Paroxysmal Nocturnal Hemoglobinuria Quiz
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Learn more about Paroxysmal nocturnal hemoglobinuria
Content updated on Nov 2, 2022
What is paroxysmal nocturnal hemoglobinuria?
Paroxysmal nocturnal hemoglobinuria is a rare and life-threatening disease of the blood. The disease is characterized by destruction of red blood cells, blood clots, and impaired bone marrow function.
Symptoms of paroxysmal nocturnal hemoglobinuria
Bloody or red urine
Easily fatigued
Questions your doctor may ask to check for paroxysmal nocturnal hemoglobinuria
Your doctor may ask these questions to diagnose paroxysmal nocturnal hemoglobinuria
Have you ever had red or brown urine (hematuria)?
Do you get tired easily?
Treatment for paroxysmal nocturnal hemoglobinuria
Treatment depends on the severity of the symptoms. Options include medication therapy and bone marrow transplant.
View the symptoms of Paroxysmal nocturnal hemoglobinuria
Diseases related to Paroxysmal nocturnal hemoglobinuria
References
Brodsky RA. Paroxysmal nocturnal hemoglobinuria. Blood. 2014 Oct 30;124(18):2804-11. doi: 10.1182/blood-2014-02-522128. Epub 2014 Sep 18. PMID: 25237200; PMCID: PMC4215311.
https://ashpublications.org/blood/article/124/18/2804/33385/Paroxysmal-nocturnal-hemoglobinuria
Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review. Eur J Haematol. 2015 Sep;95(3):190-8. doi: 10.1111/ejh.12543. Epub 2015 Mar 26. PMID: 25753400.
https://onlinelibrary.wiley.com/doi/10.1111/ejh.12543
Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R, Hillmen P, Luzzatto L, Young N, Kinoshita T, Rosse W, Socié G; International PNH Interest Group. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005 Dec 1;106(12):3699-709. doi: 10.1182/blood-2005-04-1717. Epub 2005 Jul 28. PMID: 16051736; PMCID: PMC1895106.
https://ashpublications.org/blood/article/106/12/3699/109767/Diagnosis-and-management-of-paroxysmal-nocturnal
Bektas M, Copley-Merriman C, Khan S, Sarda SP, Shammo JM. Paroxysmal nocturnal hemoglobinuria: current treatments and unmet needs. J Manag Care Spec Pharm. 2020 Dec;26(12-b Suppl):S14-S20. doi: 10.18553/jmcp.2020.26.12-b.s14. PMID: 33356783.
https://www.jmcp.org/doi/10.18553/jmcp.2020.26.12-b.s14
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Seiji Kanazawa, MD, PHD
Obstetrics and gynecology (OBGYN)
National Center for Child Health and Development, Japan