What are the symptoms of mixed connective tissue disease?

Symptoms of MIXED CONNECTIVE TISSUE DISEASE are: (1) Fingers and toes turn from pale blue to purplish-red when in the cold. (2) Upper jaw pain. (3) Facial pain. (4) Joints feel warm. (5) Feeling breathless. (6) Skin over my fingers are hardened. (7) Fever

Mixed Connective Tissue Disease Quiz

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Reviewed By:

Kaito Nakamura, MD (Rheumatology & Allergy)

Dr. Nakamura is a rheumatologist who has practiced in the Ota Nishinouchi Hospital attached to Ota General Hospital, National Health Insurance Matsudo City Hospital, Chiba University Hospital, and the National Health Insurance Asahi Central Hospital.

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Learn more about Mixed connective tissue disease

Content updated on Sep 20, 2022

What is mixed connective tissue disease?

Mixed connective tissue disease (MCTD) is a rare autoimmune disorder (the immune system mistakenly attacks the body's own tissues). Risk factors include, family history of connective tissue disease, exposure to certain viruses or chemicals. It's most common in women in their 20s and 30s. Children may also be affected.

Symptoms of mixed connective tissue disease

Fingers and toes turn from pale blue to purplish-red when in the cold
Upper jaw pain
Facial pain
Joints feel warm
Feeling breathless
Skin over my fingers are hardened
Fever

Questions your doctor may ask to check for mixed connective tissue disease

Your doctor may ask these questions to diagnose mixed connective tissue disease

Have you ever experienced your fingers and toes turning from blue to purple or red in a cold environment?
Do you have upper jaw pain?
Do you have pain in the face?
Are your joints hot to touch?
Are you breathless or having hard time breathing?

Treatment for mixed connective tissue disease

Mixed connective tissue disease (MCTD) has no cure. It can be controlled with the help of medication to suppress the immune cells, which are effective especially if diagnosed early.

View the symptoms of Mixed connective tissue disease

Diseases related to Mixed connective tissue disease

References

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https://link.springer.com/article/10.1007/s10238-020-00606-7
Pepmueller PH. Undifferentiated Connective Tissue Disease, Mixed Connective Tissue Disease, and Overlap Syndromes in Rheumatology. Mo Med. 2016 Mar-Apr;113(2):136-40. PMID: 27311225; PMCID: PMC6139943.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139943/
Ortega-Hernandez OD, Shoenfeld Y. Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment. Best Pract Res Clin Rheumatol. 2012 Feb;26(1):61-72. doi: 10.1016/j.berh.2012.01.009. PMID: 22424193.
https://www.sciencedirect.com/science/article/abs/pii/S1521694212000101?via%3Dihub
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https://www.sciencedirect.com/science/article/abs/pii/S0272523119300292?via%3Dihub
Berard RA, Laxer RM. Pediatric Mixed Connective Tissue Disease. Curr Rheumatol Rep. 2016 May;18(5):28. doi: 10.1007/s11926-016-0576-x. PMID: 27032791.
https://link.springer.com/article/10.1007/s11926-016-0576-x