Primary Immunodeficiency Syndrome Quiz
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Lumps under armpits
Swollen lymph nodes
Weight loss
Loss of appetite
Swelling under ribs
Body pain
Joint pain
Digestive issues including diarrhea
Difficulty swallowing food or water
Swollen areas in the neck
Frequent infections
Falling sick often
Not seeing your symptoms? No worries!
What is Primary Immunodeficiency Syndrome?
PIDDs (primary immune deficiency diseases) are rare inherited disorders that affect the immune system. People with PIDDs may be vulnerable to chronic, severe infections because their immune systems aren't functioning properly.
Typical Symptoms of Primary Immunodeficiency Syndrome
- Fever of at least 100.4°F / 38°C that continues for 7 or more days
- Fever
- Repeated episodes of fever above 100.4°F / 38°C
- Skin lumps
- Allergic symptoms are present all year round
- Whole body pain
- Swollen lymph nodes or lumps in the neck, armpits, groin, or behind the ears
- Difficulty speaking, performing tasks, or recognizing things
Diagnostic Questions for Primary Immunodeficiency Syndrome
Your doctor may ask these questions to check for this disease:
- Do you have a fever of 100.4°F / 38°C or higher for more than 7 days?
- Do you have a fever?
- Have you had recurring fevers of 100.4°F / 38°C or higher?
- Have you noticed any lumps on your skin?
- Do you have eczema all throughout the year?
Treatment of Primary Immunodeficiency Syndrome
While there is no cure for PIDDs, various treatments can help individuals maintain good health and lead active lives. The only potential curative options are hematopoietic stem cell transplantation or gene therapy. Supportive treatments, including antibiotics and antivirals, are used to manage and prevent infections.
Reviewed By:
Caroline M. Doan, DO (Internal Medicine)
Dr. Doan received a Bachelor of Science degree with honors from UCLA. Prior to obtaining her medical degree, she was involved in oncology clinical research at City of Hope, a National Cancer Institute-designated comprehensive cancer center in southern California. She attended medical school at Touro University California, and completed her residency in Internal Medicine at Oregon Health & Science University. She is certified by the American Board of Internal Medicine and holds an active medical license in several states. She currently works as a physician for Signify Health providing home-based health care.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Jan 23, 2025
Following the Medical Content Editorial Policy
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- Have a fever
- Lumps under skin
- My body is hot
- Recurrent fevers
- Reddish skin lumps
- Periodic fever (>100.4°F / 38°C)
- Fever then no fever then fever again
- Bumps on my arm
- Remittent fever of 102.2°F / 39°C
- Extremely high fever of 106.7°F / 41.5°C or higher
- Lumps on my wrist
- Fever of 100.4°F / 38°C or more for weeks
- Stomach was uncomfortable, then had a fever
- Pink, bumpy skin
- Stomachache and diarrhea before a fever
See full list
Symptoms Related to Primary Immunodeficiency Syndrome
Diseases Related to Primary Immunodeficiency Syndrome
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Which is the best Symptom Checker?
Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Meyts I, Bousfiha A, Duff C, Singh S, Lau YL, Condino-Neto A, Bezrodnik L, Ali A, Adeli M, Drabwell J. Primary Immunodeficiencies: A Decade of Progress and a Promising Future. Front Immunol. 2021 Feb 18;11:625753. doi: 10.3389/fimmu.2020.625753. PMID: 33679719; PMCID: PMC7935502.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7935502/McCusker C, Upton J, Warrington R. Primary immunodeficiency. Allergy Asthma Clin Immunol. 2018 Sep 12;14(Suppl 2):61. doi: 10.1186/s13223-018-0290-5. PMID: 30275850; PMCID: PMC6157160.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6157160/Bonilla FA. Diagnosis and Management of Primary Immune Deficiency. Clin Rev Allergy Immunol. 2022;62(3):251-269. doi:10.1016/j.jaci.2022.04.016
https://www.sciencedirect.com/science/article/pii/S1098360021019845Chinn, Ivan K. et al., Diagnostic interpretation of genetic studies in patients with primary immunodeficiency diseases: A working group report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma & Immunology, Journal of Allergy and Clinical Immunology, Volume 145, Issue 1, 46 - 69
https://www.jacionline.org/article/S0091-6749(19)31245-X/fulltext