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A disorder of an overactive thyroid gland. This causes overactivity of thyroid hormones that are needed for growth, development, and metabolism. Causes include viral infections, brain disorders, and autoimmunity (where the body's immune system attacks itself). Symptoms include weight loss, tremors and palpitations and/or rapid heart rate.
Your doctor may ask these questions to check for this disease:
The treatment aims to stop the thyroid from overproducing hormones. Options include anti-thyroid medications, radioactive iodine therapy, and surgery to remove the thyroid. At the same time, medications may be prescribed to control symptoms like palpitations and anxiety.
Reviewed By:
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Hidetaka Hamasaki, MD (Endocrinology)
Dr. Hamasaki graduated from the Hiroshima University School of Medicine and the Graduate School of Medicine, Jichi Medical University. He completed his residency at the Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine Hospital and the Department of Internal Medicine, Kohnodai Hospital, National Center for Global Health and Medicine. He has served in the National Center for Global Health and Medicine Hospital and Kohnodai Hospital and joined Hamasaki Clinic in April 2017. Dr. Hamasaki specializes in diabetes and treats a wide range of internal medicine and endocrine disorders.
Content updated on May 13, 2024
Following the Medical Content Editorial Policy
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Male, 30s
I was really impressed with Ubie Health's symptom checker. It covered all my symptoms including fatigue, depression, and excessive drooling which is not something I have seen on other platforms. The results pointed me toward possible hyperthyroidism, so I scheduled an appointment with my doctor to figure out the best course of action. Its a great tool for getting quick results so I can have more of an idea of what's going on with me health-wise. I also liked how it showed me that I wasn't alone! It said there were 168 other people who had symptoms just like me in the past six months, so I didn't feel weird or embarrassed about my symptoms anymore. I highly recommend this site.
(Mar 18, 2025)
Q.
Racing Heart? Why Your Thyroid Is Overactive & Medically Approved Next Steps
A.
A racing or pounding heartbeat can be caused by hyperthyroidism, when excess thyroid hormone speeds your heart and metabolism, often with palpitations, weight loss, heat intolerance, tremor, and anxiety. There are several factors to consider; medically approved next steps include urgent care for red flags like chest pain or fainting, thyroid blood tests to confirm the diagnosis, and treatments like beta blockers, antithyroid drugs, radioactive iodine, or surgery depending on the cause. See the complete details below to understand what to do next and which options may fit your situation.
References:
* Vitti P, Rago T, Prete A, Vitti P. Hyperthyroidism: A Comprehensive Review of Clinical Manifestations, Diagnosis, and Treatment. J Clin Med. 2023 Mar 14;12(6):2272. doi: 10.3390/jcm12062272. PMID: 36983713; PMCID: PMC10057421.
* Prete A, Vitti P, Rago T, Vitti P. Cardiac Manifestations of Thyrotoxicosis: A Comprehensive Review. J Clin Med. 2022 Dec 21;12(1):37. doi: 10.3390/jcm12010037. PMID: 36614949; PMCID: PMC9782806.
* Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees MC, Samuels MA, Sosa MC, Stan MN, Swiglo DJ, Tabesh B, Taylor PN, Worden MC. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid. 2016 Oct;26(10):1343-1421. doi: 10.1089/thy.2016.0229. PMID: 27521074.
* Kahaly GJ, Diana T, Schreuers-Höck C, Dietlein M. Update on Management of Graves' Hyperthyroidism. J Clin Endocrinol Metab. 2021 Jan 1;106(1):54-61. doi: 10.1210/clinem/dgaa705. PMID: 33022718.
* Wiersinga WM. Graves' disease: then and now. Trends Endocrinol Metab. 2023 Jul;34(7):395-403. doi: 10.1016/j.tem.2023.04.004. PMID: 37173255.
Q.
Heart Racing? Why Your Internal Engine Is Stuck in Overdrive: Hyperthyroidism & Medical Next Steps
A.
A racing or pounding heart with tremors, weight loss, anxiety, heat intolerance, or sleep trouble can point to hyperthyroidism, a treatable condition where excess thyroid hormone puts your body in overdrive; diagnosis is by blood tests and treatments include antithyroid medication, radioactive iodine, or surgery, with beta blockers for symptom relief. There are several factors to consider that affect urgency and next steps, including heart rhythm risks and when to seek emergency care for chest pain, severe shortness of breath, fainting, or confusion. See below for the complete answer with what to ask your doctor, which tests confirm the cause, and how each treatment’s pros and cons could change your plan.
References:
* Osuna P, Dagan A, Kim JJ, Osorio Z, Abdo A, Alhamshari A, Samaan A, Abdel-Wahab O, Choksi R, O'Brien W. Cardiac manifestations of hyperthyroidism: a review. Front Endocrinol (Lausanne). 2024 Jan 11;14:1347094. doi: 10.3389/fendo.2023.1347094. PMID: 38249826; PMCID: PMC10804473.
* Chaker L, Cappola AR, Rodondi N, Schindhelm RK. Hyperthyroidism: an update. Lancet. 2023 May 13;401(10388):1609-1622. doi: 10.1016/S0140-6736(23)00392-4. PMID: 37172777.
* Smith TJ, Hegedüs L. Diagnosis and Management of Graves' Disease: A Review. JAMA. 2020 Nov 24;324(20):2088-2097. doi: 10.1001/jama.2020.17429. PMID: 33237190.
* Biondi B, Gribanov AV, Danilova TV, Gribanov AV, Nedoshivin AO. Cardiovascular effects of subclinical hyperthyroidism: Current perspectives. Thyroid. 2020 Aug;30(8):1089-1100. doi: 10.1089/thy.2019.0805. Epub 2020 Jul 16. PMID: 32672728.
* Klein I, Danzi K. Thyrotoxicosis and the Heart: An Update. Endocr Rev. 2018 Jun 1;39(3):351-370. doi: 10.1210/er.2017-00193. PMID: 29771146; PMCID: PMC6016629.
Q.
Hyperthyroidism in Women 30-45: Symptoms & Your Action Plan
A.
Hyperthyroidism is common and treatable in women 30 to 45; key signs include unexplained weight loss, rapid or irregular heartbeat, anxiety, tremor, heat intolerance, and menstrual changes that can affect fertility. Diagnosis is straightforward with TSH and free T4/T3 blood tests, and treatments include antithyroid medications, radioactive iodine, or surgery depending on the cause. There are several factors to consider, including Graves disease as a common cause, risks to your heart and bones, pregnancy and postpartum planning, and a step by step action plan for tracking symptoms, getting labs, and knowing when to seek urgent care; see the complete guidance below.
References:
* Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., ... & Luster, M. (2016). 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid, 26(10), 1343-1422.
* De Leo, S., Lee, S. Y., & Braverman, L. E. (2016). Hyperthyroidism. The Lancet, 388(10047), 906-918.
* Alexander, E. K., & Pearce, E. N. (2019). Thyroid function in women of reproductive age. Clinical Chemistry, 65(2), 195-201.
* Kahaly, G. J., Diana, T., & Glöckner, S. (2020). Management of Graves' Hyperthyroidism. The Journal of Clinical Endocrinology & Metabolism, 105(12), e4426-e4437.
* Pearce, S. H. S. (2021). Thyrotoxicosis. Medicine, 49(8), 534-539.
Q.
High or Low THS Test Results? Here’s What They Mean
A.
High TSH usually signals an underactive thyroid and low TSH suggests an overactive thyroid. Doctors interpret results with your symptoms and other labs like Free T4 and T3 because the typical range of about 0.4 to 4.0 mIU/L can vary with age, pregnancy, medications, and health conditions. There are several factors to consider, including subclinical results that may only need monitoring, common causes and treatments, when to repeat testing, and urgent warning signs like chest pain, severe weakness, or a very fast or irregular heartbeat that need prompt care. See complete details below to guide your next steps and what to discuss with your clinician.
References:
* Chaker L, Korevaar TIM, Medici M. Thyroid function tests: an update. StatPearls [Internet]. 2019 Feb 16. PMID: 30725916.
* Zaki S, Rizvi A. Thyroid-stimulating hormone: Clinical review. J Med Biochem. 2022 Aug 1;41(3):288-297. doi: 10.5937/jmb41-38294. PMID: 35911475; PMCID: PMC9332207.
* Li N, Xu K, Tian J, Li Z, Huang K. Management of subclinical hypothyroidism: an update. Front Endocrinol (Lausanne). 2023 Aug 4;14:1229712. doi: 10.3389/fendo.2023.1229712. PMID: 37601449; PMCID: PMC10436829.
* Yousuf M, Darbandi A, Ahmad J, Farhat F. Subclinical Hyperthyroidism: A Narrative Review of Diagnosis, Management, and Therapeutic Challenges. J Clin Med. 2023 Jun 20;12(13):4147. doi: 10.3390/jcm12134147. PMID: 37373800; PMCID: PMC10342939.
* Feldt-Rasmussen U, Klose M. Interpretation of Thyroid Function Tests. Clin Lab Med. 2018 Sep;38(3):335-345. doi: 10.1016/j.cll.2018.06.002. PMID: 30119854.
Q.
THS Test: What It Measures and Why Doctors Order It
A.
The TSH Thyroid Stimulating Hormone test measures the level of TSH in your blood to gauge thyroid function, with high TSH suggesting hypothyroidism and low TSH suggesting hyperthyroidism; doctors order it to investigate symptoms, screen at-risk people, and monitor treatment. Results are interpreted alongside your symptoms, history, and often free T4 or T3, and next steps may include repeating the test, additional labs, medication changes, or referral to an endocrinologist. There are several factors to consider for your situation, so see the complete details below to understand nuances that could affect your next steps.
References:
* Persani L. The role of TSH in the diagnosis and management of thyroid diseases. Eur J Endocrinol. 2017 Jul;177(1):R1-R15. PMID: 28381830.
* Garber JR, et al. Update on Thyroid Function Testing. Endocrinol Metab Clin North Am. 2016 Jun;45(2):269-82. PMID: 27241376.
* Zavalishina S, et al. TSH and thyroid disorders: a narrative review. Endocrine. 2023 Jul;81(1):21-30. PMID: 36720760.
* Spencer CA. Current Recommendations for Thyroid Function Testing. Clin Chem. 2019 Jul;65(7):813-821. PMID: 31085731.
* Baloch Z, et al. The Laboratory Assessment of Thyroid Function. Clin Lab Med. 2021 Mar;41(1):1-14. PMID: 33504505.
Q.
What is drisdol and is it safe to use?
A.
Drisdol is a prescription form of vitamin D2 (ergocalciferol) used to treat and prevent vitamin D deficiency, supporting healthy bones, calcium balance, and muscle function. It is generally safe when used as directed with medical oversight, but there are several factors to consider because excessive dosing can cause high calcium, kidney problems, and other side effects or drug interactions. For important details that could change your next steps such as who should be cautious, monitoring needs, and when to seek help, see below.
References:
Armas LA, Hollis BW, & Heaney RP. (2004). Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab, 15259406.
Arteh J, Narra S, & Nair S. (2009). Prevalence of vitamin D deficiency in chronic liver disease. Dig Dis Sci, 18657945.
Kamath PS, & Wiesner RH. (2001). A model to predict survival in patients with end-stage liver disease. Hepatology, 11157951.
Q.
What conditions make alkaline phosphatase low on lab tests?
A.
Low alkaline phosphatase can result from genetic hypophosphatasia; nutrient deficiencies (zinc, magnesium, protein); endocrine issues (hypothyroidism, poorly controlled diabetes); hematologic disorders (vitamin B12 deficiency, aplastic anemia); malabsorption (celiac/IBD); liver/metabolic disease (Wilson disease, severe fatty liver); severe illness or cachexia; medications/toxins (chemotherapy, corticosteroids, heavy metals); and even lab handling or assay errors. Mild reductions can be benign, but very low levels—especially with bone pain, fractures, jaundice, or persistent fatigue—warrant medical follow‑up; there are several factors to consider, and important testing and next steps are detailed below.
References:
Whyte MP. (2015). Hypophosphatasia: an overview of pathophysiology and… Endocr Rev, 26160765.
Castera L, Forns X, & Alberti A. (2005). Non-invasive evaluation of liver fibrosis using transient ela… J Hepatol, 15837386.
Shah AG, Lydecker A, Murray K, Tetri BN, Contos MJ, & Sanyal AJ. (2009). Comparison of noninvasive markers for hepatic fibrosis in pa… Hepatology, 19101537.
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees SA, Samuels M, Sosa JA, Stan MN, Walter MA. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid. 2016 Oct;26(10):1343-1421. doi: 10.1089/thy.2016.0229. Erratum in: Thyroid. 2017 Nov;27(11):1462. PMID: 27521067.
https://www.liebertpub.com/doi/10.1089/thy.2016.0229Sönmez E, Bulur O, Ertugrul DT, Sahin K, Beyan E, Dal K. Hyperthyroidism influences renal function. Endocrine. 2019 Jul;65(1):144-148. doi: 10.1007/s12020-019-01903-2. Epub 2019 Mar 23. PMID: 30904999.
https://link.springer.com/article/10.1007/s12020-019-01903-2Hyperthyroidism - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/hyperthyroidism/symptoms-causes/syc-20373659Doubleday AR, Sippel RS. Hyperthyroidism. Gland Surg. 2020 Feb;9(1):124-135. doi: 10.21037/gs.2019.11.01. PMID: 32206604; PMCID: PMC7082267.
https://pubmed.ncbi.nlm.nih.gov/32206604/