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Have a fever
Hands have fine tremors
Heart palpitations
Muscle pain
Joint pain that is always there
Brain fog
Sweating
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What is Neuroleptic Malignant Syndrome?
This is a rare and serious reaction to certain medications. Symptoms usually begin within hours to days after exposure to the medication but can sometimes occur up to a month after starting it. Common causative medications include antipsychotics and occasionally drugs used to treat or prevent vomiting, Parkinson's disease, etc. Symptoms include dangerously high body temperature, muscular rigidity, and severe agitation and altered mental status.
Typical Symptoms of Neuroleptic Malignant Syndrome
- Fainting
- Fever
- Fine tremors of the hands or fingers
- Taking psychiatric medications or sleeping pills
- Recent changes in mental state
- Blood in urine
- Heart pounding
- Difficulty thinking clearly
Diagnostic Questions for Neuroleptic Malignant Syndrome
Your doctor may ask these questions to check for this disease:
- Have you fainted recently?
- Do you have a fever?
- Do you experience fine tremors in your hands or fingers?
- Are you taking any psychiatric medications or sleeping pills?
- Recently, are you more confused than before?
Treatment of Neuroleptic Malignant Syndrome
This is a life-threatening emergency. With timely treatment, patients typically recover completely from neuroleptic malignant syndrome (NMS). The medication causing NMS should be discontinued. Hospital treatment for monitoring is required. Patients often need body cooling procedures and IV fluids. Some medications can help, including muscle relaxants and central nervous system depressants.
Reviewed By:
Maxwell J. Nanes, DO (Emergency Medicine)
Dr Nanes received a doctorate from the Chicago College of Osteopathic Medicine and went on to complete a residency in emergency medicine at the Medical College of Wisconsin. There he trained at Froedtert Hospital and Children's Hospital of Wisconsin in the practice of adult and pediatric emergency medicine. He was a chief resident and received numerous awards for teaching excellence during his time there. | | After residency he took a job at a community hospital where he and his colleagues worked through the toughest days of the COVID-19 pandemic. |
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Feb 13, 2025
Following the Medical Content Editorial Policy
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People with similar symptoms also use Ubie's symptom checker to find possible causes
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See full list
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Wijdicks, E. F. M., & Ropper, A. H. (2024). Neuroleptic malignant syndrome. New England Journal of Medicine.
https://www.nejm.org/doi/full/10.1056/NEJMra2404606Pileggi, D. J., & Cook, A. M. (2016). Neuroleptic malignant syndrome: focus on treatment and rechallenge. Annals of Pharmacotherapy.
https://journals.sagepub.com/doi/abs/10.1177/1060028016657553Modi, S., Dharaiya, D., Schultz, L., & Varelas, P. (2016). Neuroleptic malignant syndrome: complications, outcomes, and mortality. Neurocritical care.
https://link.springer.com/article/10.1007/s12028-015-0162-5