Overview
Amenorrhea and dysmenorrhea both affect the menstrual cycle but in opposite ways. Amenorrhea is the absence of periods, often due to hormonal, structural, or lifestyle factors, while dysmenorrhea refers to painful periods caused by uterine contractions or underlying conditions like endometriosis. One is marked by missing periods, the other by intense discomfort during them.
Disease Summaries
Amenorrhea: Amenorrhea is a condition where menarche (first period for a girl) does not occur on time. Typically, absence of first period by age 15 is considered abnormal, but this does vary by ethnicity and location. Causes include problems with malnutrition, genetic disorders, formation of the reproductive system and hormonal imbalances. Primary amenorrhea typically needs evaluation with a specialist to find the correct diagnosis and treatment.
Dysmenorrhea: Dysmenorrhea is the medical term for pain with menstruation. For most women this is mild and tolerable, but for some it can be severe and cause interference in living their life and doing normal activities. Primary or functional dysmenorrhea means the common menstrual cramps/pain that recur with each cycle and is not due to other diseases. This pain is from the natural cramping of the uterus as it sheds it lining, and typically gets better after the first few days. Secondary dysmenorrhea is due to some problem within the reproductive system. Functional dysmenorrhea is usually diagnosed only after other investigations (e.g. ultrasound) do not find any abnormalities responsible for the pain.
Comparing Symptoms
Overlapping Symptoms
- Menstrual irregularities
- Potential impact on fertility
- Acne
- Mood changes
Amenorrhea Specific Symptoms
- No menstrual periods for 3+ months (in non-pregnant individuals)
- Possible hair loss or excess facial hair
- Milky nipple discharge (galactorrhea)
- Headaches or vision changes (if caused by pituitary issues)
- Vaginal dryness
Dysmenorrhea Specific Symptoms
- Cramping in lower abdomen or back
- Nausea or vomiting
- Diarrhea or loose stools
- Headaches
- Fatigue during menstruation
Treatment Approaches
Amenorrhea Treatment Approaches
Treatment depends on the cause. For example, hormone imbalances may be corrected by hormone therapy, and malnourishment can be corrected with improved diet.
Dysmenorrhea Treatment Approaches
Management of symptoms depends on the severity. Many patients with mild symptoms can find relief with over the counter anti-inflammatory medications (NSAIDs) such as ibuprofen or naproxen. Being on hormonal contraception such as birth control pills or an intrauterine device can also help reduce the pain and bleeding related to menstruation. If the pain and bleeding do not respond to such medications, further workup is required to exclude a problem.
Reviewed By:

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Seiji Kanazawa, MD, PHD (Obstetrics and Gynecology (OBGYN))
Dr. Kanazawa graduated from the Niigata University Faculty of Medicine and received his Ph.D. from the Tohoku University Graduate School of Medicine. He is working on the front line of the General Perinatal Center, including the Tokyo Tama General Medical Center and the National Center for Research in Fertility Medicine, where he provides maternal and fetal care and undertakes clinical research. At Ubie, Dr. Kanazawa has been designing the Ubie AI Symptom Checker and has taken on the role of general obstetrics and gynecology consultation at FMC Tokyo Clinic by providing fetal ultrasound and prenatal consultation.
Content updated on Apr 27, 2025
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Marsh CA, Grimstad FW. Primary amenorrhea: diagnosis and management. Obstet Gynecol Surv. 2014 Oct;69(10):603-12. doi: 10.1097/OGX.0000000000000111. PMID: 25336070.
https://journals.lww.com/obgynsurvey/Abstract/2014/10000/Primary_Amenorrhea__Diagnosis_and_Management.18.aspxNIH Stat Pears - Dysmenorrhea
https://www.ncbi.nlm.nih.gov/books/NBK560834/ACOG Patient FAQ
https://www.acog.org/womens-health/faqs/amenorrhea-absence-of-periods#:~:text=Amenorrhea%20is%20the%20absence%20of,for%203%20months%20or%20more.