhibitor blood pressure medicines, or rare hereditary C1 inhibitor problems, and any breathing or swallowing difficulty is an emergency. If there is airway involvement call emergency services; otherwise seek same-day care, review recent foods and medications, avoid further doses of suspected drugs, and arrange follow up especially for recurrent episodes. There are several factors to consider; see details below for key red flags, how causes change treatment choices such as antihistamines, steroids, epinephrine, or treatments for HAE, and prevention steps that can affect your next healthcare decisions.
References:
* Vliagoftis LMV, Singh AD, Eapen EM. Angioedema: An Update on Classification, Pathogenesis, and Management. Curr Allergy Asthma Rep. 2021 Mar 1;21(3):14.
* Cicardi M, Aberer W, Brummaier T, Farkas H, Haegel P, et al. Angioedema: Current and future treatments. J Allergy Clin Immunol Pract. 2020 Jan;8(1):20-32.e3.
* Longhurst HJ, Farkas H. Hereditary Angioedema: A State-of-the-Art Review on Pathogenesis, Diagnosis, and Management. J Clin Immunol. 2020 Jan;40(1):15-30.
* Bernstein JA, Castaldo AJ, Bernstein DI. Bradykinin-Mediated Angioedema. J Allergy Clin Immunol Pract. 2022 May;10(5):1179-1188.
* Zotter Z, Csuka D, Szabó E, Várbíró S, Kiss-Nemes K, Prohászka Z, Varga L, Farkas H. Acquired C1 Inhibitor Deficiency: What We Know and What We Do Not. J Clin Immunol. 2021 Jan;41(1):28-41.
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Kazandjieva J, Christoff G. Angioedema as a systemic disease. Clin Dermatol. 2019 Nov-Dec;37(6):636-643. doi: 10.1016/j.clindermatol.2019.07.035. Epub 2019 Aug 1. PMID: 31864442.
https://www.sciencedirect.com/science/article/abs/pii/S0738081X19301464?via%3DihubPatel G, Pongracic JA. Hereditary and acquired angioedema. Allergy Asthma Proc. 2019 Nov 1;40(6):441-445. doi: 10.2500/aap.2019.40.4267. PMID: 31690390.
https://www.ingentaconnect.com/content/ocean/aap/2019/00000040/00000006/art00022;jsessionid=2umgk5bcdulne.x-ic-live-03Obtułowicz K. Bradykinin-mediated angioedema. Pol Arch Med Wewn. 2016;126(1-2):76-85. doi: 10.20452/pamw.3273. PMID: 26842379.
https://www.mp.pl/paim/issue/article/3273/