Paroxysmal Nocturnal Hemoglobinuria Quiz
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Reviewed By:
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Mar 31, 2024
Following the Medical Content Editorial Policy
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Easily tired
Blood in urine
Easily fatigued
Blood in pee
Easy to get tired
Hematuria
Susceptibility to fatigue
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Try Free Symptom QuizWhat is Paroxysmal Nocturnal Hemoglobinuria?
Paroxysmal nocturnal hemoglobinuria is a rare, life-threatening blood disease. It is characterized by red blood cell destruction, blood clots, and impaired bone marrow function.
Typical Symptoms of Paroxysmal Nocturnal Hemoglobinuria
- Urine appears red or bloody mostly in the mornings
- Bloody or red urine
- Abdominal pain
- Difficulty achieving or maintaining an erection
- Fatigue
- Low red blood cell count on blood test
- History of deep vein thrombosis / blood clot in my leg veins
- Fatigue that is worst in the morning
Diagnostic Questions for Paroxysmal Nocturnal Hemoglobinuria
Your doctor may ask these questions to check for this disease:
- Does your urine appear red or bloody in the morning?
- Have you ever had red or brown urine?
- Do you have a stomach ache?
- Are you worried about your sexual performance because you can't get or keep an erection for sex?
- Do you feel you fatigued?
Treatment of Paroxysmal Nocturnal Hemoglobinuria
Treatment depends on symptom severity. Options include medication therapy and bone marrow transplant.
Think you might have
Paroxysmal Nocturnal Hemoglobinuria?
Try a symptom check testSymptoms Related to Paroxysmal Nocturnal Hemoglobinuria
Diseases Related to Paroxysmal Nocturnal Hemoglobinuria
References
Brodsky RA. Paroxysmal nocturnal hemoglobinuria. Blood. 2014 Oct 30;124(18):2804-11. doi: 10.1182/blood-2014-02-522128. Epub 2014 Sep 18. PMID: 25237200; PMCID: PMC4215311.
https://ashpublications.org/blood/article/124/18/2804/33385/Paroxysmal-nocturnal-hemoglobinuriaDevalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review. Eur J Haematol. 2015 Sep;95(3):190-8. doi: 10.1111/ejh.12543. Epub 2015 Mar 26. PMID: 25753400.
https://onlinelibrary.wiley.com/doi/10.1111/ejh.12543Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R, Hillmen P, Luzzatto L, Young N, Kinoshita T, Rosse W, Socié G; International PNH Interest Group. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005 Dec 1;106(12):3699-709. doi: 10.1182/blood-2005-04-1717. Epub 2005 Jul 28. PMID: 16051736; PMCID: PMC1895106.
https://ashpublications.org/blood/article/106/12/3699/109767/Diagnosis-and-management-of-paroxysmal-nocturnalBektas M, Copley-Merriman C, Khan S, Sarda SP, Shammo JM. Paroxysmal nocturnal hemoglobinuria: current treatments and unmet needs. J Manag Care Spec Pharm. 2020 Dec;26(12-b Suppl):S14-S20. doi: 10.18553/jmcp.2020.26.12-b.s14. PMID: 33356783.
https://www.jmcp.org/doi/10.18553/jmcp.2020.26.12-b.s14
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Reviewed By:
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
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