Sjogren Syndrome Quiz
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Dry eyes
Erythema
Joint pain
Dry mouth
Dry mouth at night
Eye irritation
Burning eyes
Swollen lymph nodes under jaw one side
Joint pain and stiffness all over body
Big toe joint pain
Hip joint pain
Extreme fatigue
Not seeing your symptoms? No worries!
What is Sjogren Syndrome?
An autoimmune disease where the immune system attacks the organs that produce tears and saliva, resulting in dry eyes and dry mouth. In some cases, internal organs can also be gradually affected. Disease severity is highly variable.
Typical Symptoms of Sjogren Syndrome
- Whole body pain
- Fingers turn white, blue, then red when exposed to cold
- Bloodshot eyes
- Warmth in the joints
- Feels a hard lump in upper right abdomen
- Swelling below the ear/s
- Experience of reduced tear production
- Hair loss
Diagnostic Questions for Sjogren Syndrome
Your doctor may ask these questions to check for this disease:
- Do you have pain all over your body?
- Do your fingers turn white, blue, then red when exposed to cold?
- Do you have bloodshot (red) eyes?
- Do you feel warmth in your joints?
- Do you feel a hard lump in your upper right abdomen?
Treatment of Sjogren Syndrome
Treatment aims to keep the eyes and mouth moist, preventing further damage to those organs protected by saliva and tears. This is done through regular eye drops and sprays. Some patients may also experience joint pains or rashes; these symptoms can be managed with anti-inflammatory medicine and creams.
Reviewed By:
Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.
Kaito Nakamura, MD (Rheumatology)
Dr. Nakamura is a rheumatologist who has practiced in the Ota Nishinouchi Hospital attached to Ota General Hospital, National Health Insurance Matsudo City Hospital, Chiba University Hospital, and the National Health Insurance Asahi Central Hospital.
Content updated on Dec 5, 2025
Following the Medical Content Editorial Policy
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How Ubie Can Help You
With a free 3-min Sjogren Syndrome quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.
This questionnaire is customized to your situation and symptoms, including the following personal information:
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History - considers past illnesses, surgeries, family history, and lifestyle choices.
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- My whole body aches and I feel weak
- Cold fingers/toes
- Body aches and chills
- Intensely red eye
- One or more joints feel warm
- Raynaud's
- Whole body aches no fever
- Swelling under ribs right side
- My whole body hurts
- Eye congestion
- Discoloration of the fingers
- Whole body pain
- Knees hot, no pain
- Hand color changes in cold places
- Bloodshot eyes
See full list
Symptoms Related to Sjogren Syndrome
Diseases Related to Sjogren Syndrome
FAQs
Q.
Sjögren’s Syndrome? Why Your Glands Are Failing & Medical Next Steps
A.
Sjögren’s syndrome is an autoimmune condition that makes your immune system attack the tear and salivary glands, leading to chronic dry eyes and mouth with fatigue and joint pain, and it can also affect skin, lungs, kidneys, and nerves with a small increased lymphoma risk. Next steps span proper diagnosis with specific antibodies plus tear and salivary tests, targeted eye and mouth care, dental protection, and systemic therapy like hydroxychloroquine when organs are involved; there are several factors to consider, and key red flags, monitoring schedules, and treatment choices that could change your next steps are explained below.
References:
* Alunno A, Gerli R. Sjögren's syndrome: A critical overview of the current understanding of its pathophysiology and treatment. Autoimmun Rev. 2023 Nov;22(11):103443. doi: 10.1016/j.autrev.2023.103443. Epub 2023 Sep 15. PMID: 37722797.
* Wang S, Zhang X, Li H. Primary Sjögren's Syndrome: Recent Updates in Pathogenesis and Treatment. Front Immunol. 2022 Mar 28;13:847190. doi: 10.3389/fimmu.2022.847190. PMID: 35422891; PMCID: PMC9000958.
* Brito-Zerón P, Acar-Deniz N, Seror R, Ramos-Casals M. Sjögren's Syndrome: Diagnosis and Management. Clin Rev Allergy Immunol. 2020 Apr;58(2):299-307. doi: 10.1007/s12016-019-08764-1. PMID: 31754877.
* Papaspyridonos M, Tsiakou EK, Kapsogeorgou EK, Tzioufas AG. Primary Sjögren's Syndrome: From Pathogenesis to Novel Therapeutic Approaches. Front Immunol. 2022 Feb 21;13:834372. doi: 10.3389/fimmu.2022.834372. PMID: 35265147; PMCID: PMC8899895.
* Mariette X, Criswell LA. Primary Sjögren's Syndrome. N Engl J Med. 2024 Jan 18;390(3):260-271. doi: 10.1056/NEJMra2307824. PMID: 38231575.
Q.
Is it Sjogren’s Syndrome? Why your body is always dry & medical next steps.
A.
There are several factors to consider: while Sjogren’s syndrome can explain persistent dry eyes and mouth with fatigue or joint pain, common alternatives like medications, menopause, diabetes, thyroid problems, or dehydration can also cause body-wide dryness. See below for the complete steps on diagnosis and care, including which blood, eye, and salivary tests to ask about, key complications like dental decay and corneal damage to watch for, and practical next steps such as tracking symptoms, reviewing medications, and scheduling a primary care visit with possible rheumatology referral.
References:
* Brito-Zerón P, Baldini C, Gottenberg JE, et al. Update on the classification of Sjögren's syndrome. Rheumatology (Oxford). 2021 May 1;60(5):2131-2140. doi: 10.1093/rheumatology/keaa799. PMID: 33454659.
* Baer AN. Clinical manifestations of Sjögren's syndrome: More than just dry eyes and mouth. F1000Res. 2019 Jul 24;8:F1000 Faculty Rev-1249. doi: 10.12688/f1000research.19641.1. PMID: 31440337.
* Ramos-Casals M, Brito-Zerón P, Bombardieri S, et al. Primary Sjögren syndrome: New clinical and therapeutic insights. Nat Rev Rheumatol. 2020 Aug;16(8):417-431. doi: 10.1038/s41584-020-0445-5. PMID: 32601449.
* Mariette X, Criswell LA. Sjögren's syndrome. Lancet. 2017 Mar 4;389(10072):917-931. doi: 10.1016/S0140-6736(16)30952-7. PMID: 28271871.
* Shiboski CH, Shiboski SC, Seror R, et al. American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Approach From the Sjögren's International Collaborative Clinical Alliance. Arthritis Rheumatol. 2017 Jan;69(1):35-42. doi: 10.1002/art.39460. PMID: 27912442.
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Which is the best Symptom Checker?
Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Ramos-Casals M, Brito-Zerón P, Sisó-Almirall A, Bosch X. Primary Sjogren syndrome. BMJ. 2012 Jun 14;344:e3821. doi: 10.1136/bmj.e3821. PMID: 22700787.
https://www.bmj.com/content/344/bmj.e3821Fox RI. Sjögren's syndrome. Lancet. 2005 Jul 23-29;366(9482):321-31. doi: 10.1016/S0140-6736(05)66990-5. PMID: 16039337.
https://pubmed.ncbi.nlm.nih.gov/16039337/#:~:text=Sj%C3%B6gren's%20syndrome%20is%20a%20chronic,infiltrates%20of%20the%20affected%20glands.