Paroxysmal Nocturnal Hemoglobinuria Quiz
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Yoshinori Abe, MD (Internal medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
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Learn more about Paroxysmal nocturnal hemoglobinuria
Content updated on Nov 2, 2022
What is paroxysmal nocturnal hemoglobinuria?
Paroxysmal nocturnal hemoglobinuria is a rare, life-threatening blood disease. It is characterized by red blood cell destruction, blood clots, and impaired bone marrow function.
Symptoms of paroxysmal nocturnal hemoglobinuria
Bloody or red urine
Abdominal pain
Urine appears red or bloody mostly in the mornings
Easily fatigued
Feeling breathless
Questions your doctor may ask to check for paroxysmal nocturnal hemoglobinuria
Your doctor may ask these questions to diagnose paroxysmal nocturnal hemoglobinuria
Have you ever had red or brown urine (hematuria)?
Do you have abdominal pain (stomach ache)?
Do you notice your urine appearing red or bloody predominantly in the morning?
Do you get tired easily?
Are you breathless or having hard time breathing?
Treatment for paroxysmal nocturnal hemoglobinuria
Treatment depends on symptom severity. Options include medication therapy and bone marrow transplant.
View the symptoms of Paroxysmal nocturnal hemoglobinuria
Diseases related to Paroxysmal nocturnal hemoglobinuria
References
Brodsky RA. Paroxysmal nocturnal hemoglobinuria. Blood. 2014 Oct 30;124(18):2804-11. doi: 10.1182/blood-2014-02-522128. Epub 2014 Sep 18. PMID: 25237200; PMCID: PMC4215311.
https://ashpublications.org/blood/article/124/18/2804/33385/Paroxysmal-nocturnal-hemoglobinuria
Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review. Eur J Haematol. 2015 Sep;95(3):190-8. doi: 10.1111/ejh.12543. Epub 2015 Mar 26. PMID: 25753400.
https://onlinelibrary.wiley.com/doi/10.1111/ejh.12543
Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R, Hillmen P, Luzzatto L, Young N, Kinoshita T, Rosse W, Socié G; International PNH Interest Group. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005 Dec 1;106(12):3699-709. doi: 10.1182/blood-2005-04-1717. Epub 2005 Jul 28. PMID: 16051736; PMCID: PMC1895106.
https://ashpublications.org/blood/article/106/12/3699/109767/Diagnosis-and-management-of-paroxysmal-nocturnal
Bektas M, Copley-Merriman C, Khan S, Sarda SP, Shammo JM. Paroxysmal nocturnal hemoglobinuria: current treatments and unmet needs. J Manag Care Spec Pharm. 2020 Dec;26(12-b Suppl):S14-S20. doi: 10.18553/jmcp.2020.26.12-b.s14. PMID: 33356783.
https://www.jmcp.org/doi/10.18553/jmcp.2020.26.12-b.s14
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Reviewed By:
Yoshinori Abe, MD (Internal medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
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