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Have a fever
Fever seizures (with fever of >100.4°F / 38°C)
Twitching
My body is jerking
Brain fog
Seizure with fainting
My body is hot
Not seeing your symptoms? No worries!
Febrile seizures are seizures that occur due to high fever caused by viral infections, and less commonly, bacterial infection. They usually occur in children between the ages of 6 months and 3 years. Febrile seizures most often occur within 24 hours of the onset of a fever and can be the first sign that a child is ill. Some children inherit a family's tendency to have seizures with a fever.
Your doctor may ask these questions to check for this disease:
Medication to stop the seizures is administered through the nose (as sprays), the rectum, or injected. These medications are typically used to treat seizures that last longer than five minutes or if the child has more than one seizure within 24 hours. Medication to reduce the fever and treat infection can also beprescribed.
Reviewed By:
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Mar 31, 2024
Following the Medical Content Editorial Policy
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Gabapentin for Nerve Pain: Does It Actually Work?
A.
Gabapentin can relieve certain nerve pain, with about 30 to 50 percent of people getting meaningful but partial relief, usually after 1 to 4 weeks when doses are increased gradually, and it is generally not helpful for non-nerve pain. There are several factors to consider, including side effects, interactions with opioids or alcohol, and who should be cautious, as well as what to do if it does not work. See the complete details below to understand who benefits most, how to start and stop safely, and which alternatives might better guide your next steps with a clinician.
References:
https://pubmed.ncbi.nlm.nih.gov/28609074/
https://pubmed.ncbi.nlm.nih.gov/28609074/
https://pubmed.ncbi.nlm.nih.gov/34305417/
https://pubmed.ncbi.nlm.nih.gov/34305417/
https://pubmed.ncbi.nlm.nih.gov/28367285/
https://pubmed.ncbi.nlm.nih.gov/28367285/
https://pubmed.ncbi.nlm.nih.gov/36730302/
https://pubmed.ncbi.nlm.nih.gov/36730302/
https://pubmed.ncbi.nlm.nih.gov/31292837/
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Gabapentin Side Effects: What’s Normal vs Serious
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Common gabapentin side effects like drowsiness, dizziness or unsteadiness, blurred vision, mild stomach upset, and leg swelling are usually temporary; serious ones to act on include rash or swelling with trouble breathing, blistering skin, severe confusion or weakness, breathing problems, and new or worsening depression or suicidal thoughts. There are several factors to consider, including higher doses, interactions with opioids, benzodiazepines, or alcohol, older age or kidney disease, and the risk of seizures if you stop suddenly; see the detailed guidance below for what’s normal, when to call your doctor, and when to seek emergency care.
References:
* Sempere M, Mañas A, Sempere-García MJ, Aranda L, Sempere A. Gabapentin: a review of its use in chronic pain. *Expert Opin Pharmacother*. 2022 Aug;23(11):1227-1234. PMID: 35928812. Available from: https://pubmed.ncbi.nlm.nih.gov/35928812/
* Evoy KE, Sadarangani M, Pallerla S, Patel S, El-Gabri D, Jassal A, Taran N, Taran D, Marra K, Hooten WM, Smith ML, Sikka R, Evoy D, Evoy J. Gabapentin for Chronic Pain: A Systematic Review and Meta-analysis. *J Clin Med*. 2021 Jul 15;10(14):3139. PMID: 34292185. Available from: https://pubmed.ncbi.nlm.nih.gov/34292185/
* Wiffen PJ, Derry S, Bell RF, Rice ASC, Tölle TR, Phillips T, Smith BH, Moore RA. Gabapentin and pregabalin for acute and chronic pain in adults: a systematic review and meta-analysis of effectiveness and harms. *Cochrane Database Syst Rev*. 2019 Mar 19;3(3):CD007938. PMID: 30887629. Available from: https://pubmed.ncbi.nlm.nih.gov/30887629/
* Enabudoso A, Madorin MS, Tarrant S, Ng P, Ebidia N, Perri D, Ng K. Adverse Effects of Gabapentin in Neuropathic Pain: A Systematic Review. *Cureus*. 2018 Oct 1;10(10):e3391. PMID: 30349078. Available from: https://pubmed.ncbi.nlm.nih.gov/30349078/
* Singh V, Singh P, Kumar A, Kumar P. Gabapentin for the Treatment of Neuropathic Pain: A Review of the Current Evidence. *Cureus*. 2021 Mar 18;13(3):e13972. PMID: 33928886. Available from: https://pubmed.ncbi.nlm.nih.gov/33928886/
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Is gabapentin addictive?
A.
Gabapentin is not addictive in the traditional sense and is not federally scheduled, but it can cause physical dependence and withdrawal if stopped abruptly, and misuse can occur at high doses or in people with substance use risk. There are several factors to consider, including added risks when combined with opioids, benzodiazepines, or alcohol and the importance of a gradual taper; see below for complete details and next steps to discuss with your clinician.
References:
* Evoy KE, Copeland PM, O'Connell JR, et al. Gabapentin and Pregabalin Misuse and Abuse: A Systematic Review. *Drugs*. 2017 Jul;77(10):1059-1094. doi:10.1007/s40265-017-0744-0. PMID: 28508933; PMCID: PMC5573891.
* Peckham AM, An SB, Evoy KE, et al. Gabapentin misuse and diversion: a systematic review and meta-analysis. *Drugs*. 2019 Oct;79(15):1615-1627. doi:10.1007/s40265-019-01186-0. PMID: 31440938.
* Smith BH, Nicholson KL, Webb LS, Jaffe JA. Gabapentin and pregabalin misuse and dependence: a systematic review. *Addiction*. 2016 Feb;111(2):227-39. doi:10.1111/add.12781. Epub 2015 Oct 13. PMID: 26344214.
* Manubay JM, Manubay AT, Wuest JR, et al. Prescription Opioid and Gabapentin Misuse among Patients with Chronic Pain: Prevalence and Characteristics. *Pain Pract*. 2017 Jul;17(6):750-761. doi:10.1111/papr.12563. Epub 2017 May 17. PMID: 28370908.
* Hellwig T, Hammer B, Inderwies R. Gabapentin abuse and withdrawal: a case series. *Am J Psychiatry*. 2014 Nov;171(11):1199-200. doi:10.1176/appi.ajp.2014.14060803. PMID: 25360667.
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Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1Hashimoto R, Suto M, Tsuji M, Sasaki H, Takehara K, Ishiguro A, Kubota M. Use of antipyretics for preventing febrile seizure recurrence in children: a systematic review and meta-analysis. Eur J Pediatr. 2021 Apr;180(4):987-997. doi: 10.1007/s00431-020-03845-8. Epub 2020 Oct 30. PMID: 33125519.
https://link.springer.com/article/10.1007/s00431-020-03845-8Smith DK, Sadler KP, Benedum M. Febrile Seizures: Risks, Evaluation, and Prognosis. Am Fam Physician. 2019 Apr 1;99(7):445-450. PMID: 30932454.
https://www.aafp.org/pubs/afp/issues/2019/0401/p445.htmlSubcommittee on Febrile Seizures; American Academy of Pediatrics. Neurodiagnostic evaluation of the child with a simple febrile seizure. Pediatrics. 2011 Feb;127(2):389-94. doi: 10.1542/peds.2010-3318. PMID: 21285335.
https://publications.aap.org/pediatrics/article/127/2/389/65189/Febrile-Seizures-Guideline-for-the-NeurodiagnosticPatterson JL, Carapetian SA, Hageman JR, Kelley KR. Febrile seizures. Pediatr Ann. 2013 Dec;42(12):249-54. doi: 10.3928/00904481-20131122-09. PMID: 24295158.
https://journals.healio.com/doi/10.3928/00904481-20131122-09Febrile Seizures - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/febrile-seizure/symptoms-causes/syc-20372522