Hypergammaglobulinemic Purpura Quiz
Check your symptoms and
find possible causes with AI for free
Worried about your symptoms?
Start the Hypergammaglobulinemic Purpura test with our free AI Symptom Checker.
This will help us personalize your assessment.
By starting the symptom checker, you agree to the Privacy Policy and Terms of Use
Purplish rash
Purple discolored spots
Purple spots on the skin
Purpura spots
There are purple bumps on the skin
Not seeing your symptoms? No worries!
What is Hypergammaglobulinemic Purpura?
Hypergammaglobulinemic purpura of Waldenström is a very rare condition caused by underlying dysfunction in the immune system. It consists of three main findings: 1. High levels of immunoglobulins in the blood (hypergammaglobulinemia) 2. Rash of tiny red/purple spots due to small blood vessels leaking into the skin (recurring purpura) 3. A blood test that shows high levels of inflammation in the body (Erythrocyte Sedimentation Rate) The cause is unknown but it is often associated with some underlying disease of the immune system. It commonly occurs in middle-aged women and may be triggered heat exposure, tight-fitting clothing, and extended periods of standing.
Typical Symptoms of Hypergammaglobulinemic Purpura
- Purple marks or spots on the skin
- Skin problem of the legs, in the area between thigh and ankle
- There is a net-like or circular rash on parts of my skin
- Skin problems
Diagnostic Questions for Hypergammaglobulinemic Purpura
Your doctor may ask these questions to check for this disease:
- Have you noticed any purple marks or spots on your skin?
- Are there any skin issues on your leg/s?
- Do you have a net-like or circular rash on your skin?
- Do you have any skin problems
Treatment of Hypergammaglobulinemic Purpura
Hypergammaglobulinemic purpura treatment can vary depending on the severity but is generally a self-limited condition that goes away on its own. If more severe, treatment involves medication to suppress inflammation, reduce symptoms and find an underlying immune disease that might be causing it.
Reviewed By:
Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Mar 31, 2024
Following the Medical Content Editorial Policy
Was this page helpful?
Tell your friends about us.
We would love to help them too.
Think you might have
Hypergammaglobulinemic Purpura?
Try a symptom check testHow Ubie Can Help You
With a free 3-min Hypergammaglobulinemic Purpura quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.
This questionnaire is customized to your situation and symptoms, including the following personal information:
Biological Sex - helps us provide relevant suggestions for male vs. female conditions.
Age - adjusts our guidance based on any age-related health factors.
History - considers past illnesses, surgeries, family history, and lifestyle choices.
Your symptoms
Our AI
Your report
Your personal report will tell you
✔ When to see a doctor
✔︎ What causes your symptoms
✔︎ Treatment information etc.
People with similar symptoms also use Ubie's symptom checker to find possible causes
- Red spots on the skin
- Bruise-like marks on the lower legs
- Rashes
- Purplish-red rash with raised pinpoint-sized spots on the skin, known as petechiae
- Lesions on the feet
- Developed purpura following abdominal pain
- Small, dark purple spots on the skin after having a fever
- Leg rash
- Purple dots on the legs
- Purple spots on the fingers
- Purplish spotty rashes, occurring after tummy pain
- Hand skin is dry
- Bumpy, reddish-purple rash
- There is a sore on the side
- Rash on the wrist
See full list
Symptoms Related to Hypergammaglobulinemic Purpura
Diseases Related to Hypergammaglobulinemic Purpura
Ubie is supervised by 50+ medical experts worldwide
Our symptom checker AI is continuously refined with input from experienced physicians, empowering them to make more accurate diagnoses.
Ubie is recognized by healthcare and tech leaders
“World’s Best Digital
Health Companies”
Newsweek 2024
“Best With AI”
Google Play Best of 2023
“Best in Class”
Digital Health Awards 2023 (Quarterfinalist)
Which is the best Symptom Checker?
Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Gupta L, Edavalath S, Choudhary N, Aggarwal A. Hypergammaglobulinemic Purpura as the First Presentation of Juvenile Onset Sjögren Syndrome-Case-Based Review of Literature. J Clin Rheumatol. 2021 Dec 1;27(8S):S357-S361. doi: 10.1097/RHU.0000000000001582. PMID: 33298812.
https://journals.lww.com/jclinrheum/Citation/2021/12003/Hypergammaglobulinemic_Purpura_as_the_First.11.aspxFinder KA, McCollough ML, Dixon SL, Majka AJ, Jaremko W. Hypergammaglobulinemic purpura of Waldenström. J Am Acad Dermatol. 1990 Oct;23(4 Pt 1):669-76. doi: 10.1016/0190-9622(90)70271-i. PMID: 2229494.
https://www.jaad.org/article/0190-9622(90)70271-I/pdfDeBiasio C, Cyr J, Petkiewicz S, Glassman SJ. Hypergammaglobulinemic purpura of Waldenström-Unusual and impressive case in a patient with myeloma: A case report. SAGE Open Med Case Rep. 2022 Mar 22;10:2050313X221086321. doi: 10.1177/2050313X221086321. PMID: 35341104; PMCID: PMC8943611.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943611/