Premature Ovarian Failure Quiz

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Seiji Kanazawa, MD, PHD (Obstetrics and gynecology (OBGYN))

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Learn more about Premature ovarian failure

Content updated on Sep 20, 2022

What is premature ovarian failure?

Normal menopause begins between the age of 45 and 55. When it happens too early (less than 40 years old), it is known as premature ovarian failure. Causes include chemotherapy, however, in 90% of cases no clear cause is found.

Symptoms of premature ovarian failure

  • Abnormal period length or flow

  • Difficulty getting pregnant

  • Abnormal menstrual cycles e.g. too early or too late

Questions your doctor may ask to check for premature ovarian failure

Your doctor may ask these questions to diagnose premature ovarian failure

  • Are your periods abnormal e.g. in duration or amount of bleeding?

  • Are you having trouble getting pregnant despite trying for some time?

  • Do you have abnormal menstrual cycles e.g. too early or too late

Treatment for premature ovarian failure

Treatment for this aims to correct hormone imbalances and prolong periods until the age of normal menopause. This is done through hormone replacement therapy. The doctor may also prescribe Vitamin D and calcium supplements to prevent bone weakening.

View the symptoms of Premature ovarian failure

Diseases related to Premature ovarian failure


  • Kawamura K, Kawamura N, Hsueh AJ. Activation of dormant follicles: a new treatment for premature ovarian failure? Curr Opin Obstet Gynecol. 2016 Jun;28(3):217-22. doi: 10.1097/GCO.0000000000000268. PMID: 27022685; PMCID: PMC5536116.

  • Barlow DH. Premature ovarian failure. Baillieres Clin Obstet Gynaecol. 1996 Sep;10(3):361-84. doi: 10.1016/s0950-3552(96)80020-4. PMID: 8931900.

Reviewed By:

Seiji Kanazawa

Seiji Kanazawa, MD, PHD (Obstetrics and gynecology (OBGYN))

From our team of 50+ doctors

Just 3 minutes.
Developed by doctors.

Ubie is supervised by 50+ medical experts worldwide

Shohei Harase

Shohei Harase, MD


Kameda Medical Center, Japan

Yu Shirai

Yu Shirai, MD


Yotsuya Yui Clinic, Japan

Yoshinori Abe

Yoshinori Abe, MD

Internal medicine

Co-founder of Ubie, Inc.

Rohini R

Rohini R, MD

Ear, nose, throat (ENT)

Bayshore Health Centre, India

Seiji Kanazawa

Seiji Kanazawa, MD, PHD

Obstetrics and gynecology (OBGYN)

National Center for Child Health and Development, Japan

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