Overview
Rheumatoid arthritis and lupus are both chronic autoimmune diseases with overlapping symptoms like joint pain and fatigue. However, RA mainly targets the joints, causing progressive damage and deformity, while lupus is a systemic disease that can affect multiple organs, including the skin, kidneys, and brain.
Disease Summaries
Lupus: This is an autoimmune disease caused by the body's immune system attacking organs and cells. The exact cause is unclear, but risk factors include being female, especialy of childbearing age, and heredity. Lupus (SLE) may involve nearly every organ system in the body with a wide range of potential symptoms that often wax and wane over time.
Rheumatoid Arthritis: This is a chronic inflammatory disease where the body's immune system attacks multiple joints, most commonly in the hands and feet. The cause and trigger is unknown.
Comparing Symptoms
Overlapping Symptoms
- Fatigue
- Joint pain and swelling
- Low-grade fever
- Morning stiffness
- Rashes (occasionally)
- Flare-ups and remissions
Lupus Specific Symptoms
- Butterfly-shaped rash on the face
- Sun sensitivity
- Mouth or nose ulcers
- Chest pain with deep breathing (pleuritis)
- Kidney inflammation (lupus nephritis)
- Neurological symptoms (seizures, headaches)
- Can affect skin, joints, kidneys, heart, lungs, and brain
Rheumatoid Arthritis Specific Symptoms
- Symmetrical joint pain and swelling (especially hands, wrists, knees)
- Morning stiffness lasting over 30 minutes
- Joint deformity over time
- Rheumatoid nodules
- Limited to joints and surrounding tissues in most cases
Treatment Approaches
Lupus Treatment Approaches
Though there is no cure, treatment aims to keep the disease inactive and ease symptoms. This is done through medications that suppress or modify the immune system. Creams can be given for rashes, and anti-inflammatory medicines and painkillers for joint pain.
Rheumatoid Arthritis Treatment Approaches
Treatment aims to reduce inflammation and long-term joint damage. Patients may be prescribed immune-suppressing medications and anti-inflammatory medications for pain. Physical exercise is also important for maintaining muscle strength and joint mobility. Smoking cessation and attention to diet are recommended.
Reviewed By:

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Kaito Nakamura, MD (Rheumatology)
Dr. Nakamura is a rheumatologist who has practiced in the Ota Nishinouchi Hospital attached to Ota General Hospital, National Health Insurance Matsudo City Hospital, Chiba University Hospital, and the National Health Insurance Asahi Central Hospital.
Content updated on Apr 27, 2025
Following the Medical Content Editorial Policy
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Sparks JA (2019). Rheumatoid Arthritis. Annals of internal medicine.
https://pubmed.ncbi.nlm.nih.gov/30596879/Lazar S, Kahlenberg JM (Year). Systemic Lupus Erythematosus: New Diagnostic and Therapeutic Approaches. Annual review of medicine.
https://pubmed.ncbi.nlm.nih.gov/35804480/Siegel CH, Sammaritano LR (Year). Systemic Lupus Erythematosus: A Review. JAMA.
https://pubmed.ncbi.nlm.nih.gov/38587826/