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Sore throat
Fever
Whooping cough
Shortness of breath
Dry cough
Red spots on skin
Heat exhaustion
Extreme fatigue
Chronic diarrhea
Digestive issues
Frequent yeast infections
Erythema
Not seeing your symptoms? No worries!
This is a group of disorders affecting the immune system, reducing the body's ability to defend itself from infections and other diseases. A person can be born with such a condition (congenital) or acquire it (acquired). The severity and impact on the immune system can vary widely depending on the cause. Congenital conditions are usually due to inherited gene mutations, while acquired conditions can be caused by drugs, infections, long-term conditions and treatments, or other environmental factors.
Your doctor may ask these questions to check for this disease:
Treatment varies depending on the cause and involves preventing infection where possible, treating infections quickly, supplementing or strengthening the immune system, and treating the underlying cause if possible. In certain cases, a bone marrow transplant may be performed to restore the body's ability to produce healthy immune cells.
Reviewed By:
Caroline M. Doan, DO (Internal Medicine)
Dr. Doan received a Bachelor of Science degree with honors from UCLA. Prior to obtaining her medical degree, she was involved in oncology clinical research at City of Hope, a National Cancer Institute-designated comprehensive cancer center in southern California. She attended medical school at Touro University California, and completed her residency in Internal Medicine at Oregon Health & Science University. She is certified by the American Board of Internal Medicine and holds an active medical license in several states. She currently works as a physician for Signify Health providing home-based health care.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Oct 18, 2024
Following the Medical Content Editorial Policy
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With a free 3-min Immunodeficiency Syndrome quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.
This questionnaire is customized to your situation and symptoms, including the following personal information:
Biological Sex - helps us provide relevant suggestions for male vs. female conditions.
Age - adjusts our guidance based on any age-related health factors.
History - considers past illnesses, surgeries, family history, and lifestyle choices.
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Q.
Quercetin Over 65: Longevity and Immune Support
A.
Quercetin may help adults over 65 by supporting immune balance, moderating inflammation, and contributing to healthy aging, with food sources favored and supplements used carefully. There are several factors to consider; see below for realistic benefits, dosing, and how it fits with exercise, sleep, and vaccinations. Because safety and interactions matter in this age group, especially with blood thinners, certain antibiotics or heart medicines, kidney disease, and cancer or immune therapies, talk with your clinician and start low if appropriate. See the complete guidance below for who should avoid it, side effects to watch, when to seek care, and why it is a supportive tool rather than a cure.
References:
* Liu Z, Liu H, Han G, Ma S, Li Y, Wang Z. Quercetin and its derivatives as promising candidates for the prevention and treatment of aging-related disorders: an updated review. Pharmacol Res. 2023 Sep;195:106886. doi: 10.1016/j.phrs.2023.106886. Epub 2023 Jun 24. PMID: 37376092.
* Amanullah A, Al-Otaibi SM, Alotaibi SS, Alotaibi A, Al-Malki FM. Quercetin Supplementation for the Elderly: A Narrative Review of Its Effects on Age-Related Diseases and Immune Function. J Multidiscip Healthc. 2022 Aug 4;15:1739-1750. doi: 10.2147/JMDH.S375253. PMID: 35955615; PMCID: PMC9364998.
* Palmer S, Chen S, Sacks D, Khosla S. Senolytics and Senomorphics as Potential Therapies for Immune Aging. Int J Mol Sci. 2022 Dec 15;23(24):15918. doi: 10.3390/ijms232415918. PMID: 36556133; PMCID: PMC9779383.
* Wang R, Tang H, Shi W, Chen P, Yang Z, Yu Y, Huang J, Xu Y. Senolytics and Senomorphics: The Promising Role of Quercetin in Age-Related Diseases. Oxid Med Cell Longev. 2021 Aug 6;2021:6677945. doi: 10.1155/2021/6677945. PMID: 34368417; PMCID: PMC8364749.
* Fraga CG, Oteiza PI, Galleano M. Dietary polyphenols in the management of immunosenescence. J Nutr Biochem. 2019 Sep;71:1-12. doi: 10.1016/j.jnutbio.2019.05.006. Epub 2019 May 31. PMID: 31284566.
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1Chen LF, Yang CD, Cheng XB. Anti-Interferon Autoantibodies in Adult-Onset Immunodeficiency Syndrome and Severe COVID-19 Infection. Front Immunol. 2021 Dec 22;12:788368. doi: 10.3389/fimmu.2021.788368. PMID: 35003106; PMCID: PMC8727472.
https://www.frontiersin.org/articles/10.3389/fimmu.2021.788368/fullZhang Q, Jing H, Su HC. Recent Advances in DOCK8 Immunodeficiency Syndrome. J Clin Immunol. 2016 Jul;36(5):441-9. doi: 10.1007/s10875-016-0296-z. Epub 2016 May 20. PMID: 27207373; PMCID: PMC4914394.
https://link.springer.com/article/10.1007/s10875-016-0296-z