Hypergammaglobulinemic Purpura Quiz

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Yoshinori Abe

Yoshinori Abe, MD (Internal medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

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People with these symptoms also use Ubie's symptom checker to find possible causes

  • Red spots on the skin

  • Bruise-like marks on the lower legs

  • Palpable purpura/raised petechial lesions of the skin

  • Lesions on the feet

  • Purpura after abdominal pain

  • Small, dark purple spots on the skin after having a fever

  • Purple dots on the legs

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Learn more about Hypergammaglobulinemic purpura

Content updated on Nov 2, 2022

What is hypergammaglobulinemic purpura?

Hypergammaglobulinemic purpura of Waldenström is a condition characterized by hypergammaglobulinemia (high levels of immunoglobulins in the blood), recurring purpura (tiny red/purple spots due to small blood vessels leaking into the skin), increased Erythrocyte Sedimentation Rate (indicating inflammation in the body), and rheumatoid factors in the blood (proteins from the immune system that can attack healthy tissue). The cause is unknown, but may be associated with other diseases, like immune system disorders.

Symptoms of hypergammaglobulinemic purpura

  • Purple rash

Questions your doctor may ask to check for hypergammaglobulinemic purpura

Your doctor may ask these questions to diagnose hypergammaglobulinemic purpura

  • Do you have purple spots on your skin?

Treatment for hypergammaglobulinemic purpura

Hypergammaglobulinemic purpura treatment can vary depending on the severity. Treatment involves medication to suppress inflammation and reduce symptoms.

View the symptoms of Hypergammaglobulinemic purpura

  • Purple rash

References

  • Gupta L, Edavalath S, Choudhary N, Aggarwal A. Hypergammaglobulinemic Purpura as the First Presentation of Juvenile Onset Sjögren Syndrome-Case-Based Review of Literature. J Clin Rheumatol. 2021 Dec 1;27(8S):S357-S361. doi: 10.1097/RHU.0000000000001582. PMID: 33298812.

    https://journals.lww.com/jclinrheum/Citation/2021/12003/Hypergammaglobulinemic_Purpura_as_the_First.11.aspx

  • Finder KA, McCollough ML, Dixon SL, Majka AJ, Jaremko W. Hypergammaglobulinemic purpura of Waldenström. J Am Acad Dermatol. 1990 Oct;23(4 Pt 1):669-76. doi: 10.1016/0190-9622(90)70271-i. PMID: 2229494.

    https://www.jaad.org/article/0190-9622(90)70271-I/pdf

User testimonials

Reviewed By:

Yoshinori Abe

Yoshinori Abe, MD (Internal medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

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