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What is Amyloidosis?

A disease in which "amyloid," an abnormal type of protein, accumulates in various organs, causing damage. Affected areas can include the heart, kidneys, and gastrointestinal tract. The causes are diverse.

Typical Symptoms of Amyloidosis

Diagnostic Questions for Amyloidosis

Your doctor may ask these questions to check for this disease:

  • Do you have pain all over your body?
  • Do you have frequent stomach or abdominal pain with unknown causes?
  • Have you noticed any blood in your stool?
  • Do you experience wheezing or whistling sounds when breathing?
  • Do you experience numbness in your fingers?

Treatment of Amyloidosis

There is currently no cure for amyloidosis, so treatment focuses on slowing the disease and managing symptoms. As organs become damaged, treatments like dialysis or organ transplants may be needed.

Reviewed By:

Caroline M. Doan, DO

Caroline M. Doan, DO (Internal Medicine)

Dr. Doan received a Bachelor of Science degree with honors from UCLA. Prior to obtaining her medical degree, she was involved in oncology clinical research at City of Hope, a National Cancer Institute-designated comprehensive cancer center in southern California. She attended medical school at Touro University California, and completed her residency in Internal Medicine at Oregon Health & Science University. She is certified by the American Board of Internal Medicine and holds an active medical license in several states. She currently works as a physician for Signify Health providing home-based health care.

Yoshinori Abe, MD

Yoshinori Abe, MD (Internal Medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

From our team of 50+ doctors

Content updated on Mar 31, 2024

Following the Medical Content Editorial Policy

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How Ubie Can Help You

With a free 3-min Amyloidosis quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.

This questionnaire is customized to your situation and symptoms, including the following personal information:

  • Biological Sex - helps us provide relevant suggestions for male vs. female conditions.

  • Age - adjusts our guidance based on any age-related health factors.

  • History - considers past illnesses, surgeries, family history, and lifestyle choices.

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People with similar symptoms also use Ubie's symptom checker to find possible causes

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Symptoms Related to Amyloidosis

Diseases Related to Amyloidosis

FAQs

Q.

Amyloidosis in Women 65+: Early Signs You Shouldn’t Ignore

A.

Early signs in women 65+ can include persistent fatigue and unexplained weight loss. Also watch for shortness of breath, leg or ankle swelling, irregular heartbeat, foamy urine or puffiness around the eyes, numbness or tingling or new carpal tunnel in both hands, digestive changes, easy bruising, or an enlarged tongue, especially when several occur together. There are several factors to consider, and early evaluation can protect the heart, kidneys, and nerves; see below for the full list of red flags, what makes amyloidosis easy to miss, how it is diagnosed, when to seek urgent care, and practical next steps to take with your doctor.

References:

* Stone JR, Pahuja M, Ajithkumar A, Nattel M, Naim N, Sherif S, Dubin R, Bokhari S. Recognizing Transthyretin Amyloid Cardiomyopathy in Women: An Underdiagnosed and Underrepresented Population. J Card Fail. 2022 May;28(5):811-820. PMID: 34793910.

* D'Souza R, Dweck MR, Dungu JN, Dronamraju N, Garg P, Harkness A, Lachmann H, Lattimore G, Martinez-Naharro A, Whelan CJ, Wechalekar AD, Gillmore JD, Fontana M, Huttin O. Sex-Specific Differences in Clinical Presentation and Outcomes in Transthyretin Amyloid Cardiomyopathy. Circulation. 2021 May 11;143(19):1889-1899. PMID: 33596660.

* García-Pavía P, García-González C, García-Ortiz A, De Teresa E, Mazón P, Barrientos-Parejo N, Lara-Padrón A, de la Fuente-Fernández A, Ortiz-Fernández R, Martínez-Naharro A, De la Espriella R, Fontana M. Sex-related differences in amyloid cardiomyopathy due to transthyretin. Eur J Heart Fail. 2020 Dec;22(12):2249-2258. PMID: 32662283.

* D'Souza R, D'Souza S, Nordin S, Dungu JN. Prevalence of wild-type transthyretin amyloidosis in older patients with heart failure with preserved ejection fraction: a systematic review and meta-analysis. J Am Geriatr Soc. 2021 Jun;69(6):1604-1617. PMID: 33611728.

* Gertz MA. Amyloid light-chain amyloidosis: an update. Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):640-646. PMID: 34882046.

See more on Doctor's Note

Ubie is supervised by 50+ medical experts worldwide

Our symptom checker AI is continuously refined with input from experienced physicians, empowering them to make more accurate diagnoses.

Maxwell J. Nanes, DO

Maxwell J. Nanes, DO

Emergency Medicine

Waukesha Memorial Hospital, Waukesha Wisconsin, USA

Caroline M. Doan, DO

Caroline M. Doan, DO

Internal Medicine

Signify Health

Benjamin Kummer, MD

Benjamin Kummer, MD

Neurology, Clinical Informatics

Icahn School of Medicine at Mount Sinai

Charles Carlson, DO, MS

Charles Carlson, DO, MS

Psychiatry

U.S. Department of Veterans Affairs

Dale Mueller, MD

Dale Mueller, MD

Cardiothoracic and Vascular Surgery

Cardiothoracic and Vascular Surgery Associates

Ravi P. Chokshi, MD

Ravi P. Chokshi, MD

Obstetrics and gynecology

Penn State Health

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Which is the best Symptom Checker?

Which is the best Symptom Checker?

Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.

Link to full study:

https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1

References