Malignant Syndrome Quiz

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Reviewed By:

Maxwell J. Nanes

Maxwell J. Nanes, DO (Emergency department)

Dr Nanes received a doctorate from the Chicago College of Osteopathic Medicine and went on to complete a residency in emergency medicine at the Medical College of Wisconsin. There he trained at Froedtert Hospital and Children's Hospital of Wisconsin in the practice of adult and pediatric emergency medicine. He was a chief resident and received numerous awards for teaching excellence during his time there. | | After residency he took a job at a community hospital where he and his colleagues worked through the toughest days of the COVID-19 pandemic. |

Yoshinori Abe

Yoshinori Abe, MD (Internal medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

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Learn more about Malignant syndrome

Content updated on Sep 20, 2022

What is malignant syndrome?

It is also called neuroleptic malignant syndrome (NMS). It's a rare and serious reaction to certain medicines. Symptoms typically start within hours to days after exposure to the medication, but sometimes can happen after two weeks up to a month from starting it. Most common causative medications include antipsychotics and occasionally drugs used to treat or prevent vomiting, Parkinson's disease etc. Symptoms include dangerously high body temperature, muscular rigidity, and severe agitation and altered mental status.

Symptoms of malignant syndrome

  • Fever

  • Fine tremor of the hands and fingers

  • Feel the heart is pounding

  • Muscle pain

  • My brain is not functioning right now

  • On psychiatric medications or sleeping pills

  • Losing consciousness

  • Sweating at the moment

Questions your doctor may ask to check for malignant syndrome

Your doctor may ask these questions to diagnose malignant syndrome

  • Do you have a fever?

  • Do you have a slight trembling of your fingers?

  • Do you feel your heart is pounding?

  • Do you have any muscle pain?

  • Do you have problems focusing or a reduced sense of awareness in your surroundings?

Treatment for malignant syndrome

This is a life threatening emergency. With timely treatment, patients usually recover completely from neuroleptic malignant syndrome (NMS). The medication that has caused NMS should be discontinued. Treatment in hospital for monitoring is required. Patients often need body cooling procedures and IV fluids. Some medications can help including muscle relaxants and central nervous system depressants.

View the symptoms of Malignant syndrome

Reviewed By:

Maxwell J. Nanes

Maxwell J. Nanes, DO (Emergency department)

Dr Nanes received a doctorate from the Chicago College of Osteopathic Medicine and went on to complete a residency in emergency medicine at the Medical College of Wisconsin. There he trained at Froedtert Hospital and Children's Hospital of Wisconsin in the practice of adult and pediatric emergency medicine. He was a chief resident and received numerous awards for teaching excellence during his time there. | | After residency he took a job at a community hospital where he and his colleagues worked through the toughest days of the COVID-19 pandemic. |

Yoshinori Abe

Yoshinori Abe, MD (Internal medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

From our team of 50+ doctors

Just 3 minutes.
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Ubie is supervised by 50+ medical experts worldwide

Shohei Harase

Shohei Harase, MD

Neurology

Kameda Medical Center, Japan

Yu Shirai

Yu Shirai, MD

Psychiatry

Yotsuya Yui Clinic, Japan

Yoshinori Abe

Yoshinori Abe, MD

Internal medicine

Co-founder of Ubie, Inc.

Rohini R

Rohini R, MD

Ear, nose, throat (ENT)

Bayshore Health Centre, India

Seiji Kanazawa

Seiji Kanazawa, MD, PHD

Obstetrics and gynecology (OBGYN)

National Center for Child Health and Development, Japan

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