Secondary Immunodeficiency Syndrome Quiz
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Frequent infections
Falling sick often
Weight loss
Loss of appetite
Ear infections
Joint pain
Digestive issues including diarrhea
Lumps under armpits
Swollen lymph nodes
Swelling under ribs
Difficulty swallowing food or water
Swollen areas in the neck
Not seeing your symptoms? No worries!
What is Secondary Immunodeficiency Syndrome?
Secondary immunodeficiency syndrome results in a weakened immune system due to an underlying condition or external factors.
Typical Symptoms of Secondary Immunodeficiency Syndrome
- Fever of at least 100.4°F / 38°C that continues for 7 or more days
- Whole body pain
- Fever
- Repeated episodes of fever above 100.4°F / 38°C
- Currently undergoing chemotherapy
- Skin lumps
- Taking steroids
- Diagnosed with Leukemia in the past
Diagnostic Questions for Secondary Immunodeficiency Syndrome
Your doctor may ask these questions to check for this disease:
- Do you have a fever of 100.4°F / 38°C or higher for more than 7 days?
- Do you have pain all over your body?
- Do you have a fever?
- Have you had recurring fevers of 100.4°F / 38°C or higher?
- Are you currently on chemotherapy?
Treatment of Secondary Immunodeficiency Syndrome
Treatment for secondary immunodeficiency syndrome focuses on managing the underlying condition causing the immunodeficiency. This may include antibiotics for infections, immunoglobulin replacement therapy, and treatment for any associated illnesses or malignancies.
Reviewed By:
Caroline M. Doan, DO (Internal Medicine)
Dr. Doan received a Bachelor of Science degree with honors from UCLA. Prior to obtaining her medical degree, she was involved in oncology clinical research at City of Hope, a National Cancer Institute-designated comprehensive cancer center in southern California. She attended medical school at Touro University California, and completed her residency in Internal Medicine at Oregon Health & Science University. She is certified by the American Board of Internal Medicine and holds an active medical license in several states. She currently works as a physician for Signify Health providing home-based health care.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Jan 23, 2025
Following the Medical Content Editorial Policy
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History - considers past illnesses, surgeries, family history, and lifestyle choices.
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- My whole body aches and I feel weak
- Have a fever
- Body aches and chills
- My body is hot
- Joint pain and stiffness all over body
- Whole body aches no fever
- Recurrent fevers
- My whole body hurts
- Periodic fever (>100.4°F / 38°C)
- Whole body pain
- Fever then no fever then fever again
- Remittent fever of 102.2°F / 39°C
- Extremely high fever of 106.7°F / 41.5°C or higher
- Fever of 100.4°F / 38°C or more for weeks
- Stomach was uncomfortable, then had a fever
See full list
Symptoms Related to Secondary Immunodeficiency Syndrome
Diseases Related to Secondary Immunodeficiency Syndrome
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Tuano KS, Seth N, Chinen J. Secondary immunodeficiencies: An overview. Ann Allergy Asthma Immunol. 2021 Dec;127(6):617-626. doi: 10.1016/j.anai.2021.08.413. Epub 2021 Sep 3. PMID: 34481993.
https://pubmed.ncbi.nlm.nih.gov/34481993/Szepanowski F, Warnke C, Meyer Zu Hörste G, Mausberg AK, Hartung HP, Kleinschnitz C, Stettner M. Secondary Immunodeficiency and Risk of Infection Following Immune Therapies in Neurology. CNS Drugs. 2021 Nov;35(11):1173-1188. doi: 10.1007/s40263-021-00863-4. Epub 2021 Oct 16. PMID: 34657228; PMCID: PMC8520462.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8520462/Chinen J, Shearer WT. Secondary immunodeficiencies, including HIV infection. J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S195-203. doi: 10.1016/j.jaci.2009.08.040. Epub 2009 Dec 29. PMID: 20042227; PMCID: PMC6151868.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6151868/#:~:text=Secondary%20immunodeficiencies%20result%20from%20a,metabolic%20diseases%2C%20and%20environmental%20conditions.