Hypergammaglobulinemic Purpura Quiz
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Reviewed By:
Yoshinori Abe, MD (Internal medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
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People with these symptoms also use Ubie's symptom checker to find possible causes
Red spots on the skin
Bruise-like marks on the lower legs
Palpable purpura/raised petechial lesions of the skin
Lesions on the feet
Purpura after abdominal pain
Small, dark purple spots on the skin after having a fever
Purple dots on the legs
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Learn more about Hypergammaglobulinemic purpura
Content updated on Nov 2, 2022
What is hypergammaglobulinemic purpura?
Hypergammaglobulinemic purpura of Waldenström is a condition characterized by hypergammaglobulinemia (high levels of immunoglobulins in the blood), recurring purpura (tiny red/purple spots due to small blood vessels leaking into the skin), increased Erythrocyte Sedimentation Rate (indicating inflammation in the body), and rheumatoid factors in the blood (proteins from the immune system that can attack healthy tissue). The cause is unknown, but may be associated with other diseases, like immune system disorders.
Symptoms of hypergammaglobulinemic purpura
Purple rash
Questions your doctor may ask to check for hypergammaglobulinemic purpura
Your doctor may ask these questions to diagnose hypergammaglobulinemic purpura
Do you have purple spots on your skin?
Treatment for hypergammaglobulinemic purpura
Hypergammaglobulinemic purpura treatment can vary depending on the severity. Treatment involves medication to suppress inflammation and reduce symptoms.
View the symptoms of Hypergammaglobulinemic purpura
Diseases related to Hypergammaglobulinemic purpura
References
Gupta L, Edavalath S, Choudhary N, Aggarwal A. Hypergammaglobulinemic Purpura as the First Presentation of Juvenile Onset Sjögren Syndrome-Case-Based Review of Literature. J Clin Rheumatol. 2021 Dec 1;27(8S):S357-S361. doi: 10.1097/RHU.0000000000001582. PMID: 33298812.
https://journals.lww.com/jclinrheum/Citation/2021/12003/Hypergammaglobulinemic_Purpura_as_the_First.11.aspx
Finder KA, McCollough ML, Dixon SL, Majka AJ, Jaremko W. Hypergammaglobulinemic purpura of Waldenström. J Am Acad Dermatol. 1990 Oct;23(4 Pt 1):669-76. doi: 10.1016/0190-9622(90)70271-i. PMID: 2229494.
https://www.jaad.org/article/0190-9622(90)70271-I/pdf
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Reviewed By:
Yoshinori Abe, MD (Internal medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
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Seiji Kanazawa, MD, PHD
Obstetrics and gynecology (OBGYN)
National Center for Child Health and Development, Japan