Castleman's Disease / TAFLO Syndrome Quiz
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What is Castleman's Disease / TAFLO Syndrome?
Castleman disease is a rare disorder where lymph node cells overgrow. Often, only one lymph node is affected, usually in the chest or abdomen. The exact cause is unknown but may be linked to human herpesvirus 8 (HHV-8).
Typical Symptoms of Castleman's Disease / TAFLO Syndrome
- Fever above 100.4°F / 38°C lasting 7 days or longer
- Fever
- Swollen lymph nodes or lumps in the neck, armpits, groin, or behind the ears
- Sweating at night requiring change in clothing
- Recurrent fever episodes
- Low red blood cell count on blood test
- Swelling in any body part
- Unintentional weight loss of more than 5% or 4.4lbs/2kg within one month
Diagnostic Questions for Castleman's Disease / TAFLO Syndrome
Your doctor may ask these questions to check for this disease:
- Have you had a fever above 100.4°F / 38°C for 7 days or longer?
- Do you have a fever?
- Do you have any swollen lymph nodes or lumps in your neck, armpits, groin, or behind your ears?
- Do you excessively sweat at night and need to change clothes?
- Do you have recurrent fever episodes?
Treatment of Castleman's Disease / TAFLO Syndrome
In some cases, Castleman disease can be treated surgically. If surgery isn't possible, medication may be prescribed to shrink the lymph node.
Reviewed By:
Saqib Baig, MD, MS (Pulmonology, Critical Care, Internal Medicine)
Dr. Baig graduated from Army Medical College (NUST) Pakistan in 2007. He did his internal medicine training from Baltimore, Maryland, USA during the years 2009-2013. He joined the internal medicine faculty practice at Medical College of Wisconsin in USA for 2 years before pursuing advanced training. He completed his pulmonary disease and critical care medicine fellowship from Rutgers Robert Wood Johnson Medical School from 2015-2018. | | During his fellowship, Dr. Baig completed his master's in health care services management through Rutgers Business School. He currently serves as the medical director of respiratory therapy and pulmonary function lab and the clinical director of the COPD program at the Jane and Leonard Korman Respiratory Institute at Thomas Jefferson University. He holds the Assistant Professor of Medicine rank at Sidney Kimmel Medical College at Thomas Jefferson University. Dr. Baig's interests lie in respiratory physiology, airways disease, and data science.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Feb 13, 2025
Following the Medical Content Editorial Policy
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- A lot of night sweats
- Swollen lymph nodes above collar bone
- Recurrent fevers
- Very sweaty at night
- Periodic fever (>100.4°F / 38°C)
- Swollen armpit
- Fever then no fever then fever again
- Very heavy sweating during sleep
- Swollen lymph nodes continue to grow larger
- Remittent fever of 102.2°F / 39°C
- Extremely high fever of 106.7°F / 41.5°C or higher
- It moves when I touch the lump
- Drenching night sweats
- Fever of 100.4°F / 38°C or more for weeks
- Multiple lymph nodes swollen in my groin
See full list
Symptoms Related to Castleman's Disease / TAFLO Syndrome
Diseases Related to Castleman's Disease / TAFLO Syndrome
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Van Rhee, F., Oksenhendler, E., & Srkalovic, G. (2020). International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease. Blood.
https://ashpublications.org/bloodadvances/article-abstract/4/23/6039/474413Dispenzieri, A., & Fajgenbaum, D. C. (2020). Overview of Castleman disease. Blood, The Journal of the.
https://ashpublications.org/blood/article-abstract/135/16/1353/452573Chan, K. L., Lade, S., & Prince, H. M. (2016). Update and new approaches in the treatment of Castleman disease. Journal of blood.
https://www.tandfonline.com/doi/abs/10.2147/JBM.S60514