Paroxysmal Nocturnal Hemoglobinuria Quiz

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Yoshinori Abe, MD (Internal medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

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Learn more about Paroxysmal nocturnal hemoglobinuria

Content updated on Nov 2, 2022

What is paroxysmal nocturnal hemoglobinuria?

Paroxysmal nocturnal hemoglobinuria is a rare, life-threatening blood disease. It is characterized by red blood cell destruction, blood clots, and impaired bone marrow function.

Symptoms of paroxysmal nocturnal hemoglobinuria

  • Bloody or red urine

  • Abdominal pain

  • Urine appears red or bloody mostly in the mornings

  • Easily fatigued

  • Feeling breathless

Questions your doctor may ask to check for paroxysmal nocturnal hemoglobinuria

Your doctor may ask these questions to diagnose paroxysmal nocturnal hemoglobinuria

  • Have you ever had red or brown urine (hematuria)?

  • Do you have abdominal pain (stomach ache)?

  • Do you notice your urine appearing red or bloody predominantly in the morning?

  • Do you get tired easily?

  • Are you breathless or having hard time breathing?

Treatment for paroxysmal nocturnal hemoglobinuria

Treatment depends on symptom severity. Options include medication therapy and bone marrow transplant.

View the symptoms of Paroxysmal nocturnal hemoglobinuria

References

  • Brodsky RA. Paroxysmal nocturnal hemoglobinuria. Blood. 2014 Oct 30;124(18):2804-11. doi: 10.1182/blood-2014-02-522128. Epub 2014 Sep 18. PMID: 25237200; PMCID: PMC4215311.

    https://ashpublications.org/blood/article/124/18/2804/33385/Paroxysmal-nocturnal-hemoglobinuria

  • Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review. Eur J Haematol. 2015 Sep;95(3):190-8. doi: 10.1111/ejh.12543. Epub 2015 Mar 26. PMID: 25753400.

    https://onlinelibrary.wiley.com/doi/10.1111/ejh.12543

  • Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R, Hillmen P, Luzzatto L, Young N, Kinoshita T, Rosse W, Socié G; International PNH Interest Group. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005 Dec 1;106(12):3699-709. doi: 10.1182/blood-2005-04-1717. Epub 2005 Jul 28. PMID: 16051736; PMCID: PMC1895106.

    https://ashpublications.org/blood/article/106/12/3699/109767/Diagnosis-and-management-of-paroxysmal-nocturnal

  • Bektas M, Copley-Merriman C, Khan S, Sarda SP, Shammo JM. Paroxysmal nocturnal hemoglobinuria: current treatments and unmet needs. J Manag Care Spec Pharm. 2020 Dec;26(12-b Suppl):S14-S20. doi: 10.18553/jmcp.2020.26.12-b.s14. PMID: 33356783.

    https://www.jmcp.org/doi/10.18553/jmcp.2020.26.12-b.s14

User testimonials

Reviewed By:

Yoshinori Abe, MD

Yoshinori Abe, MD (Internal medicine)

Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.

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