Malignant Syndrome Quiz
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Learn more about Malignant syndrome
Content updated on Sep 20, 2022
It is also called neuroleptic malignant syndrome (NMS). It's a rare and serious reaction to certain medicines. Symptoms typically start within hours to days after exposure to the medication, but sometimes can happen after two weeks up to a month from starting it. Most common causative medications include antipsychotics and occasionally drugs used to treat or prevent vomiting, Parkinson's disease etc. Symptoms include dangerously high body temperature, muscular rigidity, and severe agitation and altered mental status.
Fever
Fine tremor of the hands and fingers
Feel the heart is pounding
Muscle pain
My brain is not functioning right now
On psychiatric medications or sleeping pills
Losing consciousness
Sweating at the moment
Your doctor may ask these questions to diagnose malignant syndrome
Do you have a fever?
Do you have a slight trembling of your fingers?
Do you feel your heart is pounding?
Do you have any muscle pain?
Do you have problems focusing or a reduced sense of awareness in your surroundings?
This is a life threatening emergency. With timely treatment, patients usually recover completely from neuroleptic malignant syndrome (NMS). The medication that has caused NMS should be discontinued. Treatment in hospital for monitoring is required. Patients often need body cooling procedures and IV fluids. Some medications can help including muscle relaxants and central nervous system depressants.
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Seiji Kanazawa, MD, PHD
Obstetrics and gynecology (OBGYN)
National Center for Child Health and Development, Japan