Reviewed By:
Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.
Tatsuya Shiraishi, MD (Cardiology)
Dr. Shiraishi graduated from the Kyoto University School of Medicine. He worked as a cardiologist at Edogawa Hospital, and after joining Ubie, he became the Director of East Nihonbashi Internal Medicine Clinic.
Content updated on Apr 4, 2024
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In aortic stenosis, the valve in a major blood artery branching off the heart (the aorta) is narrowed. This prevents the valve from fully opening and leads to decreased blood flow out of the heart. As a result, the heart has to work harder to get the same amount of blood out. Two things end up happening: the heart eventually starts to fail or you develop symptoms like chest pain, dizziness or feeling like you will pass out because not enough blood is getting to your brain. The main cause is the accumulation of calcium deposits in the valve which increases with age.
Your doctor may ask these questions to check for this disease:
Mild to moderate cases that do not have symptoms usually do not require treatment, rather ongoing monitoring of the stenosis. Severe aortic stenosis requires replacement of the valve.
Joseph J, Naqvi SY, Giri J, Goldberg S. Aortic Stenosis: Pathophysiology, Diagnosis, and Therapy. Am J Med. 2017 Mar;130(3):253-263. doi: 10.1016/j.amjmed.2016.10.005. Epub 2016 Nov 1. PMID: 27810479.
https://www.amjmed.com/article/S0002-9343(16)31073-7/fulltextRoss J Jr, Braunwald E. Aortic stenosis. Circulation. 1968 Jul;38(1 Suppl):61-7. doi: 10.1161/01.cir.38.1s5.v-61. PMID: 4894151.
https://www.ahajournals.org/doi/10.1161/01.CIR.38.1S5.V-61Marquis-Gravel G, Redfors B, Leon MB, Généreux P. Medical Treatment of Aortic Stenosis. Circulation. 2016 Nov 29;134(22):1766-1784. doi: 10.1161/CIRCULATIONAHA.116.023997. PMID: 27895025.
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.023997Zheng KH, Tzolos E, Dweck MR. Pathophysiology of Aortic Stenosis and Future Perspectives for Medical Therapy. Cardiol Clin. 2020 Feb;38(1):1-12. doi: 10.1016/j.ccl.2019.09.010. Epub 2019 Nov 1. PMID: 31753168.
https://www.sciencedirect.com/science/article/abs/pii/S0733865119300888?via%3DihubMale, 30s
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(Sep 25, 2024)
Reviewed By:
Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.
Tatsuya Shiraishi, MD (Cardiology)
Dr. Shiraishi graduated from the Kyoto University School of Medicine. He worked as a cardiologist at Edogawa Hospital, and after joining Ubie, he became the Director of East Nihonbashi Internal Medicine Clinic.
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1