Hyperuricemia Quiz
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Joint pain
Warm or red joints
Difficult to walk
Muscle rigidity
Difficulty bending joints
Lower back pain
Blood in urine
Pain during urination
Pain in arms or legs
Swollen joints
Knee pain
Back pain worsened by exercise
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What is Hyperuricemia?
Hyperuricemia is an increased uric acid level in the blood. Causes include alcohol intake and high consumption of meat and seafood. It's also associated with health conditions such as diabetes, heart, and kidney disease. It can lead to several diseases, including gout, a painful type of arthritis.
Typical Symptoms of Hyperuricemia
- History of gout
- History of diabetes requiring medications
- Warm hands and feet
- Taking medication for high blood pressure
- Knee pain that makes kneeling difficult
- History of high uric acid in blood test
- Pain in the sole of your foot
- Previous or active smoker
Diagnostic Questions for Hyperuricemia
Your doctor may ask these questions to check for this disease:
- Have you ever been diagnosed with gout?
- Have you ever been treated for diabetes?
- Do you have warm hands and feet?
- Are you on blood pressure medication?
- Do you have knee pain that makes kneeling difficult?
Treatment of Hyperuricemia
Losing weight, exercising regularly, and limiting consumption of rich or processed foods and alcohol can help reduce uric acid levels. Doctors may prescribe medication to reduce uric acid levels in the blood.
Reviewed By:
Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.
Hidetaka Hamasaki, MD (Endocrinology)
Dr. Hamasaki graduated from the Hiroshima University School of Medicine and the Graduate School of Medicine, Jichi Medical University. He completed his residency at the Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine Hospital and the Department of Internal Medicine, Kohnodai Hospital, National Center for Global Health and Medicine. He has served in the National Center for Global Health and Medicine Hospital and Kohnodai Hospital and joined Hamasaki Clinic in April 2017. Dr. Hamasaki specializes in diabetes and treats a wide range of internal medicine and endocrine disorders.
Content updated on Feb 3, 2025
Following the Medical Content Editorial Policy
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A beginner-friendly 10-step plan can raise your VO2 max and support longevity by starting with a baseline test, building an aerobic base, adding smart intervals such as short repeats and the 4x4, following an 80/20 easy-to-hard mix, lifting weights, optimizing nutrition and body composition, prioritizing sleep and recovery, and retesting every 8 to 12 weeks. There are several factors to consider for safety and results, including when to talk with a doctor, how to spot warning symptoms, and how to adjust if you plateau; see the complete details and a sample weekly plan below.
References:
* Rosenblat MA, Perrotta AS, Kettlewell S, et al. High-Intensity Interval Training and Moderate Intensity Continuous Training for VO2max Improvement: A Systematic Review and Meta-Analysis. Int J Sports Med. 2021;42(14):1233-1246. doi:10.1055/a-1439-5028. PMID: 33946397.
* Milanović Z, Sporiš G, Weston M. Optimizing the Dose of Exercise for Maximal VO2max Improvement: A Systematic Review. Sports Med. 2016;46(12):1737-1748. doi:10.1007/s40279-016-0492-9. PMID: 27040227.
* Batacan RB Jr, Song M, Chung E, et al. Effects of high-intensity interval training on cardiorespiratory fitness in sedentary individuals: A systematic review and meta-analysis. Clin Physiol Funct Imaging. 2021;41(6):441-455. doi:10.1111/cpf.12716. PMID: 34515584.
* O'Connell J, Gaba P, Milani RV, et al. Cardiorespiratory Fitness and Mortality: A Systematic Review and Meta-Analysis. J Am Coll Cardiol. 2021;78(26):2601-2615. doi:10.1016/j.jacc.2021.10.038. PMID: 34873760.
* Joyner MJ, Lundby C. Exercise and VO2max: A narrative review of the mechanisms and determinants of training-induced increases in VO2max. Exerc Sport Sci Rev. 2019;47(4):216-222. doi:10.1249/JES.0000000000000194. PMID: 30677884.
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High C-Reactive Protein? Why Your Body Is Inflamed + Medically Approved Steps
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High C-reactive protein signals inflammation in your body, which may be from a short-term infection or from chronic issues like cardiovascular risk, autoimmune disease, obesity, smoking, or diabetes; it is a warning light, not a diagnosis. Medically approved next steps include confirming the cause with your doctor and lowering inflammation through an anti-inflammatory diet, regular exercise, healthy weight, quitting smoking, and controlling blood sugar, cholesterol, sleep, and stress. There are several factors and level thresholds that change urgency, including when values are above 3 or 10 mg/L, so see the complete guidance below.
References:
* Parray A, Sherbaz H. C-Reactive Protein as a Biomarker of Inflammation and Disease: A Narrative Review. Cureus. 2023 May 10;15(5):e38779. doi: 10.7759/cureus.38779. PMID: 37209772; PMCID: PMC10173660.
* Al-Dujaili W, Gharaibeh B, Karkin S. Lifestyle interventions and C-reactive protein: a systematic review and meta-analysis of randomized controlled trials. BMC Public Health. 2023 Nov 14;23(1):2238. doi: 10.1186/s12889-023-17242-2. PMID: 37965317; PMCID: PMC10647321.
* Al-Hakami A, Khan WA, Al-Shaikh A, Al-Dossari O, Al-Subaie F, Al-Dossari R. C-reactive protein in metabolic syndrome: A narrative review of its role and therapeutic implications. Front Endocrinol (Lausanne). 2023 Nov 29;14:1296155. doi: 10.3389/fendo.2023.1296155. PMID: 38076632; PMCID: PMC10714771.
* Esser N, Lejeune MP, Daubioul CA, Blaak EE. Chronic inflammation and C-reactive protein: The connection to COVID-19 and obesity. Clin Nutr ESPEN. 2021 Apr;42:156-163. doi: 10.1016/j.clnesp.2021.01.012. Epub 2021 Feb 23. PMID: 33671148; PMCID: PMC7900741.
* Haghighat N, Amani R, Alipour M, Afkar E, Alizadeh M. The Effect of Dietary Patterns on C-Reactive Protein Levels: A Systematic Review and Meta-Analysis. Adv Nutr. 2020 Jul 1;11(4):948-963. doi: 10.1093/advances/nmaa015. PMID: 32488344; PMCID: PMC7333116.
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
George C, Leslie SW, Minter DA. Hyperuricemia. [Updated 2023 Oct 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing
https://www.ncbi.nlm.nih.gov/books/NBK459218/Guo, K., Han, Y., Liu, S. et al. Prevalence of and trends in hyperuricemia by race and ethnicity among US adolescents, 1999–2018. Arthritis Res Ther 26, 193 (2024)
https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-024-03427-1Du, L., Zong, Y., Li, H. et al. Hyperuricemia and its related diseases: mechanisms and advances in therapy. Sig Transduct Target Ther 9, 212 (2024).
https://www.nature.com/articles/s41392-024-01916-y