Lambert-Eaton Syndrome Quiz

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Reviewed By:

Benjamin Kummer, MD

Benjamin Kummer, MD (Neurology)

Dr Kummer is Assistant Professor of Neurology at the Icahn School of Medicine at Mount Sinai (ISMMS), with joint appointment in Digital and Technology Partners (DTP) at the Mount Sinai Health System (MSHS) as Director of Clinical Informatics in Neurology. As a triple-board certified practicing stroke neurologist and informaticist, he has successfully improved clinical operations at the point of care by acting as a central liaison between clinical neurology faculty and DTP teams to implement targeted EHR configuration changes and workflows, as well as providing subject matter expertise on health information technology projects across MSHS. | Dr Kummer also has several years’ experience building and implementing several informatics tools, presenting scientific posters, and generating a body of peer-reviewed work in “clinical neuro-informatics” – i.e., the intersection of clinical neurology, digital health, and informatics – much of which is centered on digital/tele-health, artificial intelligence, and machine learning. He has spearheaded the Clinical Neuro-Informatics Center in the Department of Neurology at ISMMS, a new research institute that seeks to establish the field of clinical neuro-informatics and disseminate knowledge to the neurological community on the effects and benefits of clinical informatics tools at the point of care.

Shohei Harase, MD

Shohei Harase, MD (Neurology)

Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.

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People with similar symptoms also use Ubie's symptom checker to find possible causes

  • Trouble standing

  • Walking as if dragging

  • Cannot stand up

  • Feeling weak after a panic attack

  • Having hard time rising from a chair

  • Abnormal gait

  • Problem standing up from a chair

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Learn more about Lambert-Eaton syndrome

Content updated on Nov 7, 2023

What is Lambert-Eaton syndrome?

Lambert-Eaton syndrome is a condition where a person's immune system attacks the connections between the nerves and the muscles. This usually causes muscle weakness and fatigue. This condition is most often seen in people with small cell lung cancer, those with immune system problems, or rarely other types of cancer such as lymphoma.

Symptoms of Lambert-Eaton syndrome

  • History of lung cancer

  • Difficulty standing up from sitting position

  • Difficulty in walking

  • Weakness in arms or legs

  • Unable to move both legs

  • Easily fatigued

  • Drooping eyelids

  • Double vision

Questions your doctor may ask to check for Lambert-Eaton syndrome

Your doctor may ask these questions to diagnose Lambert-Eaton syndrome

  • Have you ever had lung cancer?

  • Do you have difficulty in getting up from a chair on your own?

  • Do you have any difficulty walking?

  • Do you feel any weakness in your arms or legs?

  • Are you unable to move both legs?

Treatment for Lambert-Eaton syndrome

There is no cure for Lambert-Eaton syndrome but treatment usually involves medications that improve the communication between nerves and muscles, or medications to reduce the activity of the immune system.

View the symptoms of Lambert-Eaton syndrome

References

  • Lang B, Newsom-Davis J, Wray D, Vincent A, Murray N. Autoimmune aetiology for myasthenic (Eaton-Lambert) syndrome. Lancet. 1981 Aug 1;2(8240):224-6. doi: 10.1016/s0140-6736(81)90474-8. PMID: 6114283.

    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(81)90474-8/fulltext

  • Kesner VG, Oh SJ, Dimachkie MM, Barohn RJ. Lambert-Eaton Myasthenic Syndrome. Neurol Clin. 2018 May;36(2):379-394. doi: 10.1016/j.ncl.2018.01.008. PMID: 29655456; PMCID: PMC6690495.

    https://www.sciencedirect.com/science/article/abs/pii/S0733861918300082?via%3Dihub

  • Sanders DB, Guptill JT. Myasthenia gravis and Lambert-Eaton myasthenic syndrome. Continuum (Minneap Minn). 2014 Oct;20(5 Peripheral Nervous System Disorders):1413-25. doi: 10.1212/01.CON.0000455873.30438.9b. PMID: 25299290.

    https://journals.lww.com/continuum/abstract/2014/10000/myasthenia_gravis_and_lambert_eaton_myasthenic.23.aspx

User testimonials

Reviewed By:

Benjamin Kummer, MD

Benjamin Kummer, MD (Neurology)

Dr Kummer is Assistant Professor of Neurology at the Icahn School of Medicine at Mount Sinai (ISMMS), with joint appointment in Digital and Technology Partners (DTP) at the Mount Sinai Health System (MSHS) as Director of Clinical Informatics in Neurology. As a triple-board certified practicing stroke neurologist and informaticist, he has successfully improved clinical operations at the point of care by acting as a central liaison between clinical neurology faculty and DTP teams to implement targeted EHR configuration changes and workflows, as well as providing subject matter expertise on health information technology projects across MSHS. | Dr Kummer also has several years’ experience building and implementing several informatics tools, presenting scientific posters, and generating a body of peer-reviewed work in “clinical neuro-informatics” – i.e., the intersection of clinical neurology, digital health, and informatics – much of which is centered on digital/tele-health, artificial intelligence, and machine learning. He has spearheaded the Clinical Neuro-Informatics Center in the Department of Neurology at ISMMS, a new research institute that seeks to establish the field of clinical neuro-informatics and disseminate knowledge to the neurological community on the effects and benefits of clinical informatics tools at the point of care.

Shohei Harase, MD

Shohei Harase, MD (Neurology)

Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.

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