Immunodeficiency Syndrome Quiz
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Sore throat
Fever
Whooping cough
Shortness of breath
Dry cough
Red spots on skin
Heat exhaustion
Extreme fatigue
Chronic diarrhea
Digestive issues
Frequent yeast infections
Erythema
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What is Immunodeficiency Syndrome?
This is a group of disorders affecting the immune system, reducing the body's ability to defend itself from infections and other diseases. A person can be born with such a condition (congenital) or acquire it (acquired). The severity and impact on the immune system can vary widely depending on the cause. Congenital conditions are usually due to inherited gene mutations, while acquired conditions can be caused by drugs, infections, long-term conditions and treatments, or other environmental factors.
Typical Symptoms of Immunodeficiency Syndrome
- Fever above 100.4°F / 38°C lasting 7 days or longer
- Whole body pain
- Fever
- Recurrent fever episodes
- Headache
- Skin lumps
- Swollen lymph nodes or lumps in the neck, armpits, groin, or behind the ears
- Muscle pain
Diagnostic Questions for Immunodeficiency Syndrome
Your doctor may ask these questions to check for this disease:
- Have you had a fever above 100.4°F / 38°C for 7 days or longer?
- Do you have pain all over your body?
- Do you have a fever?
- Do you have recurrent fever episodes?
- Do you have a headache?
Treatment of Immunodeficiency Syndrome
Treatment varies depending on the cause and involves preventing infection where possible, treating infections quickly, supplementing or strengthening the immune system, and treating the underlying cause if possible. In certain cases, a bone marrow transplant may be performed to restore the body's ability to produce healthy immune cells.
Reviewed By:
Caroline M. Doan, DO (Internal Medicine)
Dr. Doan received a Bachelor of Science degree with honors from UCLA. Prior to obtaining her medical degree, she was involved in oncology clinical research at City of Hope, a National Cancer Institute-designated comprehensive cancer center in southern California. She attended medical school at Touro University California, and completed her residency in Internal Medicine at Oregon Health & Science University. She is certified by the American Board of Internal Medicine and holds an active medical license in several states. She currently works as a physician for Signify Health providing home-based health care.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Oct 18, 2024
Following the Medical Content Editorial Policy
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With a free 3-min Immunodeficiency Syndrome quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- My whole body aches and I feel weak
- Have a fever
- Body aches and chills
- Have a headache
- My body is hot
- Joint pain and stiffness all over body
- Whole body aches no fever
- Recurrent fevers
- Pulsating headache
- My whole body hurts
- Periodic fever (>100.4°F / 38°C)
- Whole body pain
- Headache on the side of my head
- Fever then no fever then fever again
- Remittent fever of 102.2°F / 39°C
See full list
Symptoms Related to Immunodeficiency Syndrome
Diseases Related to Immunodeficiency Syndrome
FAQs
Q.
Low WBC Count? Why Your Immune System Is Failing & Medically Approved Next Steps
A.
Low WBC counts (leukopenia) can be temporary and treatable or signal deeper problems; common causes include recent viral illness, medications including chemotherapy, autoimmune disease, vitamin B12 or folate deficiency, bone marrow disorders, and spleen trapping, and it is most urgent if neutrophils are very low or you develop a fever. Medically approved next steps are to repeat a CBC with differential, identify and treat the cause through targeted tests and therapy, use infection precautions, and consider growth factors for severe neutropenia; there are several factors to consider, so see below for complete details that can shape your next steps with your clinician.
References:
* Smith, A. G., & Smith, M. P. (2023). Leukopenia. In *StatPearls*. StatPearls Publishing.
* Newburger, P. E., & Dale, D. C. (2018). Neutropenia: a clinical approach to diagnosis and treatment. *The American Journal of Medicine*, *131*(12), 1421-1428.
* Modell, V., Kolisko, N., Modell, F., & Orange, J. S. (2019). Primary Immunodeficiency Diseases: An Update. *Clinical Reviews in Allergy & Immunology*, *57*(3), 299-311.
* Coustan-Smith, E., & Leung, W. (2017). Chronic neutropenia: etiologies and clinical management. *Blood*, *130*(15), 1719-1725.
* Jäkel, A., & Litzman, J. (2020). Lymphopenia: a common, important, but often unrecognized problem. *Journal of Allergy and Clinical Immunology: In Practice*, *8*(1), 107-115.
Q.
Always getting sick? Why your white cells are failing and the vital medical steps for Neutropenia
A.
Frequent or severe infections can signal neutropenia, a low neutrophil count that weakens first-line defense and makes any fever urgent; a simple CBC checks your ANC. There are several factors to consider, from causes like chemo, bone marrow or vitamin issues and autoimmune disease to key steps like repeat tests, targeted treatment including antibiotics or G-CSF, and day-to-day precautions; see the complete guidance below for details that could change your next steps.
References:
* Newburger PE, Dale DC. Neutropenia: a clinical and laboratory approach. Blood Rev. 2017 Nov;31(6):387-392. doi: 10.1016/j.blre.2017.04.002. Epub 2017 Apr 26. PMID: 28867375.
* Carlsson G, Fasth A. Diagnosis and management of chronic neutropenia: consensus and controversies. J Blood Med. 2017 Nov 22;8:137-148. doi: 10.2147/JBM.S124702. PMID: 29203928; PMCID: PMC5704988.
* Alexander S, et al. Management of febrile neutropenia in adults: 2023 update by the Infectious Diseases Society of America Clinical Practice Guidelines. Clin Infect Dis. 2023 Oct 4;ciad560. doi: 10.1093/cid/ciad560. Epub ahead of print. PMID: 37780072.
* Zent CS. Diagnosis and treatment of autoimmune neutropenia. Curr Opin Hematol. 2020 Jul;27(4):279-286. doi: 10.1097/MOH.0000000000000599. PMID: 32205562.
* Plocharski B, et al. Primary Immune Neutropenias. Front Immunol. 2021 Jul 20;12:697207. doi: 10.3389/fimmu.2021.697207. PMID: 34367098; PMCID: PMC8333502.
Q.
Quercetin Over 65: Longevity and Immune Support
A.
Quercetin may help adults over 65 by supporting immune balance, moderating inflammation, and contributing to healthy aging, with food sources favored and supplements used carefully. There are several factors to consider; see below for realistic benefits, dosing, and how it fits with exercise, sleep, and vaccinations. Because safety and interactions matter in this age group, especially with blood thinners, certain antibiotics or heart medicines, kidney disease, and cancer or immune therapies, talk with your clinician and start low if appropriate. See the complete guidance below for who should avoid it, side effects to watch, when to seek care, and why it is a supportive tool rather than a cure.
References:
* Liu Z, Liu H, Han G, Ma S, Li Y, Wang Z. Quercetin and its derivatives as promising candidates for the prevention and treatment of aging-related disorders: an updated review. Pharmacol Res. 2023 Sep;195:106886. doi: 10.1016/j.phrs.2023.106886. Epub 2023 Jun 24. PMID: 37376092.
* Amanullah A, Al-Otaibi SM, Alotaibi SS, Alotaibi A, Al-Malki FM. Quercetin Supplementation for the Elderly: A Narrative Review of Its Effects on Age-Related Diseases and Immune Function. J Multidiscip Healthc. 2022 Aug 4;15:1739-1750. doi: 10.2147/JMDH.S375253. PMID: 35955615; PMCID: PMC9364998.
* Palmer S, Chen S, Sacks D, Khosla S. Senolytics and Senomorphics as Potential Therapies for Immune Aging. Int J Mol Sci. 2022 Dec 15;23(24):15918. doi: 10.3390/ijms232415918. PMID: 36556133; PMCID: PMC9779383.
* Wang R, Tang H, Shi W, Chen P, Yang Z, Yu Y, Huang J, Xu Y. Senolytics and Senomorphics: The Promising Role of Quercetin in Age-Related Diseases. Oxid Med Cell Longev. 2021 Aug 6;2021:6677945. doi: 10.1155/2021/6677945. PMID: 34368417; PMCID: PMC8364749.
* Fraga CG, Oteiza PI, Galleano M. Dietary polyphenols in the management of immunosenescence. J Nutr Biochem. 2019 Sep;71:1-12. doi: 10.1016/j.jnutbio.2019.05.006. Epub 2019 May 31. PMID: 31284566.
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Which is the best Symptom Checker?
Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Chen LF, Yang CD, Cheng XB. Anti-Interferon Autoantibodies in Adult-Onset Immunodeficiency Syndrome and Severe COVID-19 Infection. Front Immunol. 2021 Dec 22;12:788368. doi: 10.3389/fimmu.2021.788368. PMID: 35003106; PMCID: PMC8727472.
https://www.frontiersin.org/articles/10.3389/fimmu.2021.788368/fullZhang Q, Jing H, Su HC. Recent Advances in DOCK8 Immunodeficiency Syndrome. J Clin Immunol. 2016 Jul;36(5):441-9. doi: 10.1007/s10875-016-0296-z. Epub 2016 May 20. PMID: 27207373; PMCID: PMC4914394.
https://link.springer.com/article/10.1007/s10875-016-0296-z