Hypergammaglobulinemic Purpura Quiz

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Learn more about Hypergammaglobulinemic purpura

Content updated on Nov 2, 2022

What is hypergammaglobulinemic purpura?

Hypergammaglobulinemic purpura of Waldenström is a condition characterized by hypergammaglobulinemia (high levels of immunoglobulins in the blood), recurring purpura (tiny red/ purple spots due to small blood vessels leaking into the skin), increased Erythrocyte Sedimentation Rate (indicating inflammation in the body) , and rheumatoid factors in the blood (proteins from the immune system that can attack healthy tissue). The cause is unknown, but may be associated with other diseases, like immune system disorders.

Symptoms of hypergammaglobulinemic purpura

  • Purple rash

Questions your doctor may ask to check for hypergammaglobulinemic purpura

Your doctor may ask these questions to diagnose hypergammaglobulinemic purpura

  • Do you have purple spots on your skin?

Treatment for hypergammaglobulinemic purpura

Hypergammaglobulinemic purpura treatment can vary dependng on the severity. Treatment involves medication to suppress inflammation and reduce symptoms.

View the symptoms of Hypergammaglobulinemic purpura

  • Purple rash


  • Gupta L, Edavalath S, Choudhary N, Aggarwal A. Hypergammaglobulinemic Purpura as the First Presentation of Juvenile Onset Sjögren Syndrome-Case-Based Review of Literature. J Clin Rheumatol. 2021 Dec 1;27(8S):S357-S361. doi: 10.1097/RHU.0000000000001582. PMID: 33298812.


  • Finder KA, McCollough ML, Dixon SL, Majka AJ, Jaremko W. Hypergammaglobulinemic purpura of Waldenström. J Am Acad Dermatol. 1990 Oct;23(4 Pt 1):669-76. doi: 10.1016/0190-9622(90)70271-i. PMID: 2229494.


Reviewed By:

Yoshinori Abe

Yoshinori Abe, MD (Internal medicine)

From our team of 50+ doctors

Just 3 minutes.
Developed by doctors.

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Shohei Harase

Shohei Harase, MD


Kameda Medical Center, Japan

Yu Shirai

Yu Shirai, MD


Yotsuya Yui Clinic, Japan

Yoshinori Abe

Yoshinori Abe, MD

Internal medicine

Co-founder of Ubie, Inc.

Rohini R

Rohini R, MD

Ear, nose, throat (ENT)

Bayshore Health Centre, India

Seiji Kanazawa

Seiji Kanazawa, MD, PHD

Obstetrics and gynecology (OBGYN)

National Center for Child Health and Development, Japan

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