Hereditary Nephritis (Alport Syndrome) Quiz
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Blood in urine
Eye problems
Blood in pee
My eyesight is deteriorating
Hematuria
My eyesight is getting worse
Urine is red-brown
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What is Hereditary Nephritis (Alport Syndrome)?
A rare genetic disorder characterized by progressive kidney disease and abnormalities of the inner ear and the eye. It usually presents as blood in the urine, high blood pressure and swelling (edema).
Typical Symptoms of Hereditary Nephritis (Alport Syndrome)
- Blood in urine
- Swelling of the arms or hands
- Difficulty hearing in one or both ears
- Kidney failure on dialysis
- Vision problems
- Fever
- Facial swelling
- Family history of kidney disease
Diagnostic Questions for Hereditary Nephritis (Alport Syndrome)
Your doctor may ask these questions to check for this disease:
- Do you have blood in your urine?
- Are your hands or arms swollen?
- Are you experiencing difficulty hearing in one or both ears?
- Are you currently on dialysis?
- Are you experiencing any vision problems?
Treatment of Hereditary Nephritis (Alport Syndrome)
The treatment is directed toward the specific symptoms that are apparent in each individual. Angiotensin-converting enzyme (ACE inhibitor) therapy or angiotensin receptor blockers (ARB) therapy may reduce protein in urine and the progression of kidney disease.
Reviewed By:
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Apr 22, 2024
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Hereditary Nephritis (Alport Syndrome)?
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With a free 3-min Hereditary Nephritis (Alport Syndrome) quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.
This questionnaire is customized to your situation and symptoms, including the following personal information:
Biological Sex - helps us provide relevant suggestions for male vs. female conditions.
Age - adjusts our guidance based on any age-related health factors.
History - considers past illnesses, surgeries, family history, and lifestyle choices.
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- Gross hematuria
- Ear problems
- Abdominal pain
- Cloudy urine
- Hearing loss worse on the right
- Frequent urination
- Lower abdominal pain
- Hearing issues
- Foamy urine
- Blood clots in urine
- Hard of hearing in both ears but more on one side
- Burning sensation when urinating
- Bleeding from the urethra
- Hearing impairment
- Red brown urine
See full list
Symptoms Related to Hereditary Nephritis (Alport Syndrome)
Diseases Related to Hereditary Nephritis (Alport Syndrome)
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Which is the best Symptom Checker?
Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Kashtan CE. Alport Syndrome: Achieving Early Diagnosis and Treatment. Am J Kidney Dis. 2021 Feb;77(2):272-279. doi: 10.1053/j.ajkd.2020.03.026. Epub 2020 Jul 22. PMID: 32712016.
https://www.ajkd.org/article/S0272-6386(20)30734-4/fulltextNozu K, Nakanishi K, Abe Y, Udagawa T, Okada S, Okamoto T, Kaito H, Kanemoto K, Kobayashi A, Tanaka E, Tanaka K, Hama T, Fujimaru R, Miwa S, Yamamura T, Yamamura N, Horinouchi T, Minamikawa S, Nagata M, Iijima K. A review of clinical characteristics and genetic backgrounds in Alport syndrome. Clin Exp Nephrol. 2019 Feb;23(2):158-168. doi: 10.1007/s10157-018-1629-4. Epub 2018 Aug 20. PMID: 30128941; PMCID: PMC6510800.
https://link.springer.com/article/10.1007/s10157-018-1629-4Savige J, Ariani F, Mari F, Bruttini M, Renieri A, Gross O, Deltas C, Flinter F, Ding J, Gale DP, Nagel M, Yau M, Shagam L, Torra R, Ars E, Hoefele J, Garosi G, Storey H. Expert consensus guidelines for the genetic diagnosis of Alport syndrome. Pediatr Nephrol. 2019 Jul;34(7):1175-1189. doi: 10.1007/s00467-018-3985-4. Epub 2018 Jul 9. PMID: 29987460.
https://link.springer.com/article/10.1007/s00467-018-3985-4Torra R, Furlano M. New therapeutic options for Alport syndrome. Nephrol Dial Transplant. 2019 Aug 1;34(8):1272-1279. doi: 10.1093/ndt/gfz131. PMID: 31190059.
https://academic.oup.com/ndt/article/34/8/1272/5514265Watson S, Padala SA, Hashmi MF, et al. Alport Syndrome. [Updated 2023 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470419/
https://www.ncbi.nlm.nih.gov/books/NBK470419/#:~:text=Alport%20syndrome%20is%20a%20genetic,hematuria%2C%20edema%2C%20and%20hypertension.