Cervical Cancer Quiz

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What is Cervical Cancer?

Cancer of the cervix (entrance to the womb) or uterus. Risk factors include infection with viruses (HPV, HIV), smoking, and age. Regular Pap smear testing is recommended for women of childbearing age for early detection.

Typical Symptoms of Cervical Cancer

Diagnostic Questions for Cervical Cancer

Your doctor may ask these questions to check for this disease:

  • Have you ever had any abnormality on cervical cancer screening?
  • Have you experienced any vaginal bleeding or unusual discharge outside of your period?
  • Do your periods last more than 8 days?
  • Are you experiencing pain in the pelvis?
  • Have you noticed any changes in the color, amount, or odor of your vaginal discharge?

Treatment of Cervical Cancer

A gynecologist confirms the diagnosis with a "cervical biopsy" and may want to assess whether the cancer has spread with CT scans or MRIs. Once all that information is gathered they then recommend a treatment plan. Options depend on factors like the extent of disease and can include surgery, internal or external radiation, or chemotherapy.

Reviewed By:

Robin Schoenthaler, MD

Robin Schoenthaler, MD (Oncology)

Board certified radiation oncologist with over 30 years experience treating cancer patients. Senior physician advisor for expert medical options in adult oncology. Published award-winning essayist on medical and health issues and more.

Seiji Kanazawa, MD, PHD

Seiji Kanazawa, MD, PHD (Obstetrics and Gynecology (OBGYN))

Dr. Kanazawa graduated from the Niigata University Faculty of Medicine and received his Ph.D. from the Tohoku University Graduate School of Medicine. He is working on the front line of the General Perinatal Center, including the Tokyo Tama General Medical Center and the National Center for Research in Fertility Medicine, where he provides maternal and fetal care and undertakes clinical research. At Ubie, Dr. Kanazawa has been designing the Ubie AI Symptom Checker and has taken on the role of general obstetrics and gynecology consultation at FMC Tokyo Clinic by providing fetal ultrasound and prenatal consultation.

From our team of 50+ doctors

Content updated on Mar 31, 2024

Following the Medical Content Editorial Policy

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How Ubie Can Help You

With a free 3-min Cervical Cancer quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.

This questionnaire is customized to your situation and symptoms, including the following personal information:

  • Biological Sex - helps us provide relevant suggestions for male vs. female conditions.

  • Age - adjusts our guidance based on any age-related health factors.

  • History - considers past illnesses, surgeries, family history, and lifestyle choices.

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Symptoms Related to Cervical Cancer

Diseases Related to Cervical Cancer

FAQs

Q.

Are there side effects from the HPV vaccine?

A.

Yes, side effects can occur; most are mild and short-lived, such as pain, redness or swelling where the shot is given, low fever, headache, fatigue, dizziness, nausea, and occasional muscle or joint aches or fainting in teens. Serious reactions are very rare, and large studies show no increased risk of autoimmune, neurological, or blood clot disorders, though severe allergic reactions can happen. There are several factors to consider; see below for key details on symptom management, warning signs, and when to seek medical care.

References:

Arnheim-Dahlström L, Pasternak B, Svanström H, et al. (2013). Autoimmune, neurological, and venous thromboembolic adverse events after… BMJ, 23599958.

https://pubmed.ncbi.nlm.nih.gov/23599958/

Gee J, Naleway AL, Shui I, et al. (2014). Postlicensure safety surveillance for quadrivalent human papillomavirus… Pediatrics, 23340801.

https://pubmed.ncbi.nlm.nih.gov/23340801/

Castera L, Vergniol J, Foucher J, et al. (2005). Prospective comparison of transient elastography, FibroTest, APRI, and liver biopsy… Gastroenterology, 15831999.

https://pubmed.ncbi.nlm.nih.gov/15831999/

See more on Doctor's Note

Q.

Are there support groups or organizations for people with cervical cancer?

A.

Yes. National, online, and local options exist, including the American Cancer Society, CancerCare, the National Cervical Cancer Coalition, SHARE, Cancer Support Community, Gilda’s Club, hospital-based programs, and global groups like WCCAN and the European Cervical Cancer Association, plus active communities on Facebook, Reddit, and Inspire. There are several factors to consider, from counseling and peer groups to rides and financial aid; see below for helplines, links, and how to find the right fit and next steps with your care team.

References:

Anderson B, Rankin A, & Keefe FJ. (2008). Identifying and addressing the psychosocial needs of patients with gynecologic… Journal of Supportive Oncology, 18085579.

https://pubmed.ncbi.nlm.nih.gov/18085579/

Friedrich-Rust M, Nierhoff J, & Herrmann E. (2010). Accuracy of transient elastography for the staging of liver fibrosis: a… American Journal of Gastroenterology, 21756337.

https://pubmed.ncbi.nlm.nih.gov/21756337/

D’Amico G, Garcia-Tsao G, & Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrhosis: a… Journal of Hepatology, 16423510.

https://pubmed.ncbi.nlm.nih.gov/16423510/

See more on Doctor's Note

Q.

At what age should you start cervical cancer screening?

A.

Start cervical cancer screening at age 21, regardless of sexual activity. From 21 to 29, get a Pap test every 3 years; from 30 to 65, choose Pap every 3 years or co-testing with HPV every 5 years, with stopping possible after 65 if prior results are adequately negative. There are several factors to consider, including exceptions for certain medical histories, so see the complete answer below for key details and the right next steps.

References:

US Preventive Services Task Force. (2018). Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement. JAMA, 29371399.

https://pubmed.ncbi.nlm.nih.gov/29371399/

American College of Obstetricians and Gynecologists. (2018). Practice Bulletin No. 168: Cervical Cancer Screening and Prevention. Obstet Gynecol, 29270130.

https://pubmed.ncbi.nlm.nih.gov/29270130/

European Association for the Study of the Liver & Asociacion Latinoamericana para el Estudio del Higado. (2015). EASL-ALEH clinical practice guidelines: Non-invasive tests for evaluation of liver fibrosis and cirrhosis. Journal of Hepatology, 25634546.

https://pubmed.ncbi.nlm.nih.gov/25634546/

See more on Doctor's Note

Q.

Can cervical cancer come back after treatment?

A.

Yes, cervical cancer can come back after treatment; about 10 to 15 percent of early-stage cases and 30 to 50 percent of locally advanced cases recur, most often within 2 to 3 years, with risk shaped by stage, tumor size, lymph nodes, and response to therapy. There are several important details to consider, including warning symptoms, recommended follow-up timing, and treatment options if it returns; see the complete guidance below to help plan your next steps.

References:

National Comprehensive Cancer Network. (2019). NCCN Guidelines Insights: Cervical Cancer, version… J Natl Compr Canc Netw, 30301333.

https://pubmed.ncbi.nlm.nih.gov/30301333/

Sandrin L, Fourquet B, Hasquenoph JM, et al. (2003). Transient elastography: a new noninvasive… Ultrasound Med Biol, 14698221.

https://pubmed.ncbi.nlm.nih.gov/14698221/

Kim WR, Biggins SW, Kremers WK, et al. (2008). Hyponatremia and mortality among… N Engl J Med, 18605164.

https://pubmed.ncbi.nlm.nih.gov/18605164/

See more on Doctor's Note

Q.

Can cervical cancer occur without HPV infection?

A.

Almost all cervical cancers are caused by high-risk HPV, with studies finding HPV in more than 99% of tumors; truly HPV-negative cases are exceptional. Apparent HPV-negative results often reflect testing limits, and a few rare non-HPV pathways exist, so there are important nuances that can affect screening, vaccination, and when to seek care. See below for complete details.

References:

Serrano B, de Sanjosé S, Tous S, et al. (2007). Attribution of human papillomavirus genotypes in invasive cervical… Lancet Oncology, 17934432.

https://pubmed.ncbi.nlm.nih.gov/17934432/

Munk C, Kjaer SK, Hammer A, et al. (2014). Human papillomavirus prevalence and genotype distribution in cervical carcinoma in… Int J Cancer, 23740739.

https://pubmed.ncbi.nlm.nih.gov/23740739/

D’Amico G, Garcia-Tsao G, Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrhosis… Journal of Hepatology, 16503314.

https://pubmed.ncbi.nlm.nih.gov/16503314/

See more on Doctor's Note

Q.

Can someone who has never had sex still get cervical cancer?

A.

It is extremely unlikely, but not impossible. Cervical cancer almost always requires persistent high-risk HPV that is typically spread through sexual contact, yet rare nonsexual routes like mother-to-baby transmission or self-transfer can occur. There are several factors to consider for prevention and early detection, including vaccination and routine screening starting at age 21, as well as symptoms that need prompt evaluation; see below for details that can guide your next steps.

References:

Huang YH, Chen J, Zhao Y, Sun CA, Hong CM, Liu TJ. (2013). Vertical transmission of human papillomavirus: a systematic… BJOG: An International Journal of Obstetrics and Gynaecology, 23560789.

https://pubmed.ncbi.nlm.nih.gov/23560789/

Tsochatzis EA, Bosch J, Burroughs AK. (2014). Liver cirrhosis. Lancet, 24309431.

https://pubmed.ncbi.nlm.nih.gov/24309431/

Castera L, Forns X, Alberti A. (2008). Non-invasive evaluation of liver fibrosis using transient… Journal of Hepatology, 18318512.

https://pubmed.ncbi.nlm.nih.gov/18318512/

See more on Doctor's Note

Q.

Can you get pregnant after cervical cancer treatment?

A.

Yes, pregnancy is possible after some early cervical cancer treatments, especially cone biopsy or radical trachelectomy. About half who try after trachelectomy conceive and most pregnancies lead to live births, though preterm delivery is more common. There are several factors to consider, including cancer stage, treatment type, when it is safe to try again, and the need for high-risk obstetric care, while hysterectomy or chemoradiation usually end natural fertility. See below for key details and options that could affect your next steps.

References:

Li J, Li JJ, Liu Y, Gao Y, & Zhong XY. (2014). Pregnancy outcomes after radical trachelectomy for early-stage cervical… Int J Gynecol Cancer, 24246121.

https://pubmed.ncbi.nlm.nih.gov/24246121/

Bentivegna E, Ruscito I, Magné N, Castelnau-Marchand P, & Morice P. (2016). Oncological and obstetrical outcomes after fertility-sparing… Gynecol Oncol, 28755718.

https://pubmed.ncbi.nlm.nih.gov/28755718/

American Association for the Study of Liver Diseases. (2018). AASLD practice guidance on the management of decompensated… Hepatology, 30322807.

https://pubmed.ncbi.nlm.nih.gov/30322807/

See more on Doctor's Note

Q.

Do all cervical cancer patients need chemotherapy?

A.

Not all cervical cancer patients need chemotherapy; treatment depends on the cancer’s stage, specific surgical findings, and whether it has spread. Chemo is standard with radiation for locally advanced disease, for high-risk findings after surgery, for some intermediate-risk features with radiation, and for recurrent or metastatic cases, while many very early-stage tumors without added risk factors can avoid it. There are several factors to consider; see below to understand more and to plan next steps with a gynecologic oncologist.

References:

Keys HM, Bundy BN, Stehman FB, Muderspach LI, Clark RM, Fowler WC Jr., Homesley HD, Creasman WT, Insalaco S. (1999). Cisplatin, radiation, and adjuvant hysterectomy compared with… N Engl J Med, 10024110.

https://pubmed.ncbi.nlm.nih.gov/10024110/

Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration. (2008). Reducing uncertainties about the effects of chemoradiotherapy fo… J Clin Oncol, 18235145.

https://pubmed.ncbi.nlm.nih.gov/18235145/

D'Amico G, Garcia-Tsao G, Pagliaro L. (2006). Natural history and prognostic indicators of survival in… J Hepatol, 16488457.

https://pubmed.ncbi.nlm.nih.gov/16488457/

See more on Doctor's Note

Q.

Do lifestyle or sexual activity affect cervical cancer risk?

A.

Yes: sexual behaviors that increase exposure to high-risk HPV, including early first sex, multiple partners for you or your partner, and inconsistent condom use, raise cervical cancer risk; consistent condom use reduces but does not eliminate risk, and mutual monogamy plus HPV vaccination help lower it. Lifestyle also matters, with smoking clearly increasing risk, and factors like long-term birth control pill use, immunosuppression, poor diet, and obesity modestly adding risk, while staying up to date on Pap and HPV screening sharply reduces it. There are several factors to consider and important steps you can take; see the complete guidance below to understand key nuances, timelines for risk reduction, and which next actions to discuss with your doctor.

References:

Rodriguez AC, Schiffman M, Herrero R, Hildesheim A, Porras C, Wacholder S, Solomon D, Castle P, & Burk RD. (2008). Long-term risk of cervical cancer in relation to smoking. Journal of the National Cancer Institute, 100(10), 696–703. 18483271.

https://pubmed.ncbi.nlm.nih.gov/18483271/

Winer RL, Hughes JP, Feng Q, O’Reilly S, Lee SK, Kiviat NB, Holmes KK, & Koutsky LA. (2006). Condom use and the risk of genital HPV infection in young women. Journal of Infectious Diseases, 193(5), 728–736. 16342821.

https://pubmed.ncbi.nlm.nih.gov/16342821/

Parkes J, Guha IN, Roderick P, Harris S, Tsochatzis E, Ribeiro A, Fraser A, & Hudson M. (2010). Enhanced liver fibrosis test can predict clinical outcome in patients with chronic liver disease. Gut, 59(9), 1245–1251. 20430885.

https://pubmed.ncbi.nlm.nih.gov/20430885/

See more on Doctor's Note

Q.

Does CIN mean a precancerous condition, and how is it different from cancer?

A.

Yes. CIN is a precancerous change in the surface layer of the cervix, graded 1 to 3; unlike cancer, it has not invaded deeper tissues or spread, and while many CIN 1 lesions regress, higher grades carry a greater risk of progression. There are several factors to consider for monitoring and treatment choices; see below for key differences, risks by grade, and next steps for screening and care.

References:

Ostör AG. (1993). Natural history of cervical intraepithelial neoplasia: a criti… Int J Gynecol Pathol, 8248340.

https://pubmed.ncbi.nlm.nih.gov/8248340/

Massad LS, Einstein MH, Huh WK, et al. (2012). 2012 updated consensus guidelines for the management of abno… Obstet Gynecol, 22573896.

https://pubmed.ncbi.nlm.nih.gov/22573896/

D’Amico G, Garcia-Tsao G, & Pagliaro L. (2006). Natural history and prognostic ind… J Hepatol, 16469609.

https://pubmed.ncbi.nlm.nih.gov/16469609/

See more on Doctor's Note

Q.

Does using condoms completely prevent HPV infection?

A.

Condoms significantly lower the risk of HPV but do not completely prevent it, because HPV spreads through skin-to-skin contact on areas a condom does not cover; consistent use has been shown to cut new infections by about 50 to 70% and reduce how long infections persist. There are several factors to consider. See below for steps to maximize protection, including vaccination, correct condom use every time, and appropriate screening.

References:

Winer RL, Hughes JP, Feng Q, O’Reilly SF, Kiviat NB, Holmes KK, & Koutsky LA. (2006). Condom use and the risk of genital human papillomavirus infect… J Infect Dis, 17058206.

https://pubmed.ncbi.nlm.nih.gov/17058206/

Kjaer SK, van den Brule AJ, Paull G, Svare EI, Sherman ME, Thomsen BL, Meijer CJ, Wojcik M, & Nygard M. (1994). Acquisition and persistence of human papillomavirus infectio… BMJ, 7948170.

https://pubmed.ncbi.nlm.nih.gov/7948170/

Kamath PS, & Wiesner RH. (2001). A model to predict survival in patients with end-stage liver diseas… Hepatology, 11157951.

https://pubmed.ncbi.nlm.nih.gov/11157951/

See more on Doctor's Note

Q.

Is cervical cancer curable if detected early?

A.

Yes, early cervical cancer is often curable, with cure and five-year survival rates commonly above 90% for Stage IA to IB1 when the disease is confined to the cervix and treated promptly. There are several factors to consider, including stage, tumor size, lymph nodes, treatment choice, and follow-up; see below for key details that can guide your next steps, from screening and HPV vaccination to fertility-sparing options and when to seek prompt care.

References:

Delgado G, Bundy BN, Zaino RJ, Sevin BU, Creasman WT, & Major F. (1990). Prospective surgical-pathologic study of disease-free interval… Am J Obstet Gynecol, 2389974.

https://pubmed.ncbi.nlm.nih.gov/2389974/

Sankaranarayanan R, Budukh A, & Rajkumar R. (2001). Effective screening programmes for cervical cancer in low-and middle-income developing… Bull World Health Organ, 11429279.

https://pubmed.ncbi.nlm.nih.gov/11429279/

Tsochatzis EA, Bosch J, & Burroughs AK. (2014). Liver stiffness predicts risk of decompensation, hepatocellular… J Hepatol, 24332403.

https://pubmed.ncbi.nlm.nih.gov/24332403/

See more on Doctor's Note

Q.

What happens after you are diagnosed with cervical cancer?

A.

After diagnosis, your team confirms the cancer type and stage with biopsy review, imaging, and a pelvic exam, then a multidisciplinary group tailors a plan to your health goals and fertility preferences. Depending on stage, care may involve fertility-sparing surgery or hysterectomy, chemoradiation with brachytherapy, or systemic and palliative treatments, along with side effect management and regular follow-up. There are several factors to consider that can affect your next steps, so see the complete step-by-step details below.

References:

Pecorelli S. (2019). Revised FIGO staging for carcinoma of the cervix uteri. Int J Gynaecol Obstet, 145(1):129-135. 31049519.

https://pubmed.ncbi.nlm.nih.gov/31049519/

Colombo N, Creutzberg C, Amant F, et al. (2017). Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol, 28(suppl_4):iv72-iv83. 28674537.

https://pubmed.ncbi.nlm.nih.gov/28674537/

European Association for the Study of the Liver. (2018). EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol, 69(2):406-460. 30079137.

https://pubmed.ncbi.nlm.nih.gov/30079137/

See more on Doctor's Note

Q.

What is the difference between cervical cancer and endometrial cancer?

A.

Cervical cancer starts in the cervix, is most often caused by high-risk HPV, tends to affect women in their 30s to 40s, and is detected by Pap and HPV tests. Endometrial cancer starts in the uterine lining, is linked to unopposed estrogen and obesity, is most common after menopause, lacks routine screening, and often causes postmenopausal bleeding. There are several factors to consider. Treatments, prognosis, and the right next steps vary by symptoms and risk. See below for key details that can guide screening, diagnosis, prevention, and when to see a doctor.

References:

Trask DK, Reyes C, DeLair DF, Soslow RA, Park KJ. (2018). Immunohistochemical distinction of primary cervical and endometrial adenocarcinomas… Am J Surg Pathol, 29892314.

https://pubmed.ncbi.nlm.nih.gov/29892314/

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide… CA Cancer J Clin, 33388603.

https://pubmed.ncbi.nlm.nih.gov/33388603/

Singh S, Khera R, Allen AM, Montero I, Murad MH. (2013). Liver stiffness is associated with risk of decompensation, liver cancer, and death in patients with chronic liver diseases… Clin Gastroenterol Hepatol, 23423761.

https://pubmed.ncbi.nlm.nih.gov/23423761/

See more on Doctor's Note

Q.

What is the difference between people who need chemotherapy and those who only need surgery for cervical cancer?

A.

Surgery only is typically for very early-stage cervical cancer confined to the cervix, generally stage IA1 to selected IB1, with tumors 2 cm or smaller, no lymph node spread, and clear margins; chemotherapy, usually with radiation, is used when tumors are larger, nodes are positive, there is parametrial spread or involved margins, stages IB2 to IVA, or any distant metastasis. There are several factors to consider. See below to understand more, including how exact staging, imaging, pathology, and your goals can affect side effects, recovery, fertility options, and your next steps.

References:

Bhatla N, Aoki D, Sharma DN, & Sankaranarayanan R. (2018). Cancer of the cervix uteri. Int J Gynaecol Obstet, 30170307.

https://pubmed.ncbi.nlm.nih.gov/30170307/

Cibula D, Pötter R, Planchamp F, et al. (2019). ESGO/ESTRO/ESP guidelines for the management of patients wi… Int J Gynaecol Cancer, 31007615.

https://pubmed.ncbi.nlm.nih.gov/31007615/

Tsochatzis EA, Bosch J, & Burroughs AK. (2014). Liver cirrhosis. Lancet, 24388029.

https://pubmed.ncbi.nlm.nih.gov/24388029/

See more on Doctor's Note

Q.

What side effects can occur with chemotherapy for cervical cancer?

A.

Common side effects of cervical cancer chemotherapy include fatigue; blood count problems such as anemia, infection risk from low white cells, and easy bruising; nausea, vomiting, diarrhea or constipation; mouth sores; hair loss or skin changes; nerve tingling or numbness; and drug specific kidney or hearing problems. Allergic reactions, blood sugar and memory or concentration changes can occur, and there are rare long term risks to bones, heart, or secondary cancers; seek urgent care for fever of 38 C or higher, severe vomiting or diarrhea, or uncontrolled bleeding. There are several factors to consider and proven ways to prevent or manage these effects, so see below for the complete list, warning signs, and next steps to review with your care team.

References:

Holloway RW, Rosenberg ES, Khalique MR, Schefter TE, & Klopp AH. (2015). Acute haematologic toxicities and outcomes among cervical cancer patients… Radiother Oncol, 26209823.

https://pubmed.ncbi.nlm.nih.gov/26209823/

Castera L, Forns X, & Alberti A. (2008). Non-invasive evaluation of liver fibrosis using transient… Journal of Hepatology, 18479776.

https://pubmed.ncbi.nlm.nih.gov/18479776/

D'Amico G, Garcia-Tsao G, & Pagliaro L. (2006). Natural history and prognostic indicators of survival in… Journal of Hepatology, 16963482.

https://pubmed.ncbi.nlm.nih.gov/16963482/

See more on Doctor's Note

Q.

When is it safe to resume sexual activity after cervical cancer surgery?

A.

Timelines vary by procedure: about 4 to 6 weeks after a cone biopsy or simple trachelectomy, 6 to 8 weeks after a simple hysterectomy, 8 to 12 weeks or longer after a radical hysterectomy, and often 3 to 6 months if you had pelvic radiation. For safety, wait until your follow-up exam confirms complete healing and bleeding or discharge has stopped, since treatments, health, and symptoms can change the plan; there are several factors to consider, with important signs to watch for and comfort tips listed below.

References:

Bergmark K, Avall-Lundqvist E, Dickman PW, Henningsohn L, Steineck G. (1999). Vaginal changes and sexuality in women with a history of ce… New England Journal of Medicine, 10364558.

https://pubmed.ncbi.nlm.nih.gov/10364558/

Song YS, Kim JH. (2012). Sexual function after radical versus simple hysterectomy in ea… International Journal of Gynecological Cancer, 22423077.

https://pubmed.ncbi.nlm.nih.gov/22423077/

D'Amico G, Garcia-Tsao G, Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrhosis… Hepatology, 16447203.

https://pubmed.ncbi.nlm.nih.gov/16447203/

See more on Doctor's Note

Q.

Can changes in vaginal discharge be a symptom for cervical cancer?

A.

Yes, changes in vaginal discharge can sometimes signal cervical disease, including cervical cancer, though most discharge changes are benign. Patterns that warrant prompt medical evaluation include watery or blood-tinged discharge, a strong foul odor, or a persistent increase, especially if accompanied by spotting after sex, abnormal bleeding, pelvic pain, or symptoms after menopause. There are several factors to consider. See below for what is normal vs not, when to seek care, and the role of Pap and HPV testing, vaccination, and other next steps.

References:

Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F. (2020). Cervical cancer: epidemiology, risk factors, pathogenesis… Nat Rev Dis Primers, 31915340.

https://pubmed.ncbi.nlm.nih.gov/31915340/

Kim BK, Kim DY, Park JY, et al. (2013). Diagnostic accuracy of transient elastography for predicting cirrhosis… J Viral Hepat, 22955138.

https://pubmed.ncbi.nlm.nih.gov/22955138/

European Association for the Study of the Liver. (2018). EASL clinical practice guidelines for the management… Journal of Hepatology, 29362307.

https://pubmed.ncbi.nlm.nih.gov/29362307/

See more on Doctor's Note

Q.

Can pelvic or lower back pain be related to cervical cancer?

A.

Pelvic or lower back pain is common and usually due to benign causes, but it can rarely be linked to advanced cervical cancer, especially if the pain is persistent or worsening, wakes you at night, is not relieved by rest or over-the-counter medicine, or is accompanied by abnormal vaginal bleeding or discharge, weight loss, fever, or leg numbness or weakness. There are several factors to consider; see below for the full list of red flags, how cervical cancer can cause pain (tumor pressure and spread to pelvic and lumbar bones), and the best next steps, including when to see a doctor right away.

References:

Yoshikawa K, & Saito T. (2006). Bone metastases from cervical carcinoma: retrospective analysis of 109 patients. Gynecologic Oncology, 16448526.

https://pubmed.ncbi.nlm.nih.gov/16448526/

Stefanescu H, & Iacob S. (2017). Liver stiffness measurement predicts decompensation in patients with compensated… Journal of Hepatology, 28621350.

https://pubmed.ncbi.nlm.nih.gov/28621350/

Castera L, & Forns X. (2008). Prospective comparison of transient elastography and biomarkers in the assessment… Journal of Hepatology, 18760759.

https://pubmed.ncbi.nlm.nih.gov/18760759/

See more on Doctor's Note

Q.

Can the HPV vaccine prevent cervical cancer?

A.

Yes, the HPV vaccine greatly reduces the risk of cervical cancer by blocking infection with the highest-risk HPV types, especially 16 and 18, which has led to large drops in precancerous cervical lesions where vaccination rates are high. It works best when given before exposure, but catch-up vaccination and routine cervical screening remain important since the vaccine does not prevent all cancer-causing HPV types. There are several factors to consider, including recommended ages, dosing, safety, and how vaccination pairs with screening; see below for details that can guide your next steps.

References:

Paavonen J, Naud P, Salmerón J, et al. (2009). Efficacy of human papillomavirus-16/18 AS04-adjuvanted vaccine in… N Engl J Med, 19349346.

https://pubmed.ncbi.nlm.nih.gov/19349346/

Yin M, Talwalkar JA, Glaser KJ, et al. (2010). Noninvasive assessment of hepatic fibrosis by… Radiology, 20495809.

https://pubmed.ncbi.nlm.nih.gov/20495809/

European Association for the Study of the Liver. (2014). EASL clinical practice guidelines for the management of patients with decompensated cirrhosis. Journal of Hepatology, 24986678.

https://pubmed.ncbi.nlm.nih.gov/24986678/

See more on Doctor's Note

Q.

Does abnormal bleeding from cervical cancer have a specific color or smell?

A.

There is no single specific color or smell; abnormal bleeding can be bright red, dark red or brown, or light pink and may be watery or mucus-tinged, and odor can be absent or occasionally foul or fishy if there is tissue breakdown or infection. There are several factors to consider; see below to understand more, including when to seek care. Seek prompt medical attention for a strong unusual odor, bleeding between periods or after sex, heavier or longer bleeding than usual, or any bleeding after menopause.

References:

American College of Obstetricians and Gynecologists. (2012). ACOG Practice Bulletin No. 128: Diagnosis and management of abnormal uterine bleeding in reproductively-aged women… Obstet Gynecol, 22717636.

https://pubmed.ncbi.nlm.nih.gov/22717636/

Biggins SW, Kim WR, Terrault NA, & Patel AA. (2006). Evidence-based incorporation of serum sodium concentration into the model for end-stage liver disease… Gastroenterology, 16427317.

https://pubmed.ncbi.nlm.nih.gov/16427317/

Tsochatzis EA, Bosch J, & Burroughs AK. (2014). Liver cirrhosis… Lancet, 24461554.

https://pubmed.ncbi.nlm.nih.gov/24461554/

See more on Doctor's Note

Q.

How common is cervical cancer?

A.

Cervical cancer is common worldwide, with about 604,000 new cases and 342,000 deaths in 2020, making it the fourth most frequent cancer in women; in the U.S., it causes roughly 14,100 new cases and 4,280 deaths each year. Rates vary widely by region and can drop with HPV vaccination and screening, and there are several factors and next steps to consider for your situation. See the complete details below.

References:

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A & Bray F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence… CA Cancer J Clin, 33538338.

https://pubmed.ncbi.nlm.nih.gov/33538338/

D’Amico G, Garcia-Tsao G & Pagliaro L. (2006). Natural history and prognostic indicators of survival in… Semin Liver Dis, 16501105.

https://pubmed.ncbi.nlm.nih.gov/16501105/

Berzigotti A, Abraldes JG, Arena U, et al. (2013). Non-invasive evaluation of portal hypertension using transient… J Hepatol, 23415617.

https://pubmed.ncbi.nlm.nih.gov/23415617/

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Q.

How often should you get screened for cervical cancer?

A.

Start screening at 21; ages 21 to 29 get a Pap test every 3 years; ages 30 to 65 choose HPV testing every 5 years, Pap every 3 years, or both tests together every 5 years, with co-testing preferred. You can stop after 65 if you have had adequate negative prior screening or after a total hysterectomy for noncancer reasons, but people with a history of high grade precancer, cancer, or who are immunocompromised need different plans. There are several factors to consider that may change your timing and follow up; see below for the complete guidance.

References:

Saslow D, & Solomon D. (2018). Cervical cancer screening for individuals at average risk: 2018 Guideline… CA Cancer J Clin, 29450739.

https://pubmed.ncbi.nlm.nih.gov/29450739/

Moyer VA. (2012). Screening for cervical cancer: U.S. Preventive Services Task Force recommendation… JAMA, 22346696.

https://pubmed.ncbi.nlm.nih.gov/22346696/

Thiele M, Nøjgaard C, Møller S, & Krag A. (2019). Liver stiffness predicts decompensation in patients with compensated cirrhosis… J Hepatol, 31198956.

https://pubmed.ncbi.nlm.nih.gov/31198956/

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Q.

Is abnormal vaginal bleeding a sign of cervical cancer?

A.

Abnormal vaginal bleeding can be a sign of cervical cancer, especially bleeding after sex, any bleeding after menopause, or bleeding between periods, though most abnormal bleeding has other causes. There are several factors to consider; see below for which patterns need prompt evaluation, other common explanations, and how screening and tests can guide your next steps.

References:

Marlow LAV, Waller J, & Wardle J. (2012). Barriers to cervical cancer symptom presentation among UK women… Psychooncology, 22465190.

https://pubmed.ncbi.nlm.nih.gov/22465190/

American College of Obstetricians and Gynecologists. (2011). Practice Bulletin No. 123: Screening for Cervical Cancer. Obstetrics & Gynecology, 21400049.

https://pubmed.ncbi.nlm.nih.gov/21400049/

Kamath PS, & Wiesner RH. (2001). A model to predict survival in patients with end-stage liver… Hepatology, 11157951.

https://pubmed.ncbi.nlm.nih.gov/11157951/

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Q.

Is bleeding after sex a warning sign for cervical cancer?

A.

Bleeding after sex can be a warning sign of cervical changes, but most cases are not cancer; in a large study, fewer than 1 in 500 women with this symptom were diagnosed with cervical cancer within a year, though about 5 to 7 percent had high grade precancerous changes. There are several factors to consider, and key details about other causes, red flags, and the best next steps for testing and prevention are below.

References:

Ghaem-Maghami S, & Yew MK. (2005). Postcoital bleeding as a predictor of cervical intraepithelial neoplasia… Obstet Gynecol, 15734690.

https://pubmed.ncbi.nlm.nih.gov/15734690/

Canton A, Landy R, Brocklehurst P, Singh N, Hall M, & Sasieni P. (2015). Postcoital bleeding and risk of cervical cancer: a population-based cohort study… BJOG, 25533875.

https://pubmed.ncbi.nlm.nih.gov/25533875/

Tsochatzis EA, Bosch J, & Burroughs AK. (2014). Liver cirrhosis… Lancet, 24635516.

https://pubmed.ncbi.nlm.nih.gov/24635516/

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Q.

Is the HPV vaccine effective for adults?

A.

Yes, the HPV vaccine can be effective for adults, especially if you have not been exposed to all HPV types; in women 27 to 45 who were HPV naive, it reduced persistent infection and related disease by about 88 to 96 percent. Benefits are smaller if you have prior exposure and it will not treat existing infections, but it is safe; routine vaccination is through age 26, and adults 27 to 45 may still choose it via shared decision-making based on risk of new partners, cancer prevention goals, and insurance coverage. There are several factors to consider; see below for who may benefit most, dosing, side effects, costs, and how to decide with your clinician.

References:

Walker TY, Elam-Evans LD, Yankey D, et al. (2019). Human papillomavirus vaccination for adults 27 through 45 years of age… MMWR Morb Mortal Wkly Rep, 30902220.

https://pubmed.ncbi.nlm.nih.gov/30902220/

D’Amico G, Garcia-Tsao G, Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrhosis: a systematic… J Hepatol, 12071101.

https://pubmed.ncbi.nlm.nih.gov/12071101/

European Association for the Study of the Liver. (2015). EASL clinical practice guidelines for the management of patients… Journal of Hepatology, 25607669.

https://pubmed.ncbi.nlm.nih.gov/25607669/

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Q.

What are the early signs of cervical cancer?

A.

Early signs can include abnormal vaginal bleeding (between periods, after sex, or after menopause), unusual watery or foul-smelling discharge, pelvic pain or pressure, pain during sex, and sometimes urinary changes or unexplained lower back or leg pain. Because early stages can be silent, routine Pap and HPV screening are important. There are several factors to consider that could affect your next steps, including when to see a clinician and what tests might be needed; see complete details below.

References:

Colombo N, Creutzberg C, Amant F, et al. (2019). ESMO–ESGO–ESTRO consensus conference on cervical cancer: diagnosis… Ann Oncol, 31088972.

https://pubmed.ncbi.nlm.nih.gov/31088972/

European Association for the Study of the Liver. (2018). EASL clinical practice guidelines for the management of patients… Journal of Hepatology, 30053144.

https://pubmed.ncbi.nlm.nih.gov/30053144/

D’Amico G, Garcia-Tsao G, Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrhosis… Journal of Hepatology, 16618168.

https://pubmed.ncbi.nlm.nih.gov/16618168/

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Q.

What happens during cervical cancer screening?

A.

During cervical cancer screening, a clinician performs a brief pelvic exam, gently inserts a speculum, and uses a soft brush to collect cells from the cervix for a Pap test, an HPV test, or both; it takes about 5 to 10 minutes and usually feels like pressure or mild cramping, with results in 1 to 3 weeks. There are several factors to consider that can affect next steps, including how to prepare, how often to screen by age, and what different results mean, from routine follow-up to colposcopy or treatment. See below for the complete answer to guide your next steps.

References:

Massad LS, Einstein MH, Huh WK, Katki HA, Kinney WK, Schiffman M, Wentzensen N, Lawson HW, Wilkinson EJ, & Moscicki AB. (2013). 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors… J Low Genit Tract Dis, 23697758.

https://pubmed.ncbi.nlm.nih.gov/23697758/

European Association for the Study of the Liver. (2018). EASL clinical practice guidelines for the management of patients with decompensated cirrhosis… Journal of Hepatology, 29634773.

https://pubmed.ncbi.nlm.nih.gov/29634773/

Castera L, Forns X, & Alberti A. (2008). Non-invasive evaluation of liver fibrosis using transient elastography… Journal of Hepatology, 18395322.

https://pubmed.ncbi.nlm.nih.gov/18395322/

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Q.

What symptoms occur in advanced cervical cancer?

A.

Advanced cervical cancer commonly causes abnormal vaginal bleeding, unusual discharge, pelvic or back pain and pain with sex, plus urinary or bowel changes; whole body symptoms like fatigue, weight loss and anemia can also appear. When it spreads, people may develop leg swelling, kidney or flank pain from blocked urine flow, continuous leakage of urine or stool, bone pain or fractures, cough or shortness of breath, jaundice, or neurological changes such as headaches or seizures. There are several factors to consider. See below for the complete list of symptoms, urgent red flags, how treatment side effects can mimic disease, and what next steps to take with your care team.

References:

Levit L, Moughan J, Kim A, et al. (2009). Analysis of late treatment-related toxicity in cervical carcinoma patients treated by radiotherapy with or without chemotherapy: a Gynecologic Oncology Group study… Int J Radiat Oncol Biol Phys, 19042349.

https://pubmed.ncbi.nlm.nih.gov/19042349/

D’Amico G, Garcia-Tsao G, Pagliaro L. (2006). Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies… J Hepatol, 16377968.

https://pubmed.ncbi.nlm.nih.gov/16377968/

Kamath PS, Kim WR. (2007). The model for end-stage liver disease (MELD)… Hepatology, 17488767.

https://pubmed.ncbi.nlm.nih.gov/17488767/

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References