What are the symptoms related to hyperprolactinemia?

Related symptoms are: (1) Enlarged male breast tissue. (2) Headache. (3) Inappropriate milk production e.g. not pregnant or with recent childbirth, or as a male. (4) Difficulty getting pregnant

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Endocrinology

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Learn more about Hyperprolactinemia

Content updated on Jun 1, 2022

What is hyperprolactinemia?

Excessively high prolactin (hormone that releases milk) levels in the blood. Causes include medications and brain tumors.

Symptoms related to hyperprolactinemia

Enlarged male breast tissue
Headache
Inappropriate milk production e.g. not pregnant or with recent childbirth, or as a male
Difficulty getting pregnant

Questions your doctor may ask to check for hyperprolactinemia

Your doctor may ask these questions to diagnose hyperprolactinemia

Do you think your breasts are getting bigger?
Do you have headaches or does your head feel heavy?
Are you producing breast milk inappropriately (even though you have not been pregnant or given birth, or are a man)?
Are you having trouble getting pregnant despite trying for some time?

Treatment for hyperprolactinemia

Treatment focuses on decreasing prolactin levels back to normal. This is usually done with medications. In some cases, surgery or radiation may be required to remove a tumor.

View the symptoms of Hyperprolactinemia

Diseases related to Hyperprolactinemia

References

Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA; Endocrine Society. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Feb;96(2):273-88. doi: 10.1210/jc.2010-1692. PMID: 21296991.
https://academic.oup.com/jcem/article/96/2/273/2709487
Capozzi A, Scambia G, Pontecorvi A, Lello S. Hyperprolactinemia: pathophysiology and therapeutic approach. Gynecol Endocrinol. 2015 Jul;31(7):506-10. doi: 10.3109/09513590.2015.1017810. Epub 2015 Jul 6. PMID: 26291795.
https://www.tandfonline.com/doi/full/10.3109/09513590.2015.1017810
Vilar L, Vilar CF, Lyra R, Freitas MDC. Pitfalls in the Diagnostic Evaluation of Hyperprolactinemia. Neuroendocrinology. 2019;109(1):7-19. doi: 10.1159/000499694. Epub 2019 Mar 20. PMID: 30889571.
https://www.karger.com/Article/FullText/499694
Chahal J, Schlechte J. Hyperprolactinemia. Pituitary. 2008;11(2):141-6. doi: 10.1007/s11102-008-0107-5. PMID: 18404389.
https://link.springer.com/article/10.1007/s11102-008-0107-5
Matalliotakis M, Koliarakis I, Matalliotaki C, Trivli A, Hatzidaki E. Clinical manifestations, evaluation and management of hyperprolactinemia in adolescent and young girls: a brief review. Acta Biomed. 2019 Jan 23;90(1):149-157. doi: 10.23750/abm.v90i1.8142. PMID: 30889169; PMCID: PMC6502148.
https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/8142