Reviewed By:
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Hidetaka Hamasaki, MD (Endocrinology)
Dr. Hamasaki graduated from the Hiroshima University School of Medicine and the Graduate School of Medicine, Jichi Medical University. He completed his residency at the Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine Hospital and the Department of Internal Medicine, Kohnodai Hospital, National Center for Global Health and Medicine. He has served in the National Center for Global Health and Medicine Hospital and Kohnodai Hospital and joined Hamasaki Clinic in April 2017. Dr. Hamasaki specializes in diabetes and treats a wide range of internal medicine and endocrine disorders.
Content updated on Jan 15, 2024
Following the Medical Content Editorial Policy
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Try one of these related symptoms.
Delayed puberty
Lack of secondary sexual characteristics
No testicular enlargement
No pubic hair
Menstruation did not occur
Never had voice change
With an easy 3-min questionnaire , Ubie's AI-powered system will generate a free report on possible causes.
Questions are customized to your situation and symptoms, including the following personal information:
Biological Sex - helps us provide relevant suggestions for male vs. female conditions.
Age - adjusts our guidance based on any age-related health factors.
History - considers past illnesses, surgeries, family history, and lifestyle choices.
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It describes the absence of secondary-sexual characteristics which are the result of hormonal changes in the body during puberty. Growth of pubic hair, facial hair, or an increase in height are some of the secondary sexual characteristics. Most times there is no known cause however sometimes it can be due to chromosomal problems, genetic disorders, chronic illness, tumors of the pituitary gland or hypothalamus, underactive pituitary gland (hypopituitarism), underactive thyroid (hypothyroidism), abnormal development of the reproductive system, inability of the body to use androgen hormones (complete androgen insensitivity syndrome)or too much exercise.
Seek professional care if you experience any of the following symptoms
Generally, Late or incomplete puberty can be related to:
A condition where menarche (first period for a girl) does not occur on time. Typically absence of first period by age 15 is considered abnormal, but this does vary by ethnicity and location. Causes include problems with malnutrition, genetic disorders, formation of the reproductive system and hormonal imbalances. Primary amenorrhea typically needs evaluation with a specialist to find the correct diagnosis and treatment.
Uterine hypoplasia, also known as a hypoplastic uterus, occurs when a girl is born with an abnormally small uterus. Symptoms may include failure to start having periods at puberty (primary amenorrhea), abdominal pain, a small or no vaginal opening, or infertility.
Instead of having 2 X chromosomes (XX), one X chromosome is partially or completely missing (XO). This occurs randomly and only in women. Some developmental abnormalities include short stature, ovarian failure and heart defects.
Sickle Cell Disease
Your doctor may ask these questions to check for this symptom:
Reviewed By:
Unnati Patel, MD, MSc (Family Medicine)
Dr.Patel serves as Center Medical Director and a Primary Care Physician at Oak Street Health in Arizona. She graduated from the Zhejiang University School of Medicine prior to working in clinical research focused on preventive medicine at the University of Illinois and the University of Nevada. Dr. Patel earned her MSc in Global Health from Georgetown University, during which she worked with the WHO in Sierra Leone and Save the Children in Washington, D.C. She went on to complete her Family Medicine residency in Chicago at Norwegian American Hospital before completing a fellowship in Leadership in Value-based Care in conjunction with the Northwestern University Kellogg School of Management, where she earned her MBA. Dr. Patel’s interests include health tech and teaching medical students and she currently serves as Clinical Associate Professor at the University of Arizona School of Medicine.
Hidetaka Hamasaki, MD (Endocrinology)
Dr. Hamasaki graduated from the Hiroshima University School of Medicine and the Graduate School of Medicine, Jichi Medical University. He completed his residency at the Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine Hospital and the Department of Internal Medicine, Kohnodai Hospital, National Center for Global Health and Medicine. He has served in the National Center for Global Health and Medicine Hospital and Kohnodai Hospital and joined Hamasaki Clinic in April 2017. Dr. Hamasaki specializes in diabetes and treats a wide range of internal medicine and endocrine disorders.
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1