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Redness of the skin

Rough rash in genital area

Yellow nails

Red spots on skin

Discoloration of the nails

Rough patches in my mouth

Skin is red

Not seeing your symptoms? No worries!

What is Darier Disease?

Darier disease is a genetic skin condition that typically develops in late childhood or early adulthood. Exact symptoms vary, but it involves scaly, greasy, and coarse skin lesions or blemishes. Affected sites include face (scalp margins, forehead, ears, around the nostrils and sides of nose, eyebrows, and beard area), scalp and neck, central chest and back, skin folds, such as armpits, groin, under the breasts, and between the buttocks. It can also affect nails. It is due to an abnormal gene that is involved with calcium transportation inside cells. It may be precipitated by environmental factors like heat or light, infections, or certain steroid medications.

Typical Symptoms of Darier Disease

Diagnostic Questions for Darier Disease

Your doctor may ask these questions to check for this disease:

  • Is your whole body red?
  • Do you have any rough patches in your mouth or genital area?
  • Do you have dry and flaky skin?
  • Did your nail color change?
  • Do you have itchy skin?

Treatment of Darier Disease

The disease usually lasts for life and has no cure. Medication, either taken orally or applied, can help. Moisturizers and adequate sun protection are sufficient for mild cases.

Reviewed By:

Sarita Nori, MD

Sarita Nori, MD (Dermatology)

Dr. Sarita Nori was drawn to dermatology because of the intersection of science and medicine that is at the heart of dermatology. She feels this is what really allows her to help her patients. “There is a lot of problem-solving in dermatology and I like that,” she explains. “It’s also a profession where you can help people quickly and really make a difference in their lives.” | Some of the typical skin problems that Dr. Nori treats include skin cancers, psoriasis, acne, eczema, rashes, and contact dermatitis. Dr Nori believes in using all possible avenues of treatment, such as biologics, especially in patients with chronic diseases such as eczema and psoriasis. “These medications can work superbly, and they are really life-changing for many patients.” | Dr. Nori feels it’s important for patients to have a good understanding of the disease or condition that is affecting them. “I like to educate my patients on their problem and have them really understand it so they can take the best course of action. Patients always do better when they understand their skin condition, and how to treat it.”

Yukiko Ueda, MD

Yukiko Ueda, MD (Dermatology)

Dr. Ueda graduated from the Niigata University School of Medicine and trained at the University of Tokyo Medical School. She is currently a clinical assistant professor at the Department of Dermatology, Jichi Medical University, and holds several posts in the dermatology departments at Kyoto Prefectural University of Medicine, Komagome Hospital, University of Tokyo, and the Medical Center of Japan Red Cross Society.

From our team of 50+ doctors

Content updated on Mar 31, 2024

Following the Medical Content Editorial Policy

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Link to full study:

https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1

References