Malignant Syndrome Quiz

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Reviewed By:

Maxwell J. Nanes, DO

Maxwell J. Nanes, DO (Emergency department)

Dr Nanes received a doctorate from the Chicago College of Osteopathic Medicine and went on to complete a residency in emergency medicine at the Medical College of Wisconsin. There he trained at Froedtert Hospital and Children's Hospital of Wisconsin in the practice of adult and pediatric emergency medicine. He was a chief resident and received numerous awards for teaching excellence during his time there. | | After residency he took a job at a community hospital where he and his colleagues worked through the toughest days of the COVID-19 pandemic. |

Yoshinori Abe, MD

Yoshinori Abe, MD (Internal medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

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With an easy 3-min questionnaire, Ubie's AI-powered system will generate a free report on possible causes.

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  • Malignant Syndrome as well as similar diseases can be checked at the same time.

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People with similar symptoms also use Ubie's symptom checker to find possible causes

  • Blacking out

  • Feel anxiety suddenly

  • Felt nauseous then fainted

  • Fever then no fever then fever again

  • Sweating followed by fainting

  • Confusion

  • Fainting followed by a headache

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Learn more about Malignant Syndrome

Content updated on Jan 19, 2024

What is malignant syndrome?

Also known as neuroleptic malignant syndrome (NMS), it is a rare and serious reaction to certain medications. Symptoms usually begin within hours to days after exposure to the medication but can sometimes occur up to a month after starting it. Common causative medications include antipsychotics and occasionally drugs used to treat or prevent vomiting, Parkinson's disease, etc. Symptoms include dangerously high body temperature, muscular rigidity, and severe agitation and altered mental status.

Symptoms of malignant syndrome

  • Losing consciousness

  • Fever

  • Fine tremor of the hands and fingers

  • On psychiatric medications or sleeping pills

  • Recent changes in mental state

  • Bloody or red urine

  • Feel the heart is pounding

  • Muscle pain

Questions your doctor may ask to check for malignant syndrome

  • Have you temporarily lost consciousness?

  • Do you have a fever?

  • Do your fingers tremble slightly?

  • Are you taking any psychiatric medications or sleeping pills?

  • Recently, are you more confused than before?

Treatment for malignant syndrome

This is a life-threatening emergency. With timely treatment, patients typically recover completely from neuroleptic malignant syndrome (NMS). The medication causing NMS should be discontinued. Hospital treatment for monitoring is required. Patients often need body cooling procedures and IV fluids. Some medications can help, including muscle relaxants and central nervous system depressants.

View the symptoms of Malignant Syndrome

User testimonials

Reviewed By:

Maxwell J. Nanes, DO

Maxwell J. Nanes, DO (Emergency department)

Dr Nanes received a doctorate from the Chicago College of Osteopathic Medicine and went on to complete a residency in emergency medicine at the Medical College of Wisconsin. There he trained at Froedtert Hospital and Children's Hospital of Wisconsin in the practice of adult and pediatric emergency medicine. He was a chief resident and received numerous awards for teaching excellence during his time there. | | After residency he took a job at a community hospital where he and his colleagues worked through the toughest days of the COVID-19 pandemic. |

Yoshinori Abe, MD

Yoshinori Abe, MD (Internal medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

From our team of 50+ doctors

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Developed by doctors.

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Maxwell J. Nanes, DO

Maxwell J. Nanes, DO

Emergency department

Waukesha Memorial Hospital, Waukesha Wisconsin, USA

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Caroline M. Doan, DO

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Benjamin Kummer, MD

Neurology

Icahn School of Medicine at Mount Sinai

Charles Carlson, DO, MS

Charles Carlson, DO, MS

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U.S. Department of Veterans Affairs

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Dale Mueller, MD

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